Identification of Biomarkers for Predicting Lymph Node Metastasis of Stomach Cancer Using Clinical DNA Methylation Data.

abstract：Background:Preeclamptic pregnancies often present an intensified inflammatory state associated with the nuclear activity of NFκB. NEMO is an essential regulator of nuclear factor kappa B (NFκB) in cytoplasmic and nuclear cellular compartments. The aim of the present study is to examine the level and localization of the...

journal_title：Disease markers

authors： Sakowicz A,Lisowska M,Biesiada L,Płuciennik E,Gach A,Rybak-Krzyszkowska M,Huras H,Sakowicz B,Romanowicz H,Piastowska-Ciesielska AW,Grzesiak M,Pietrucha T

更新日期：2019-01-02 00:00:00

abstract：AIMS:To study the changes of the metabolic profile during the pathogenesis in monocrotaline (MCT) induced pulmonary arterial hypertension (PAH). METHODS:Forty male Sprague-Dawley (SD) rats were randomly divided into 5 groups (n = 8, each). PAH rats were induced by a single dose intraperitoneal injection of 60 mg/kg MC...

journal_title：Disease markers

authors： Lin T,Gu J,Huang C,Zheng S,Lin X,Xie L,Lin D

更新日期：2016-01-01 00:00:00

abstract：:Cardiovascular diseases are the main causes of mortality. Sudden cardiac death may also appear in athletes, due to underlying congenital or inherited cardiac abnormalities. The electrocardiogram is used in clinical practice and clinical trials, as a valid, reliable, accessible, inexpensive method. The aim of the prese...

journal_title：Disease markers

authors： Mozos I,Caraba A

更新日期：2015-01-01 00:00:00

abstract：:PIZ allele frequencies were defined by PCR amplification and hybridization using a PIZ SSO (sequence specific oligonucleotide) probe. The groups studied included 64 normal controls, 104 subjects with rheumatoid arthritis (RA) without any extra-articular features, 29 of whom had severe arthritis and 31 of whom had mild...

journal_title：Disease markers

authors： Steers G,McMahon MJ,Grennan DM,Hillarby MC

更新日期：1992-05-01 00:00:00

abstract：:Cytoplasmic islet cell antibodies (ICA) were determined in a group of non-diabetic Caucasian schoolchildren (n = 4208). The prevalence rate for ICA positivity was 1.05 per cent (95 per cent confidence interval: 0.8-1.4 per cent). Analysis of HLA risk factors revealed that HLA-DRB1*03 (p less than 0.01), HLA-DRB1*04 (p...

journal_title：Disease markers

authors： Boehm BO,Seissler J,Glück M,Manfras BJ,Thomas H,Schmidt K,Rudert WA,Usadel KH,Trucco M,Scherbaum WA

更新日期：1991-09-01 00:00:00

abstract：Backgrounds:Both pretreatment serum CRP (C-reactive protein) level and ALB (albumin) level have been found to be predictive of survival for multiple malignancies including sarcoma. Since both of the GPS (Glasgow prognostic score) and CAR (C-reactive protein to albumin ratio) are based on the combination of CRP and ALB,...

journal_title：Disease markers

authors： Fang E,Wang X,Feng J,Zhao X

更新日期：2020-01-07 00:00:00

abstract：Background:Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone. Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepreg...

journal_title：Disease markers

authors： Liu L,Hu J,Yang L,Wang N,Liu Y,Wei X,Gao M,Wang Y,Ma Y,Wen D

更新日期：2020-04-14 00:00:00

abstract：PURPOSE:The clinical behavior of unicystic ameloblastoma varies according to its subtype. The assessment of its proliferative capacity, neovascularization, and invasiveness using relevant immunomarkers may aid in appropriate surgical therapeutic protocol. METHODS:18 cases of clinically and histologically confirmed uni...

journal_title：Disease markers

authors： Sah P,Menon A,Kamath A,Chandrashekar C,Carnelio S,Radhakrishnan R

更新日期：2013-01-01 00:00:00

abstract：UNLABELLED:The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. METHODS:Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels,...

journal_title：Disease markers

authors： Sahin A,Calhan T,Cengiz M,Kahraman R,Aydin K,Ozdil K,Korachi M,Sokmen HM

更新日期：2014-01-01 00:00:00

abstract：AIM:In this study, we aimed to investigate the relationship between the histological fibrosis stage of nonalcoholic fatty liver disease (NAFLD) and serum connective tissue growth factor (CTGF) to determine the usefulness of this relationship in clinical practice. METHODS:Serum samples were collected from 51 patients w...

journal_title：Disease markers

authors： Colak Y,Senates E,Coskunpinar E,Oltulu YM,Zemheri E,Ozturk O,Doganay L,Mesci B,Yilmaz Y,Enc FY,Kiziltas S,Ulasoglu C,Tuncer I

更新日期：2012-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2016/4703854.]. ...

journal_title：Disease markers

authors： Mutuiri SPM,Kutima HL,Mwapagha LM,Munyao JK,Kebira AN,Wanjiru I,Khamadi SA

更新日期：2017-01-01 00:00:00

abstract：Objectives:Periodontal disease is prevalent and has an inflammation associated with not only oral but also systemic pathologies. The diagnosis by biomarkers is required for clinical practice on periodontal disease. The lactoferrin and α1-antitrypsin were both inflammation-related molecules. The present study investigat...

journal_title：Disease markers

authors： Koshi R,Kotani K,Ohtsu M,Yoshinuma N,Sugano N

更新日期：2018-11-07 00:00:00

abstract：OBJECTIVE:The present study investigated the prevalence of the IL-28B polymorphisms rs12979860 and rs8099917 in chronic hepatitis B patients from a case study in Eastern Amazonia. METHODS:In total, 65 chronically infected HBV patients and 97 healthy subjects who were anti-HBc and anti-HBs positive (control group) were...

journal_title：Disease markers

authors： Conde SR,Rocha LL,Ferreira VM,Monteiro JC,Filgueiras NK,Lins PA,dos Santos BT,Freitas FB,Graça Eda S,Demachki S,de Araújo MT,Ishak R,Vallinoto AC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Tissue Polypeptide Specific antigen has recently been proposed as diagnostic marker of apoptosis in NonAlcoholic SteatoHepatitis. The aim of this study was to validate in patients suffering from NonAlcoholic SteatoHepatitis the clinical utility of this marker after different programs of weight reduction. ME...

journal_title：Disease markers

authors： Tarantino G,Mazzarella C,Tarantino M,Di Minno MN,Conca P

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:We investigated the relationship between NT-pro-BNP, glomerular filtration rate (GFR), and all-cause mortality rates in a cohort of older people discharged from an internal medicine unit after admission for dyspnoea. PATIENTS AND METHODS:NT-pro-BNP was evaluated in serum samples of 134 patients aged 80 ± 6 ...

journal_title：Disease markers

authors： Fabbian F,De Giorgi A,Pala M,Volpato S,Portaluppi F,Zuliani G,Manfredini R

更新日期：2013-01-01 00:00:00

abstract：Background:We have previously shown that the deficiency of the gut enzyme intestinal alkaline phosphatase (IAP) is associated with type 2 diabetes mellitus (T2DM) in humans, and mice deficient in IAP develop the metabolic syndrome, a precipitant of T2DM and ischemic heart disease (IHD). We hypothesized that IAP deficie...

journal_title：Disease markers

authors： Malo J,Alam MJ,Shahnaz M,Kaliannan K,Chandra G,Aziz T,Sarker T,Bala M,Paul R,Saha CK,Karmakar PK,Malo MS

更新日期：2019-12-13 00:00:00

abstract：Background:Syndecan-1 (SDC1/CD138) is a key cell surface adhesion molecule essential for maintaining cell morphology and the interactions with the surrounding microenvironment. SDC1 tumor immunoexpression may be increased or decreased in epithelial malignant neoplasms compared to that in adjacent non-neoplastic tissue,...

journal_title：Disease markers

authors： Li K,Li L,Wu X,Yu J,Ma H,Zhang R,Li Y,Wang W

更新日期：2019-04-30 00:00:00

abstract：:The surface and cytoplasmic expression of CD1a molecules was analysed by indirect immunofluorescence (IIF) and dot blot assay (DBA) in a panel of 40 acute and chronic leukaemias. Thirty-two per cent of the samples were positive by IIF but, surprisingly, 72 per cent of the patients were positive by DBA, suggesting the ...

journal_title：Disease markers

authors： Salamone MC,Roisman FR,Morelli AE,Noli MI,Fainboim L

更新日期：1990-09-01 00:00:00

abstract：:PD1/PDL1 inhibitors have been adopted for the treatment of advanced non-small-cell lung cancer, and PDL1 expression has been investigated as a predictive biomarker for PD1/PDL1 inhibitor therapy. However, PDL1 lacks diagnostic accuracy in differentiating patients who are likely or unlikely to benefit. So, it is urgent...

journal_title：Disease markers

authors： Wu Y,Lin L,Liu X

更新日期：2020-06-09 00:00:00

abstract：BACKGROUND:Tumor cells show alterations in their glycosylation patterns when compared to normal cells. Lectins can be used to evaluate these glycocode changes. Chemiluminescence assay is an effective technique for quantitative analysis of proteins, nucleic acids, and carbohydrates due to its high sensitivity, specifici...

journal_title：Disease markers

authors： Lima LR,Bezerra MF,Almeida SM,Silva LP,Beltrão EI,Carvalho Júnior LB

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:During progression of gastric cancer (GC), degradation of the extracellular matrix is mediated by the matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs): changes in the expression of these have been related to unfavorable prognosis in GC. OBJECTIVE:To analyze the expression of certain MMPs a...

journal_title：Disease markers

authors： de la Peña S,Sampieri CL,Ochoa-Lara M,León-Córdoba K,Remes-Troche JM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To investigate the expression of estrogen (ER), progesterone receptors (PR), nuclear factor- κ B (NF- κ B), and tumor necrosis factor- α (TNF- α ) in human breast cancer (BC), and the correlation of these four parameters with clinicopathological features of BC. METHODS AND RESULTS:We performed an immunohist...

journal_title：Disease markers

authors： Zhou XL,Fan W,Yang G,Yu MX

更新日期：2014-01-01 00:00:00

abstract：Background:The systemic immune-inflammation index (SII), based on peripheral lymphocytes, neutrophils, and platelet count, has been used as a prognostic marker for several tumors. However, use of the SII has not been reported for gastric cancer. Methods:We evaluated the prognostic value of the SII in primary and valid...

journal_title：Disease markers

authors： Shi H,Jiang Y,Cao H,Zhu H,Chen B,Ji W

更新日期：2018-12-02 00:00:00

abstract：Objectives:To explore the impact of volume change in the fractionated tracking of stereotactic radiotherapy on the results of synchronous, respiratory tracking algorithm using CyberKnife. Methods:A total of 38 lung tumor patients receiving stereotactic radiotherapy at our center from March 2018 to October 2019 were co...

journal_title：Disease markers

authors： Li GQ,Wang Y,Qiu MJ,Yang J,Peng ZJ,Zhang S,Fang X,Yang SL

更新日期：2020-01-11 00:00:00

abstract：BACKGROUND:The associations between the Fractalkine receptor (CX3CR1) gene T280M (rs3732378) and V249I (rs3732379) polymorphisms and atherosclerosis (AS) risk are conflicting. The aim of this meta-analysis was undertaken to assess their associations. METHODS:PubMed, Embase, Web of Science, Medline, Cochrane database, ...

journal_title：Disease markers

authors： Wu J,Yin RX,Lin QZ,Guo T,Shi GY,Sun JQ,Shen SW,Li Q

更新日期：2014-01-01 00:00:00

abstract：:Cyclin-dependent kinase regulatory subunit 2 (CKS2) is a member of the cell cycle-dependent protein kinase subunit family, which is implicated as an oncogene in various malignancies. However, the clinical significance, oncogenic functions, and related mechanisms of CKS2 in hepatocellular carcinoma (HCC) remain largely...

journal_title：Disease markers

authors： Zhang J,Song Q,Liu J,Lu L,Xu Y,Zheng W

更新日期：2019-10-22 00:00:00

abstract：:In view of the potential uses of cell surface tumour associated antigens in novel anticancer treatment, a study was designed to investigate whether the biological response modifiers interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) could effect the expression of an epitope on the tumour associa...

journal_title：Disease markers

authors： Clark S,McGuckin MA,Hurst T,Ward BG

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD. METHODS:We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patien...

journal_title：Disease markers

authors： Szeto CC,Ching-Ha KB,Ka-Bik L,Mac-Moune LF,Cheung-Lung CP,Gang W,Kai-Ming C,Kam-Tao LP

更新日期：2012-01-01 00:00:00

abstract：Objectives:We investigated the influence of spinal cord stimulation (SCS) on IFN-γ, IL-1β, IL-6, TNF-α, IL-10, and TGF-β serum levels in failed back surgery syndrome (FBSS) patients. The study will try to give new insights into the mechanism of SCS action and the role of IFN-γ and other cytokines in neuropathic pain (N...

journal_title：Disease markers

authors： Kamieniak P,Bielewicz J,Grochowski C,Litak J,Bojarska-Junak A,Daniluk B,Trojanowski T

更新日期：2019-01-14 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that accounts for nearly 70% of the more than 46 million dementia cases estimated worldwide. Although there is no cure for AD, early diagnosis and an accurate characterization of the disease progression can improve the quality of life of AD patients and their ca...

journal_title：Disease markers

authors： Cassani R,Estarellas M,San-Martin R,Fraga FJ,Falk TH

更新日期：2018-10-04 00:00:00