Abstract:
PURPOSE OF REVIEW:Adipogenesis has been extensively studied in the context of carbohydrate and lipid metabolism. However, little information exists on the role of amino acid metabolism during adipocyte differentiation. Here, we review how branched-chain amino acid (BCAA) metabolism is modified during adipogenesis and, due to the limited information in the area, address questions that remain to be answered with further research. RECENT FINDINGS:BCAAs are rapidly consumed during adipocyte differentiation and are indispensable for this process. Furthermore, we describe how BCAA catabolic enzymes and the metabolic fate of BCAAs are modified during adipogenesis. SUMMARY:Obesity is a chronic disease characterized by increased adipose tissue due to either an increase in the size (hypertrophy) and/or number of adipocytes (hyperplasia). Hyperplasia is determined by the rate of adipogenesis. Therefore, understanding the mechanism that modulates adipogenesis in the context of amino acid metabolism will help to establish pharmacological and dietary interventions involving the type and amount of dietary protein for the treatment of obesity and its associated comorbidities.Video abstract http://links.lww.com/COCN/A11.
journal_name
Curr Opin Clin Nutr Metab Carejournal_title
Current opinion in clinical nutrition and metabolic careauthors
Salinas-Rubio D,Tovar AR,Noriega LGdoi
10.1097/MCO.0000000000000429subject
Has Abstractpub_date
2018-01-01 00:00:00pages
49-57issue
1eissn
1363-1950issn
1473-6519journal_volume
21pub_type
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章
doi:10.1097/MCO.0000000000000685
更新日期:2021-01-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/00075197-200309000-00006
更新日期:2003-09-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:1998-03-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
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更新日期:2004-07-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2006-05-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e328336f6b8
更新日期:2010-05-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
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更新日期:2010-05-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0000000000000378
更新日期:2017-07-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
doi:10.1097/MCO.0b013e32836510c0
更新日期:2013-11-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2006-09-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
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更新日期:2008-11-01 00:00:00
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更新日期:2018-07-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2001-05-01 00:00:00
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journal_title:Current opinion in clinical nutrition and metabolic care
pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00
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更新日期:2005-09-01 00:00:00