A cholinergic antagonist blocks cold stress-induced alterations in rat adrenal tyrosine hydroxylase mRNA.

Abstract:

:The role of nicotinic cholinergic transmission in cold stress-induced alterations in rat adrenomedullary tyrosine hydroxylase (TH) mRNA was investigated by RNA dot-blot hybridization, using a cloned TH cDNA probe. Chlorisondamine, a ganglionic blocking agent, greatly attenuated the induction of TH mRNA levels caused by cold exposure, whereas carbachol and nicotine, cholinergic agonists, increased TH mRNA in control animals. These results suggest that cholinergic nicotinic receptors play a key role in the transsynaptic induction of adrenal TH gene expression.

journal_name

Brain Res

journal_title

Brain research

authors

Stachowiak M,Stricker EM,Zigmond MJ,Kaplan BB

doi

10.1016/0169-328x(88)90066-6

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

193-5

issue

2

eissn

0006-8993

issn

1872-6240

journal_volume

427

pub_type

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