Burr-like, laser-made 3D microscaffolds for tissue spheroid encagement.

Abstract:

:The modeling, fabrication, cell loading, and mechanical and in vitro biological testing of biomimetic, interlockable, laser-made, concentric 3D scaffolds are presented. The scaffolds are made by multiphoton polymerization of an organic-inorganic zirconium silicate. Their mechanical properties are theoretically modeled using finite elements analysis and experimentally measured using a Microsquisher(®). They are subsequently loaded with preosteoblastic cells, which remain live after 24 and 72 h. The interlockable scaffolds have maintained their ability to fuse with tissue spheroids. This work represents a novel technological platform, enabling the rapid, laser-based, in situ 3D tissue biofabrication.

journal_name

Biointerphases

journal_title

Biointerphases

authors

Danilevicius P,Rezende RA,Pereira FD,Selimis A,Kasyanov V,Noritomi PY,da Silva JV,Chatzinikolaidou M,Farsari M,Mironov V

doi

10.1116/1.4922646

subject

Has Abstract

pub_date

2015-06-23 00:00:00

pages

021011

issue

2

eissn

1934-8630

issn

1559-4106

journal_volume

10

pub_type

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