Emerging perspectives on branched-chain amino acid metabolism during adipocyte differentiation.

Abstract:

PURPOSE OF REVIEW:Adipogenesis has been extensively studied in the context of carbohydrate and lipid metabolism. However, little information exists on the role of amino acid metabolism during adipocyte differentiation. Here, we review how branched-chain amino acid (BCAA) metabolism is modified during adipogenesis and, due to the limited information in the area, address questions that remain to be answered with further research. RECENT FINDINGS:BCAAs are rapidly consumed during adipocyte differentiation and are indispensable for this process. Furthermore, we describe how BCAA catabolic enzymes and the metabolic fate of BCAAs are modified during adipogenesis. SUMMARY:Obesity is a chronic disease characterized by increased adipose tissue due to either an increase in the size (hypertrophy) and/or number of adipocytes (hyperplasia). Hyperplasia is determined by the rate of adipogenesis. Therefore, understanding the mechanism that modulates adipogenesis in the context of amino acid metabolism will help to establish pharmacological and dietary interventions involving the type and amount of dietary protein for the treatment of obesity and its associated comorbidities.Video abstract http://links.lww.com/COCN/A11.

authors

Salinas-Rubio D,Tovar AR,Noriega LG

doi

10.1097/MCO.0000000000000429

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

49-57

issue

1

eissn

1363-1950

issn

1473-6519

journal_volume

21

pub_type

杂志文章,评审
  • Hormonal and nutritional drivers of intrauterine growth.

    abstract:PURPOSE OF REVIEW:Size at birth is critical in determining life expectancy with both small and large neonates at risk of shortened life spans. This review examines the hormonal and nutritional drivers of intrauterine growth with emphasis on the role of foetal hormones as nutritional signals in utero. RECENT FINDINGS:N...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32835e3643

    authors: Sferruzzi-Perri AN,Vaughan OR,Forhead AJ,Fowden AL

    更新日期:2013-05-01 00:00:00

  • New lipids in enteral feeding.

    abstract:PURPOSE OF REVIEW:Lipid sources for enteral nutrition continue to be an exciting area of investigation. It is timely to review recent developments which have largely contributed to thrust enteral feeding into a new era. RECENT FINDINGS:Although much more research needs to be done, there is a better understanding of th...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200403000-00003

    authors: Roy CC,Bouthillier L,Seidman E,Levy E

    更新日期:2004-03-01 00:00:00

  • Clogbusting: time for a concerted approach to catheter occlusions?

    abstract:PURPOSE OF REVIEW:Occlusions of central venous catheters in service are frequent, but the random nature of the problem has resulted in a piecemeal approach to solving it. The purpose of this review is to examine what is known from past and recent publications and to recommend strategies for future investigations. RECE...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000165006.39449.1f

    authors: Hardy G,Ball P

    更新日期:2005-05-01 00:00:00

  • Protein and physical activity in older persons.

    abstract:PURPOSE OF REVIEW:The aim of this study was to highlight recent evidence on protein requirement and physical activity recommendations in older adults and their interrelationship. RECENT FINDINGS:Higher protein intake in older adults is beneficial for better physical function, reduced fracture risk, healthy ageing and ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000685

    authors: Yeung SSY,Chan RSM,Woo J

    更新日期:2021-01-01 00:00:00

  • Fatty acids and endothelial cell function: regulation of adhesion molecule and redox enzyme expression.

    abstract::Different types of dietary fatty acids have distinct, and sometimes opposing, effects on endothelial cell function. Long-chain n-3 polyunsaturated fatty acids from fish oil (eicosapentaenoic-acid-20:5n-3 and docosahexaenoic-acid-22:6n-3) attenuate cytokine-induced adhesion molecule expression (mRNA and protein) while ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199903000-00003

    authors: Wahle KW,Rotondo D

    更新日期:1999-03-01 00:00:00

  • Nutritional assessment in the hospitalized patient.

    abstract:PURPOSE OF REVIEW:Malnutrition is highly prevalent in hospitalized patients. Despite this, it is not routinely assessed in most hospitals worldwide. One of the reasons that might explain this fact is that there is no gold-standard nutritional assessment tool, and much has been written advocating this or that technique....

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200309000-00006

    authors: Waitzberg DL,Correia MI

    更新日期:2003-09-01 00:00:00

  • Changes of protein kinetics in nephrotic patients.

    abstract::Nephrotic patients show various abnormalities in protein kinetics. Plasma albumin levels and the total plasma albumin pool are reduced. The rate of hepatic absolute and fractional albumin synthesis are increased. Transferrin synthesis is also increased. Fibrinogen levels are elevated in nephrotic syndrome because of a...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200201000-00010

    authors: Castellino P,Cataliotti A

    更新日期:2002-01-01 00:00:00

  • Nutrition support in patients with multiple organ failure.

    abstract::The problem with any attempt to feed patients in multiple organ failure is that, because of an ongoing inflammatory process, the conventional techniques of supplying energy and protein do not maintain lean tissue mass. In addition, the conventional markers of nutritional status, both anthropometric (body mass and comp...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-199803000-00012

    authors: Campbell IT

    更新日期:1998-03-01 00:00:00

  • The role of the peroxisome proliferator-activated receptor alpha pathway in pathological remodeling of the diabetic heart.

    abstract:PURPOSE OF REVIEW:Cardiovascular disease is exceptionally prevalent in patients with diabetes mellitus, which is an emerging pandemic. Unfortunately, the pathogenesis of diabetic myocardial disease is still poorly understood. RECENT FINDINGS:Evidence has emerged that perturbed cardiac energy metabolism (excessive depe...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000134371.70815.32

    authors: Finck BN

    更新日期:2004-07-01 00:00:00

  • Mammalian metabolism of erythritol: a predictive biomarker of metabolic dysfunction.

    abstract:PURPOSE OF REVIEW:To summarize recent advances in our understanding of mammalian erythritol metabolism and its use as a predictive biomarker of cardiometabolic disease risk. RECENT FINDINGS:Elevated serum erythritol predicts future central adiposity gain and type 2 diabetes mellitus in healthy adults. Erythritol is a ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000665

    authors: Ortiz SR,Field MS

    更新日期:2020-09-01 00:00:00

  • Diet of lactating women and allergic reactions in their infants.

    abstract:PURPOSE OF REVIEW:To evaluate whether the diet of lactating women modulates the development of allergic disease in their children. RECENT FINDINGS:Although maternal avoidance of common food protein allergens was previously recommended for lactating women with infants predisposed to allergic disease, recent expert revi...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000222113.46042.50

    authors: Palmer DJ,Makrides M

    更新日期:2006-05-01 00:00:00

  • Long-term effects of leucine supplementation on body composition.

    abstract:PURPOSE OF REVIEW:Leucine does not only serve as a substrate for protein synthesis but is also recognized as a potent signal nutrient that regulates protein metabolism. Accordingly, leucine supplementation has been suggested to develop muscle mass or prevent protein loss in several conditions characterized by muscle pr...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328336f6b8

    authors: Balage M,Dardevet D

    更新日期:2010-05-01 00:00:00

  • Assessing nutritional status in cancer: role of the Patient-Generated Subjective Global Assessment.

    abstract:PURPOSE OF REVIEW:The Scored Patient-Generated Subjective Global Assessment (PG-SGA) is used internationally as the reference method for proactive risk assessment (screening), assessment, monitoring and triaging for interventions in patients with cancer. This review aims to explain the rationale behind and data support...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000389

    authors: Jager-Wittenaar H,Ottery FD

    更新日期:2017-09-01 00:00:00

  • Meal patterns and childhood obesity.

    abstract:PURPOSE OF REVIEW:To summarize the literature concerning the relationship between meal patterns and childhood obesity. Literature searches of MEDLINE and the Cochrane Library were performed in October 2009 for studies published in the last 18-24 months. RECENT FINDINGS:Available data indicate that not only meal compos...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32833681a2

    authors: Patro B,Szajewska H

    更新日期:2010-05-01 00:00:00

  • Prevention of metabolic diseases: fruits (including fruit sugars) vs. vegetables.

    abstract:PURPOSE OF REVIEW:To discuss recent evidence from observational and intervention studies on the relationship between fruit and vegetable (F&V) consumption and metabolic disease. RECENT FINDINGS:Observational studies have consistently demonstrated a modest inverse association between the intake of fruit and leafy green...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000378

    authors: Kuzma JN,Schmidt KA,Kratz M

    更新日期:2017-07-01 00:00:00

  • Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.

    abstract:PURPOSE OF REVIEW:This review focuses upon the biology and metabolism of a trace component in foods called nicotinamide riboside. Nicotinamide riboside is a precursor of nicotinamide adenine dinucleotide (NAD), and is a source of Vitamin B3. Evidence indicates that nicotinamide riboside has unique properties as a Vitam...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32836510c0

    authors: Chi Y,Sauve AA

    更新日期:2013-11-01 00:00:00

  • Assessment of intramuscular triglycerides: contribution to metabolic abnormalities.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to highlight recent methodological advances that have helped us to understand the role of intramuscular triglycerides in human health as well as prevention and treatment of disease. In addition to both invasive (muscle biopsy) and noninvasive methods, techniques to assess...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000241664.38385.12

    authors: Dubé J,Goodpaster BH

    更新日期:2006-09-01 00:00:00

  • Role of the liver in the control of glucose-lipid utilization and body weight.

    abstract:PURPOSE OF REVIEW:This review depicts recent developments concerning the role of the liver in control of carbohydrate and lipid utilization from ingestion to storage; it covers the liver's influence on food intake, post-absorptive nutrient metabolism and body weight. The mechanisms involved have implications for the pa...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000078993.96795.16

    authors: Langhans W

    更新日期:2003-07-01 00:00:00

  • Vitamin D in the prevention and treatment of coronary heart disease.

    abstract:PURPOSE OF REVIEW:The pathogenesis of coronary heart disease is of multifactorial origin. Probably, not all risk factors are satisfactorily understood. This article outlines beneficial vitamin D effects on cardiac function and the vasculature. In addition, human data associating serum vitamin D metabolite levels or ora...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328312c33f

    authors: Zittermann A,Koerfer R

    更新日期:2008-11-01 00:00:00

  • Soft drinks and body weight development in childhood: is there a relationship?

    abstract:PURPOSE OF REVIEW:The high sugar content of regular soft drinks brought up discussions on their influence on energy balance and body weight especially in childhood and adolescence. This review examines the evidence for a causal relationship between soft drink consumption and excess weight gain in childhood and identifi...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32833189f6

    authors: Libuda L,Kersting M

    更新日期:2009-11-01 00:00:00

  • Nutrition in alcoholic steatohepatitis: more of the same or something new?

    abstract:PURPOSE OF REVIEW:To describe the evidences for and against the different nutritional and nonnutritional therapeutic approaches for severe alcoholic steatohepatitis, based on data from randomized controlled trials, in order to answer the question posed in the title: 'more of the same or something new?'. RECENT FINDING...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32830b5d1e

    authors: Cabré E

    更新日期:2008-09-01 00:00:00

  • Role of dietary carbohydrates and macronutrients in the pathogenesis of nonalcoholic fatty liver disease.

    abstract:PURPOSE OF REVIEW:The prevalence of nonalcoholic fatty liver disease is increasing worldwide and there is strong evidence that dietary factors play a role in its pathogenesis. The present review aims to provide a better understanding of how carbohydrates and other macronutrients may affect the disease. RECENT FINDINGS...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328302f3ec

    authors: Lê KA,Bortolotti M

    更新日期:2008-07-01 00:00:00

  • Ketone bodies as epigenetic modifiers.

    abstract:PURPOSE OF REVIEW:Ketone body metabolism is a dynamic and integrated metabolic node in human physiology, whose roles include but extend beyond alternative fuel provision during carbohydrate restriction. Here we discuss the most recent observations suggesting that ketosis coordinates cellular function via epigenomic reg...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000475

    authors: Ruan HB,Crawford PA

    更新日期:2018-07-01 00:00:00

  • Protein metabolic roles in treatment of obesity.

    abstract:PURPOSE OF REVIEW:To understand the potential benefits of increased dietary protein during weight loss and the importance of distribution of high-quality protein at each meal. RECENT FINDINGS:Popular weight loss diets emphasize use of protein as a substitute for carbohydrates or fat to reduce insulin and minimize hung...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32833a7737

    authors: Devkota S,Layman DK

    更新日期:2010-07-01 00:00:00

  • Modern treatment of short bowel syndrome.

    abstract:PURPOSE OF REVIEW:Recently, the US Food and Drug Administration and the European Medicines Agency approved the glucagon-like peptide 2 analogue, teduglutide, for the treatment of short bowel syndrome (SBS), and this review describes the physiological basis for its clinical use. RECENT FINDINGS:By affecting the intesti...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e328363bce4

    authors: Jeppesen PB

    更新日期:2013-09-01 00:00:00

  • Parenteral nutrition in critical illness: total, supplemental or never?

    abstract:PURPOSE OF REVIEW:The current review summarizes recent evolutions in knowledge and discusses the concept of whom and when parenteral nutrition should be considered in critically ill patients as a total form of nutrition, in a supplemental form, or never. RECENT FINDINGS:Recent developments in our understanding of the ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章

    doi:10.1097/MCO.0000000000000719

    authors: Ridley EJ

    更新日期:2020-12-10 00:00:00

  • Two elephants in the room: new hybrid nuclear magnetic resonance and mass spectrometry approaches for metabolomics.

    abstract:PURPOSE OF REVIEW:This review describes some of the advances made over the past year in NMR-based metabolomics for the elucidation of known and unknown compounds, including new ways of how to combine this information with high-resolution mass spectrometry. RECENT FINDINGS:A new method allows the back-calculation of ma...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0000000000000206

    authors: Bingol K,Brüschweiler R

    更新日期:2015-09-01 00:00:00

  • What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?

    abstract::Studies of many different rodent models of muscle wasting have indicated that accelerated proteolysis via the ubiquitin-proteasome pathway is the principal cause of muscle atrophy induced by fasting, cancer cachexia, metabolic acidosis, denervation, disuse, diabetes, sepsis, burns, hyperthyroidism and excess glucocort...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/00075197-200105000-00003

    authors: Jagoe RT,Goldberg AL

    更新日期:2001-05-01 00:00:00

  • Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes.

    abstract:PURPOSE OF REVIEW:Obesity is associated with low-grade chronic inflammation in adipose tissue. This review presents an update on human and rodent studies analyzing the nature of fat-infiltrating immune cells, the time course of adipose tissue infiltration and underlying mechanisms. RECENT FINDINGS:Intensive studies in...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/MCO.0b013e32833aab7f

    authors: Sell H,Eckel J

    更新日期:2010-07-01 00:00:00

  • Nutrients and dyspepsia: paradigms and reality.

    abstract:PURPOSE OF REVIEW:Dyspepsia is a common disorder that presents as persistent or recurrent abdominal pain or discomfort in the upper abdomen and originates from organic or functional causes. Heterogeneous disorders, physiopathological, psychosomatic, sociocultural, demographic and genetic components have a great impact ...

    journal_title:Current opinion in clinical nutrition and metabolic care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mco.0000179165.33323.18

    authors: de Baptista GA

    更新日期:2005-09-01 00:00:00