Abstract:
BACKGROUND:Asymmetric degeneration of dopaminergic neurons, are characteristic for Parkinson's disease (PD). Despite the lateralized representation of language, the correlation of asymmetric degeneration of nigrostriatal networks in PD with language performance has scarcely been examined. OBJECTIVE/HYPOTHESIS:The laterality of dopamine depletion influences language deficits in PD and thus modulates the effects of subthalamic nucleus (STN) stimulation on language production. METHODS:The spontaneous language production of patients with predominant dopamine depletion of the left (PD-left) and right (PD-right) hemisphere was compared in four stimulation conditions. RESULTS:PD-right made comparatively more verb inflection errors than PD-left. Bilateral STN stimulation improves spontaneous language production only for PD-left. CONCLUSIONS:The laterality of dopamine depletion influences spontaneous language production and the effect of STN stimulation on linguistic functions. However, it is probably only one of the many variables influencing the effect of STN stimulation on language production.
journal_name
Brain Langjournal_title
Brain and languageauthors
Batens K,De Letter M,Raedt R,Duyck W,Vanhoutte S,Van Roost D,Santens Pdoi
10.1016/j.bandl.2015.06.002subject
Has Abstractpub_date
2015-08-01 00:00:00pages
76-84eissn
0093-934Xissn
1090-2155pii
S0093-934X(15)00122-4journal_volume
147pub_type
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