Abstract:
:Angiogenesis is one of the pillars of neoplasia. Lymphangiogenesis in context of granulomas is not yet understood. This study aimed to evaluate the role of praziquantel (PZQ) and artemether (ART) as anti-angiogenic and anti-lymphangiogenic drugs in Schistosoma mansoni induced experimental hepatic model through immunohistochemical and serological studies, this can be used as a potential novel prophylactic approach in hepatic malignancy prevention and possible management. Forty female CD-1 Swiss albino mice were used divided into 4 groups (10 mice each); control healthy, control infected untreated, PZQ-treated and ART-treated. Angiogenic and lymphangiogenic effect of the drugs assessed pathologically through counting of the newly formed capillaries and lymphatics that immunohistochemically expressed by vascular Endothelial Growth Factor (VEGF), CD34 and D2-40 in liver sections using Cell Image Analyzer and serologically by evaluation of serum level of Tumor Necrosis Factor-Alpha (TNF-α). Our results showed significant decrease in serum TNF-α in ART-treated group compared to control infected and PZQ treated groups. ART exhibited significant anti-angiogenic role on granulomas illustrated by remarkable milder intensity and significantly lower expression values of VEGF and CD34 immunostaining compared to PZQ and non-treated groups. Also, ART treated group exhibited negative D2-40 expression in the granulomas in contrast to the other groups, supporting the potent ART' anti-lymphangiogenic role that exceeded PZQ. In conclusion, ART showed not only anti-angiogenic effect but also prominent anti-lymphangiogenic effect on hepatic S. mansoni granulomas compared to PZQ. Our study supports the potential use of ART as a potential novel prophylactic approach in hepatic malignancy prevention and possible management.
journal_name
Acta Parasitoljournal_title
Acta parasitologicaauthors
Abd El-Aal NF,Hamza RS,Magdy Mdoi
10.1515/ap-2017-0085subject
Has Abstractpub_date
2017-12-20 00:00:00pages
708-716issue
4eissn
1230-2821issn
1896-1851pii
/j/ap.2017.62.issue-4/ap-2017-0085/ap-2017-0085.xmjournal_volume
62pub_type
杂志文章abstract:INTRODUCTION:Alveolar echinococcosis (AE) is a zoonotic disease caused by the parasitism of Echinococcus multilocularis larvae in the intermediate host or the final host. This study aims to identify and analyze the B-cell and T-cell (Th1, Th2 and Th17) epitopes of E. multilocularis antigen Emy162. METHODS:(1) The seco...
journal_title:Acta parasitologica
pub_type: 杂志文章
doi:10.2478/s11686-020-00231-0
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To seek for the optimal immunization procedure of DNA vaccine pVAX1-pEtK2-IL-2 which was produced via cloning pEtK2 antigen gene of Eimeria tenella (E. tenella) and chicken IL-2 (chIL-2) gene into expression vector pVAX1. METHODS:The doses, routes, times of inoculation and ages of the first inoculation of chic...
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journal_title:Acta parasitologica
pub_type: 杂志文章
doi:10.2478/s11686-019-00041-z
更新日期:2019-12-01 00:00:00
abstract::Perumytilus purpuratus is an abundant bivalve located in the intertidal rocky zone of South America that has been considered as a key species of the ecosystem. There are few studies of the host-parasite relationship of this bivalve; thus, this research aims to analyse the spatial and temporal variation in the prevalen...
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更新日期:2013-06-01 00:00:00
abstract::Sera collected from healthy individuals from the general population in the Czech Republic during repeated cross-sectional surveys were analyzed. Samples collected in the same six districts in two time periods, 1978-1989 and 2001, were compared. The study subjects were divided into six age categories between 10 and 59 ...
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pub_type: 杂志文章
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abstract::Cystic hydatidosis is a re-emerging parasitic zoonosis with worldwide distribution. The current study was carried out to investigate the possible role of rats in the epidemiology of such disease in urban and suburban areas. For this purpose, a total of 50 feral Norway rats (Rattus norvegicus) were collected from urban...
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更新日期:2016-03-01 00:00:00
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更新日期:2020-09-01 00:00:00
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更新日期:2020-07-12 00:00:00
abstract::The Mascarene grass frog Ptychadena cf. mascareniensis is a species of frog with a vast area of distribution in Africa. A total of 300 frog specimens were collected from different localities at El-Giza province, Egypt; then dissected and examined for the presence of parasitic infection. Only eighty six (28.66%) specim...
journal_title:Acta parasitologica
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
abstract:PURPOSE:Dirofilariasis caused by the filarial nematode Dirofilaria repens is mainly a disease of dogs and other carnivores. Also, humans can be accidentally infected with this parasite. The infective third-stage filariform larvae are transmitted by various species of mosquitoes. Until this day, a total of 17 human case...
journal_title:Acta parasitologica
pub_type: 杂志文章
doi:10.2478/s11686-020-00170-w
更新日期:2020-06-01 00:00:00
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更新日期:2018-09-25 00:00:00
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abstract::Falcaustra tintlwini sp. nov. (Ascaridida, Kathlaniidae) from the large intestine of Batagur trivittata (Testudines, Geoemydidae) is described and illustrated. Falcaustra tintlwini represents the 20th Oriental species assigned to the genus and is distinguished from other Oriental species by the distribution pattern of...
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更新日期:2018-12-19 00:00:00
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pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-03-26 00:00:00
abstract::The aim of this retrospective, population-based study was to characterize demographically and clinically cystic-echinococcosis (CE) in southern Israel, between 2005 and 2012. Newly-diagnosed (nd-CE) and past-diagnosed (pd-CE, diagnosed before the study) cases were defined. Two populations live in southern-Israel, rece...
journal_title:Acta parasitologica
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更新日期:2016-01-01 00:00:00
abstract::Cosmocerca leytensis sp. nov. (Ascaridida, Cosmocercidae) from the large intestine of Cyrtodactylus gubaot (Squamata: Gekkonidae) collected on Leyte Island, Philippines is described and illustrated. Cosmocerca leytensis sp. nov. is the 30th species assigned to the genus, the 4th from the Oriental region, and the first...
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更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-07-20 00:00:00
abstract::A new species of Rhinonastes, hitherto monotypic, is described and illustrated from the nasal cavity of 'curimat', Prochilodus argenteus from São Francisco River, Brazil. Rhinonastes curimatae n. sp. presents a male copulatory organ with more than five rings while the type species of the genus is characterized by male...
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更新日期:2014-09-01 00:00:00
abstract::Ancylostoma ceylanicum belongs to a group of soil-transmitted helminths, which infect almost 576 mln people worldwide and are a major cause of anaemia and malnutrition. Upon contact with a permissive host, third-stage larvae (L3) residing in the environment become activated larvae (ssL3), a process associated with cha...
journal_title:Acta parasitologica
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更新日期:2013-03-01 00:00:00
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journal_title:Acta parasitologica
pub_type: 杂志文章
doi:10.2478/s11686-019-00139-4
更新日期:2020-03-01 00:00:00
abstract::A new feather mite species, Tyrannidectes pteroptochi sp. n. (Astigmata: Proctophyllodidae: Pterodectinae), is described from the Moustached Turca Pteroptochos megapodius Kittlitz, 1830 (Passeriformes: Rhinocryptidae) in Chile. This is the first record of mites of the genus Tyrannidectes Mironov 2008 from this family ...
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pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Acta parasitologica
pub_type: 杂志文章
doi:10.2478/s11686-014-0270-y
更新日期:2014-09-01 00:00:00
abstract::Naturally Leishmania infantum infected bitches were divided into oestrogenized (n = 11) and non-oestrogenized (n = 6) groups. Vaginal secretions were collected for polymerase chain reaction (PCR), and vulval, vaginal and uterine tissues were collected for the immunohistochemical (IHQ) identification of L. infantum. Pa...
journal_title:Acta parasitologica
pub_type: 杂志文章
doi:10.1515/ap-2017-0076
更新日期:2017-09-26 00:00:00
abstract::Larval trematodes infecting the snail Heleobia australis (Cochliopidae) from the Bahía Blanca estuary, Argentina were surveyed for two years. A total of 7,504 snail specimens was dissected and the larval stages of 15 different trematodes were recovered and examined morphologically. These larvae included four species t...
journal_title:Acta parasitologica
pub_type: 杂志文章
doi:10.2478/s11686-014-0209-3
更新日期:2014-03-01 00:00:00
abstract::An in vitro study has been carried out to monitor changes to the female reproductive system in adult triclabendazole (TCBZ)-resistant Fasciola hepatica following treatment with a commercial preparation of myrrh ("Mirazid"). Flukes were immersed for 6 h and 24 h in myrrh extract at a concentration of 200 µg/ml, then pr...
journal_title:Acta parasitologica
pub_type: 杂志文章
doi:10.1515/ap-2017-0041
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:Fish parasites can cause diseases in humans and lead to commercial losses in fisheries and aquaculture. The objectives of this study were to analyze E. ongus's parasite fauna regarding food safety and parasite transmission risk between Epinephelus species and test whether E.ongus populations can be distinguishe...
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pub_type: 杂志文章
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更新日期:2020-12-14 00:00:00
abstract:BACKGROUND:In spite of the global economic significance of sheep production, little is known about the prevalence of various Sarcocystis spp. infecting the domestic sheep (Ovis aries) in Egypt. MATERIALS AND METHODS:Muscle samples were collected from 175 sheep (> 2 years) slaughtered at El-Mahalla El-Kubra abattoir, G...
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pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00