Lessons Learned From Past Gene-Environment Interaction Successes.

Abstract:

:Genetic and environmental factors are both known to contribute to susceptibility to complex diseases. Therefore, the study of gene-environment interaction (G×E) has been a focus of research for several years. In this article, select examples of G×E from the literature are described to highlight different approaches and underlying principles related to the success of these studies. These examples can be broadly categorized as studies of single metabolism genes, genes in complex metabolism pathways, ranges of exposure levels, functional approaches and model systems, and pharmacogenomics. Some studies illustrated the success of studying exposure metabolism for which candidate genes can be identified. Moreover, some G×E successes depended on the availability of high-quality exposure assessment and longitudinal measures, study populations with a wide range of exposure levels, and the inclusion of ethnically and geographically diverse populations. In several examples, large population sizes were required to detect G×Es. Other examples illustrated the impact of accurately defining scale of the interactions (i.e., additive or multiplicative). Last, model systems and functional approaches provided insights into G×E in several examples. Future studies may benefit from these lessons learned.

journal_name

Am J Epidemiol

authors

Ritz BR,Chatterjee N,Garcia-Closas M,Gauderman WJ,Pierce BL,Kraft P,Tanner CM,Mechanic LE,McAllister K

doi

10.1093/aje/kwx230

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

778-786

issue

7

eissn

0002-9262

issn

1476-6256

pii

3970812

journal_volume

186

pub_type

杂志文章,评审
  • A statewide outbreak of Escherichia coli O157:H7 infections in Washington State.

    abstract::In November 1986, a statewide outbreak of Escherichia coli O157:H7 infections in Washington State was identified after a physician in an eastern Washington community hospitalized three patients with hemorrhagic colitis which progressed to thrombotic thrombocytopenic purpura. Epidemiologic investigation identified 37 c...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115653

    authors: Ostroff SM,Griffin PM,Tauxe RV,Shipman LD,Greene KD,Wells JG,Lewis JH,Blake PA,Kobayashi JM

    更新日期:1990-08-01 00:00:00

  • Epidemiologic interactions, complexity, and the lonesome death of Max von Pettenkofer.

    abstract::In the mid-19th century, the German hygienist Max von Pettenkofer viewed cholera as resulting from the interaction between a postulated cholera germ and the characteristics of soils. In order to cause cholera, the cholera germ had to become a cholera miasma, but this transformation required prolonged contact of the ge...

    journal_title:American journal of epidemiology

    pub_type: 传,历史文章,杂志文章

    doi:10.1093/aje/kwm279

    authors: Morabia A

    更新日期:2007-12-01 00:00:00

  • Reliability of ophthalmic diagnoses in an epidemiologic survey.

    abstract::In the Nepal Blindness Survey, 39,887 people in 105 sites were examined by 10 ophthalmologists from Nepal and four other countries during 1981. Ophthalmic protocols were pretested on approximately 3000 subjects; however, interobserver variability was inevitable. To quantify the amount of variability and assess the rel...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113633

    authors: Brilliant LB,Lepkowski JM,Musch DC

    更新日期:1983-08-01 00:00:00

  • Epidemiologic programs for computers and calculators. Exact binomial confidence intervals for the relative risk in follow-up studies with sparsely stratified incidence density data.

    abstract::The authors present a computer program for hypothesis testing and calculation of exact binomial confidence intervals for the adjusted relative risk in follow-up studies involving multiple strata with incidence density (person-time) denominators and small or zero person-count numerators. The program is an extension to ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114535

    authors: Guess HA,Lydick EG,Small RD,Miller LP

    更新日期:1987-02-01 00:00:00

  • Risk.

    abstract::The epidemiologist primarily studies transitions between states of health and disease. The purpose of the present article is to define a foundational parameter for such studies, namely risk. We begin simply and build to the setting in which there is more than 1 event type (i.e., competing risks or competing events), a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwv001

    authors: Cole SR,Hudgens MG,Brookhart MA,Westreich D

    更新日期:2015-02-15 00:00:00

  • Factors associated with pilot fatality in work-related aircraft crashes, Alaska, 1990-1999.

    abstract::Work-related aircraft crashes are the leading cause of occupational fatality in Alaska, with civilian pilots having the highest fatality rate (410/100,000/year). To identify factors affecting survivability, the authors examined work-related aircraft crashes that occurred in Alaska in the 1990s (1990-1999), comparing c...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/154.11.1037

    authors: Bensyl DM,Moran K,Conway GA

    更新日期:2001-12-01 00:00:00

  • Early life financial adversity and respiratory function in midlife: a prospective birth cohort study.

    abstract::Data from the 1958 National Child Development Study (1958-2004) were used in a prospective study of the relation of financial adversity in childhood to lung function in midlife. It was hypothesized that such a relation would be found and would be mediated partly by early housing deprivation, partly by continuities in ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwr284

    authors: Bartley M,Kelly Y,Sacker A

    更新日期:2012-01-01 00:00:00

  • Condyloma and intraepithelial neoplasia of the uterine cervix: a case-control study.

    abstract::Cervical condyloma and cervical intraepithelial neoplasia are related to human papillomavirus infections, some of which may be involved in the etiology of cancer of the uterine cervix. This case-control study was designed to assess the relation of age at first sexual intercourse, number of sexual partners, and cigaret...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114973

    authors: Brisson J,Roy M,Fortier M,Bouchard C,Meisels A

    更新日期:1988-08-01 00:00:00

  • Prediction of subsequent ischemic heart disease using serial resting electrocardiograms.

    abstract::To test the hypothesis that subtle changes in the resting electrocardiogram can have predictive value for subsequent cardiovascular disease, the authors evaluated serial electrocardiograms from a cohort of initially healthy men and related these to later development of ischemic heart disease. The cohort of 1056 men or...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113739

    authors: Harlan WR,Cowie CC,Oberman A,Mitchell RE,MacIntyre NR

    更新日期:1984-02-01 00:00:00

  • Agreement rates between oral contraceptive users and prescribers in relation to drug use histories.

    abstract::A comparison between prescriber records and patient-reported oral contraceptive histories obtained during a case-control study of thromboembolism and oral contraceptive use served as the basis for evaluating the extent of agreement between these two sources of information. Agreement between oral contraceptive user and...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112529

    authors: Stolley PD,Tonascia JA,Sartwell PE,Tockman MS,Tonascia S,Rutledge A,Schinnar R

    更新日期:1978-03-01 00:00:00

  • Airborne particulate matter and mortality: timescale effects in four US cities.

    abstract::While time-series studies have consistently provided evidence for an effect of particulate air pollution on mortality, uncertainty remains as to the extent of the life-shortening implied by those associations. In this paper, the authors estimate the association between air pollution and mortality using different times...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwg087

    authors: Dominici F,McDermott A,Zeger SL,Samet JM

    更新日期:2003-06-15 00:00:00

  • Invited Commentary: The Enduring Role of "Place" in Health-A Historic Perspective.

    abstract::In public health, it has long been observed that "place"-specifically, where one lives-affects individual health, with the main research question distinguishing between the effects of "context" (defined as area characteristics) and "composition" (the characteristics of inhabitants) on health outcomes. There have been ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx085

    authors: Cozier YC

    更新日期:2017-06-01 00:00:00

  • Alcohol consumption and all-cause and cancer mortality among middle-aged Japanese men: seven-year follow-up of the JPHC study Cohort I. Japan Public Health Center.

    abstract::To examine the association between alcohol consumption and mortality in Japan, where mortality and lifestyle differ substantially from Western countries, a population-based prospective study was conducted in four public health center areas as part of the Japan Public Health Center-based prospective study on cancer and...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009946

    authors: Tsugane S,Fahey MT,Sasaki S,Baba S

    更新日期:1999-12-01 00:00:00

  • Association between prediagnostic biomarkers of inflammation and endothelial function and cancer risk: a nested case-control study.

    abstract::Experimental and prevalent case-control studies suggest an association between biomarkers of inflammation, endothelial function, and adiposity and cancer risk, but results from prospective studies have been limited. The authors' objective was to prospectively examine the relations between these biomarkers and cancer r...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/aje/kws359

    authors: Touvier M,Fezeu L,Ahluwalia N,Julia C,Charnaux N,Sutton A,Méjean C,Latino-Martel P,Hercberg S,Galan P,Czernichow S

    更新日期:2013-01-01 00:00:00

  • Preterm delivery rates in North Carolina: are they really declining among non-Hispanic African Americans?

    abstract::The preterm delivery rate in North Carolina is consistently higher than the national average. However, recent reports suggest that singleton preterm delivery rates for non-Hispanic Whites are increasing while those for non-Hispanic African Americans are decreasing. To study this pattern further, the authors examined d...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwh011

    authors: Vahratian A,Buekens P,Bennett TA,Meyer RE,Kogan MD,Yu SM

    更新日期:2004-01-01 00:00:00

  • Temporal change in the reproducibility of a self-administered food frequency questionnaire.

    abstract::The authors studied temporal change in the reproducibility of a self-administered food frequency questionnaire. During 1988-1994, 492 residents of a rural Japanese town completed five questionnaires including 27 food items, with intervals ranging from 2 weeks through 5.5 years. The reproducibility decreased steadily o...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117582

    authors: Tsubono Y,Nishino Y,Fukao A,Hisamichi S,Tsugane S

    更新日期:1995-12-01 00:00:00

  • Plurality of Birth and Infant Mortality Due to External Causes in the United States, 2000-2010.

    abstract::Risk of death during the first year of life due to external causes, such as unintentional injury and homicide, may be higher among twins and higher-order multiples than among singletons in the United States. We used national birth cohort linked birth-infant death data (2000-2010) to evaluate the risk of infant mortali...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kww119

    authors: Ahrens KA,Thoma ME,Rossen LM,Warner M,Simon AE

    更新日期:2017-03-01 00:00:00

  • Exogenous estrogens and endometrial cancer: a case-control study and assessment of potential biases.

    abstract::Eighty-eight cases with newly diagnosed carcinoma of the endometrium and 177 age-matched neighborhood controls were interviewed to test the hypothesis that exogenous estrogens lead to an increased risk of endometrial cancer. Forth-five per cent of the cases and 22% of the controls reported a history of estrogen use wh...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113215

    authors: Spengler RF,Clarke EA,Woolever CA,Newman AM,Osborn RW

    更新日期:1981-10-01 00:00:00

  • Nonspecific inflammatory bowel disease and smoking.

    abstract::The authors assessed the relation between cigarette smoking and nonspecific inflammatory bowel disease in a case-control study of 124 cases of ulcerative colitis, 109 cases of Crohn's disease, and 250 age- and sex-matched control subjects in hospital for acute nongastric or intestinal conditions unrelated to smoking. ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114550

    authors: Franceschi S,Panza E,La Vecchia C,Parazzini F,Decarli A,Bianchi Porro G

    更新日期:1987-03-01 00:00:00

  • Tracking of risk factors for coronary heart disease over a 14-year period: a comparison between lifestyle and biologic risk factors with data from the Amsterdam Growth and Health Study.

    abstract::Because the magnitude of tracking coefficients (i.e., stability coefficients and tracking for subjects at risk) greatly depends on the initial age of subjects, the number and spacing of longitudinal measurements, and the length of the total time period, it is difficult to compare tracking coefficients from different s...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009048

    authors: Twisk JW,Kemper HC,van Mechelen W,Post GB

    更新日期:1997-05-15 00:00:00

  • Leprosy case detection rates by age, sex, and polar type under leprosy control conditions.

    abstract::The knowledge of leprosy epidemiology is still extremely limited as to basic epidemiologic characteristics. Only the infectious agent and the reservoir of infection have been firmly established. It is all the more surprising that very few studies of analytical leprosy epidemiology are reported in the literature. In or...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114012

    authors: de Vries JL,Perry BH

    更新日期:1985-03-01 00:00:00

  • Factors associated with the distribution of fasting plasma glucose in an adult community.

    abstract::The fasting plasma glucose (FPG) was measured in 4170 nondiabetic adult residents of a suburban California community. At all ages the median FPG in men was higher (103-107 mg/dl) than the median FPG in women (96-104 mg/dl). FPG levels correlated weakly with obesity, and male-female differences persisted after adjustme...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113021

    authors: Barrett-Connor E

    更新日期:1980-10-01 00:00:00

  • Delayed application of condoms is a risk factor for human immunodeficiency virus infection among homosexual and bisexual men.

    abstract::The objective of this analysis was to identify risk factors for recent human immunodeficiency virus (HIV) infection among homosexual and bisexual men in Ontario, Canada, during 1998-2001. Participants were recruited through the provincial HIV diagnostic laboratory and through physicians and community organizations. HI...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwf195

    authors: Calzavara L,Burchell AN,Remis RS,Major C,Corey P,Myers T,Millson M,Wallace E

    更新日期:2003-02-01 00:00:00

  • Risk factors for secondary transmission in households after a common-source outbreak of Norwalk gastroenteritis.

    abstract::In November 1984, a foodborne outbreak of Norwalk gastroenteritis occurred in a K-12 public school in northern Vermont. The outbreak offered an opportunity to systematically study in detail secondary transmission rates in households. Eating salad at Tuesday's school-sponsored Thanksgiving Banquet was associated with i...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114756

    authors: Heun EM,Vogt RL,Hudson PJ,Parren S,Gary GW

    更新日期:1987-12-01 00:00:00

  • Exposure opportunity in case-control studies.

    abstract::Efficient control of confounding is well recognized as a legitimate motive for restriction, matching, and conditional analysis in case-control studies. Some investigators, however, have advocated use of the same techniques for another purpose: to achieve a balance of "opportunity" or "potential" for past exposure betw...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114244

    authors: Poole C

    更新日期:1986-02-01 00:00:00

  • Do common mental disorders increase cigarette smoking? Results from five waves of a population-based panel cohort study.

    abstract::A prospective panel cohort design was used to investigate whether mental disorders common in the general population increase the likelihood of increased cigarette smoking at 12 months follow-up. By 1995, the last year for which data were available, a random sample of 12,057 persons aged 16-75 years residing in private...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/152.7.651

    authors: Ismail K,Sloggett A,De Stavola B

    更新日期:2000-10-01 00:00:00

  • Case-control study of use of nonsteroidal antiinflammatory drugs and glioblastoma multiforme.

    abstract::Evidence from epidemiologic and experimental studies suggests that use of nonsteroidal antiinflammatory drugs (NSAIDs) reduces risk of colon and breast cancer. The association between use of aspirin and other NSAIDs and risk of adult glioblastoma multiforme (GBM) was evaluated among 236 incident GBM cases and 401 popu...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwh153

    authors: Sivak-Sears NR,Schwartzbaum JA,Miike R,Moghadassi M,Wrensch M

    更新日期:2004-06-15 00:00:00

  • Guillain-Barré syndrome and its relationship to swine influenza vaccination in Michigan, 1976-1977.

    abstract::Active surveillance to detect all patients with Guillain-Barré syndrome who had had onset of illness from July 1, 1976 through April 30, 1977 was undertaken in Michigan after indications that the syndrome might be associated with the National Influenza Immunization Program of 1976-1977. Hospital record room librarians...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113810

    authors: Breman JG,Hayner NS

    更新日期:1984-06-01 00:00:00

  • Simple Estimation of Patient-Oriented Effects From Randomized Trials: An Open and Shut CACE.

    abstract::In randomized controlled trials, the intention-to-treat estimator provides an unbiased estimate of the causal effect of treatment assignment on the outcome. However, patients often want to know what the effect would be if they were to take the treatment as prescribed (the patient-oriented effect), and several research...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/aje/kwv065

    authors: Steele RJ,Shrier I,Kaufman JS,Platt RW

    更新日期:2015-09-15 00:00:00

  • Antioxidant vitamin intake and mortality: the Leisure World Cohort Study.

    abstract::To assess the relationship between antioxidant vitamin intake and all-cause mortality in older adults, we examined these associations using data from the Leisure World Cohort Study, a prospective study of residents of the Leisure World retirement community in Laguna Hills, California. In the early 1980s, participants ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwu294

    authors: Paganini-Hill A,Kawas CH,Corrada MM

    更新日期:2015-01-15 00:00:00