Abstract:
: Agaricus is known to have immunostimulatory and anti-tumor effects. However, the antiviral effects of Agaricus have not yet been examined. In the present study, the antiviral effects of an extract of Agaricus brasiliensis KA21 (AE) on the H1N1 influenza virus (PR8 strain) were investigated. The anti-influenza virus effects of AE were examined by using the plaque formation inhibition test. AE inhibited the plaque formation of PR8 in a dose-dependent manner: 98 and 50% (IC50) inhibition at 2.5 and 0.99 mg/mL, respectively. To elucidate the mechanisms of AE, the direct actions and adsorption and invasion inhibition of AE were examined, and were found to have no inhibitory effect on PR8 infection. Thus, in vitro antiviral effects may somehow inhibit PR8 after the viral invasion of cells. These results demonstrated that it is expected that AE can effectively prevent the spread of the influenza virus.
journal_name
Biocontrol Scijournal_title
Biocontrol scienceauthors
Eguchi N,Fujino K,Thanasut K,Taharaguchi M,Motoi M,Motoi A,Oonaka K,Taharaguchi Sdoi
10.4265/bio.22.171subject
Has Abstractpub_date
2017-01-01 00:00:00pages
171-174issue
3eissn
1342-4815issn
1884-0205journal_volume
22pub_type
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