Alpha thalassemia among sickle cell anaemia patients in Kampala, Uganda.

Abstract:

BACKGROUND:Sickle cell anaemia is prevalent in sub Saharan Africa. While α+-thalassaemia is known to modulate sickle cell anaemia, its magnitude and significance in Uganda have hitherto not been described. OBJECTIVES:To determine the prevalence of α+thalassaemia among sickle cell anaemia patients in Mulago Hospital and to describe the clinical and laboratory findings in these patients. METHODS:A cross sectional study was carried out on patients with sickle cell anaemia in Kampala. Dried blood spots were used to analyze for the deletional α+ thalassaemia using multiplex polymerase chain reaction. RESULTS:Of the 142 patients with sickle cell anaemia, 110 (77.5%) had the αα+thalassaemia deletion. The gene frequency of (-α) was 0.425. Ninety one percent (100/110) of those with α+thalassaemia were heterozygous (αα/α-). Amongst the patients older than 60 months, 15 (83.3%) of those without αα+thalassaemia had significant hepatomegaly of greater than 4 cm compared to 36 (45.6%) of those with α+thalassaemia (p=0.003). CONCLUSION:The gene frequency of (-α) of 0.425 noted in this study is higher than that reported from many places in Africa. Concurrent alpha thalassemia might be a protective trait against significant hepatomegaly in sickle cell anaemia patients more than 60 months of age at Mulago hospital.

journal_name

Afr Health Sci

journal_title

African health sciences

authors

Lubega I,Ndugwa CM,Mworozi EA,Tumwine JK

doi

10.4314/ahs.v15i2.48

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

682-9

issue

2

eissn

1680-6905

issn

1729-0503

pii

jAFHS.v15.i2.pg682

journal_volume

15

pub_type

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