Abstract:
:The modeling, fabrication, cell loading, and mechanical and in vitro biological testing of biomimetic, interlockable, laser-made, concentric 3D scaffolds are presented. The scaffolds are made by multiphoton polymerization of an organic-inorganic zirconium silicate. Their mechanical properties are theoretically modeled using finite elements analysis and experimentally measured using a Microsquisher(®). They are subsequently loaded with preosteoblastic cells, which remain live after 24 and 72 h. The interlockable scaffolds have maintained their ability to fuse with tissue spheroids. This work represents a novel technological platform, enabling the rapid, laser-based, in situ 3D tissue biofabrication.
journal_name
Biointerphasesjournal_title
Biointerphasesauthors
Danilevicius P,Rezende RA,Pereira FD,Selimis A,Kasyanov V,Noritomi PY,da Silva JV,Chatzinikolaidou M,Farsari M,Mironov Vdoi
10.1116/1.4922646subject
Has Abstractpub_date
2015-06-23 00:00:00pages
021011issue
2eissn
1934-8630issn
1559-4106journal_volume
10pub_type
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