Abstract:
:Genetic and environmental factors are both known to contribute to susceptibility to complex diseases. Therefore, the study of gene-environment interaction (G×E) has been a focus of research for several years. In this article, select examples of G×E from the literature are described to highlight different approaches and underlying principles related to the success of these studies. These examples can be broadly categorized as studies of single metabolism genes, genes in complex metabolism pathways, ranges of exposure levels, functional approaches and model systems, and pharmacogenomics. Some studies illustrated the success of studying exposure metabolism for which candidate genes can be identified. Moreover, some G×E successes depended on the availability of high-quality exposure assessment and longitudinal measures, study populations with a wide range of exposure levels, and the inclusion of ethnically and geographically diverse populations. In several examples, large population sizes were required to detect G×Es. Other examples illustrated the impact of accurately defining scale of the interactions (i.e., additive or multiplicative). Last, model systems and functional approaches provided insights into G×E in several examples. Future studies may benefit from these lessons learned.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Ritz BR,Chatterjee N,Garcia-Closas M,Gauderman WJ,Pierce BL,Kraft P,Tanner CM,Mechanic LE,McAllister Kdoi
10.1093/aje/kwx230subject
Has Abstractpub_date
2017-10-01 00:00:00pages
778-786issue
7eissn
0002-9262issn
1476-6256pii
3970812journal_volume
186pub_type
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