HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation.

Abstract:

:HIV infection and illicit drugs are known to induce oxidative stress and linked with severity of viral replication, disease progression, impaired cell cycle regulation and neurodegeneration. Studies have shown that morphine accelerates HIV infection and disease progression mediated by Reactive oxygen species (ROS). Oxidative stress impact redox balance and ROS production affect cell cycle regulation. However, the role of morphine in HIV associated acceleration of oxidative stress and its link to cell cycle regulation and neurodegeneration has not been elucidated. The aim of present study is to elucidate the mechanism of oxidative stress induced glutathione synthases (GSS), super oxide dismutase (SOD), and glutathione peroxidase (GPx) impact cell cycle regulated protein cyclin-dependent kinase 1, cell division cycle 2 (CDK-1/CDC-2), cyclin B, and cell division cycle 25C (CDC-25C) influencing neuronal dysfunction by morphine co-morbidity with HIV-1 gp120. It was observed that redox imbalance inhibited the GSS, GPx and increased SOD which, subsequently inhibited CDK-1/CDC-2 whereas cyclin B and CDC-25C significantly up regulated in HIV-1 gp120 with morphine compared to either HIV-1 gp120 or morphine treated alone in human microglial cell line. These results suggest that HIV positive morphine users have increased levels of oxidative stress and effect of cell cycle machinery, which may cause the HIV infection and disease progression.

journal_name

Front Microbiol

authors

Samikkannu T,Ranjith D,Rao KV,Atluri VS,Pimentel E,El-Hage N,Nair MP

doi

10.3389/fmicb.2015.00614

subject

Has Abstract

pub_date

2015-06-23 00:00:00

pages

614

issn

1664-302X

journal_volume

6

pub_type

杂志文章
  • Distinctive Nuclear Localization Signals in the Oomycete Phytophthora sojae.

    abstract::To date, nuclear localization signals (NLSs) that target proteins to nuclei in oomycetes have not been defined, but have been assumed to be the same as in higher eukaryotes. Here, we use the soybean pathogen Phytophthora sojae as a model to investigate these sequences in oomycetes. By establishing a reliable in vivo N...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00010

    authors: Fang Y,Jang HS,Watson GW,Wellappili DP,Tyler BM

    更新日期:2017-02-02 00:00:00

  • Prediction of T4SS Effector Proteins for Anaplasma phagocytophilum Using OPT4e, A New Software Tool.

    abstract::Type IV secretion systems (T4SS) are used by a number of bacterial pathogens to attack the host cell. The complex protein structure of the T4SS is used to directly translocate effector proteins into host cells, often causing fatal diseases in humans and animals. Identification of effector proteins is the first step in...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01391

    authors: Esna Ashari Z,Brayton KA,Broschat SL

    更新日期:2019-06-21 00:00:00

  • Soil Bacterial Function Associated With Stylo (Legume) and Bahiagrass (Grass) Is Affected More Strongly by Soil Chemical Property Than by Bacterial Community Composition.

    abstract::Soil microbes are driver of nutrient cycling, with microbial function affected by community composition and soil chemical property. Legume and grass are ubiquitous in many ecosystems, however, their differential effects on microbial function are less understood. Here we constructed compartmented rhizobox planted with ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00798

    authors: Zhou Y,Qin Y,Liu X,Feng Z,Zhu H,Yao Q

    更新日期:2019-04-12 00:00:00

  • Two Major Clades of Bradyrhizobia Dominate Symbiotic Interactions with Pigeonpea in Fields of Côte d'Ivoire.

    abstract::In smallholder farms of Côte d'Ivoire, particularly in the northeast of the country, Cajanus cajan (pigeonpea) has become an important crop because of its multiple beneficial facets. Pigeonpea seeds provide food to make ends meet, are sold on local markets, and aerial parts serve as forage for animals. Since it fixes ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01793

    authors: Fossou RK,Ziegler D,Zézé A,Barja F,Perret X

    更新日期:2016-11-11 00:00:00

  • Multi-Method Characterization of the Human Circulating Microbiome.

    abstract::The term microbiome describes the genetic material encoding the various microbial populations that inhabit our body. Whilst colonization of various body niches (e.g., the gut) by dynamic communities of microorganisms is now universally accepted, the existence of microbial populations in other "classically sterile" loc...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.03266

    authors: Whittle E,Leonard MO,Harrison R,Gant TW,Tonge DP

    更新日期:2019-01-17 00:00:00

  • The Association between Invasive Group A Streptococcal Diseases and Viral Respiratory Tract Infections.

    abstract::Viral infections of the upper respiratory tract are associated with a variety of invasive diseases caused by Streptococcus pyogenes, the group A streptococcus, including pneumonia, necrotizing fasciitis, toxic shock syndrome, and bacteremia. While these polymicrobial infections, or superinfections, are complex, progre...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2016.00342

    authors: Herrera AL,Huber VC,Chaussee MS

    更新日期:2016-03-21 00:00:00

  • Two Type VI Secretion Systems of Enterobacter cloacae Are Required for Bacterial Competition, Cell Adherence, and Intestinal Colonization.

    abstract::Enterobacter cloacae has emerged as an opportunistic pathogen in healthcare-associated infections. Analysis of the genomic sequences of several E. cloacae strains revealed the presence of genes that code for expression of at least one type VI secretion system (T6SS). Here, we report that E. cloacae strain ATCC 13047 c...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.560488

    authors: Soria-Bustos J,Ares MA,Gómez-Aldapa CA,González-Y-Merchand JA,Girón JA,De la Cruz MA

    更新日期:2020-09-24 00:00:00

  • CCp5A Protein from Toxoplasma gondii as a Serological Marker of Oocyst-driven Infections in Humans and Domestic Animals.

    abstract::Considering that the current immunoassays are not able to distinguish the infective forms that cause Toxoplasma gondii infection, the present study was carried out to evaluate the reactivity of two recombinant proteins (CCp5A and OWP1) from oocyst/sporozoite, in order to differentiate infections occurring by ingestion...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.01305

    authors: Santana SS,Gebrim LC,Carvalho FR,Barros HS,Barros PC,Pajuaba AC,Messina V,Possenti A,Cherchi S,Reiche EM,Navarro IT,Garcia JL,Pozio E,Mineo TW,Spano F,Mineo JR

    更新日期:2015-11-24 00:00:00

  • Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles.

    abstract::Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis. To date, these transcriptional responses have been shown to be dependent on the presence of the azoles and/or depletion of ergosterol. Usi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.00009

    authors: Hu C,Zhou M,Wang W,Sun X,Yarden O,Li S

    更新日期:2018-01-17 00:00:00

  • The Rho Termination Factor of Clostridium botulinum Contains a Prion-Like Domain with a Highly Amyloidogenic Core.

    abstract::Prion-like proteins can switch between a soluble intrinsically disordered conformation and a highly ordered amyloid assembly. This conformational promiscuity is encoded in specific sequence regions, known as prion domains (PrDs). Prions are best known as the causative factors of neurological diseases in mammals. Howev...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.01516

    authors: Pallarès I,Iglesias V,Ventura S

    更新日期:2016-01-07 00:00:00

  • Plasmids of psychrophilic and psychrotolerant bacteria and their role in adaptation to cold environments.

    abstract::Extremely cold environments are a challenge for all organisms. They are mostly inhabited by psychrophilic and psychrotolerant bacteria, which employ various strategies to cope with the cold. Such harsh environments are often highly vulnerable to the influence of external factors and may undergo frequent dynamic change...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2014.00596

    authors: Dziewit L,Bartosik D

    更新日期:2014-11-06 00:00:00

  • The N-Terminus of Human Lactoferrin Displays Anti-biofilm Activity on Candida parapsilosis in Lumen Catheters.

    abstract::Candida parapsilosis is a major cause of hospital-acquired infection, often related to parenteral nutrition administered via catheters and hand colonization of health care workers, and its peculiar biofilm formation ability on plastic surfaces. The mortality rate of 30% points to the pressing need for new antifungal d...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02218

    authors: Fais R,Di Luca M,Rizzato C,Morici P,Bottai D,Tavanti A,Lupetti A

    更新日期:2017-11-13 00:00:00

  • The comER Gene Plays an Important Role in Biofilm Formation and Sporulation in both Bacillus subtilis and Bacillus cereus.

    abstract::Bacteria adopt alternative cell fates during development. In Bacillus subtilis, the transition from planktonic growth to biofilm formation and sporulation is controlled by a complex regulatory circuit, in which the most important event is activation of Spo0A, a transcription factor and a master regulator for genes inv...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01025

    authors: Yan F,Yu Y,Wang L,Luo Y,Guo JH,Chai Y

    更新日期:2016-06-28 00:00:00

  • Salmonella Interaction with and Passage through the Intestinal Mucosa: Through the Lens of the Organism.

    abstract::Salmonella enterica serotypes are invasive enteric pathogens spread through fecal contamination of food and water sources, and represent a constant public health threat around the world. The symptoms associated with salmonellosis and typhoid disease are largely due to the host response to invading Salmonella, and to t...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2011.00088

    authors: Hallstrom K,McCormick BA

    更新日期:2011-04-29 00:00:00

  • The Lp_3561 and Lp_3562 Enzymes Support a Functional Divergence Process in the Lipase/Esterase Toolkit from Lactobacillus plantarum.

    abstract::Lactobacillus plantarum species is a good source of esterases since both lipolytic and esterase activities have been described for strains of this species. No fundamental biochemical difference exists among esterases and lipases since both share a common catalytic mechanism. L. plantarum WCFS1 possesses a protein, Lp_...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01118

    authors: Esteban-Torres M,Reverón I,Santamaría L,Mancheño JM,de Las Rivas B,Muñoz R

    更新日期:2016-07-19 00:00:00

  • Impact of elevated atmospheric O3 on the actinobacterial community structure and function in the rhizosphere of European beech (Fagus sylvatica L.).

    abstract::Many bacteria belonging to the phylum of Actinobacteria are known as antagonists against phytpathogenic microbes. This study aimed to analyze the effect of ozone on the actinobacterial community of the rhizosphere of four years old European beech (Fagus sylvatica L.) trees during different time points of the vegetatio...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2014.00036

    authors: Haesler F,Hagn A,Engel M,Schloter M

    更新日期:2014-02-11 00:00:00

  • Organic Amendment Under Increasing Agricultural Intensification: Effects on Soil Bacterial Communities and Plant Productivity.

    abstract::The soil microbiome is a complex living network that plays essential roles in agricultural systems, regardless of the level of intensification. However, the effects of agricultural management on the soil microbiome and the association with plant productivity remain largely unclear. Here, we studied the responses of th...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02612

    authors: Mas-Carrió E,Dini-Andreote F,Brossi MJL,Salles JF,Olff H

    更新日期:2018-10-31 00:00:00

  • SIV replication in human cells.

    abstract::Current human immunodeficiency virus type 1 pandemic is believed to originate from cross-species transmission of simian immunodeficiency virus (SIV) into human population. Such cross-species transmission, however, is not efficient in general, because viral replication is modulated by host cell factors, with the specie...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2012.00162

    authors: Sakuma R,Takeuchi H

    更新日期:2012-04-27 00:00:00

  • Dual Identification and Analysis of Differentially Expressed Transcripts of Porcine PK-15 Cells and Toxoplasma gondii during in vitro Infection.

    abstract::Toxoplasma gondii is responsible for causing toxoplasmosis, one of the most prevalent zoonotic parasitoses worldwide. The mechanisms that mediate T. gondii infection of pigs (the most common source of human infection) and renal tissues are still unknown. To identify the critical alterations that take place in the tran...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00721

    authors: Zhou CX,Elsheikha HM,Zhou DH,Liu Q,Zhu XQ,Suo X

    更新日期:2016-05-13 00:00:00

  • Impact of Soybean Nodulation Phenotypes and Nitrogen Fertilizer Levels on the Rhizosphere Bacterial Community.

    abstract::The effects of nodulation properties of legumes on the rhizosphere bacterial community are still not clear. To determine the effects of nodulation phenotypes on bacterial communities in the rhizosphere of soybean plants, we performed high-throughput sequencing of the 16S rRNA gene to estimate the rhizosphere bacterial...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00750

    authors: Wang H,Gu C,Liu X,Yang C,Li W,Wang S

    更新日期:2020-05-12 00:00:00

  • Pathobiomes Differ between Two Diseases Affecting Reef Building Coralline Algae.

    abstract::Crustose coralline algae (CCA) are major benthic calcifiers that play crucial roles in coral reef ecosystems. Two diseases affecting CCA have recently been investigated: coralline white band syndrome (CWBS) and coralline white patch disease (CWPD). These diseases can trigger major losses in CCA cover on tropical coral...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01686

    authors: Meistertzheim AL,Nugues MM,Quéré G,Galand PE

    更新日期:2017-09-01 00:00:00

  • Burn Injury Leads to Increase in Relative Abundance of Opportunistic Pathogens in the Rat Gastrointestinal Microbiome.

    abstract::The gastrointestinal microbiome is crucial in human health. With greater than 10 times the cell count of an individual, the gastrointestinal microbiome provides many benefits to the host. It plays an important role in chronic illnesses and immune diseases and also following burns and trauma. This study aimed to determ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01237

    authors: Huang G,Sun K,Yin S,Jiang B,Chen Y,Gong Y,Chen Y,Yang Z,Chen J,Yuan Z,Peng Y

    更新日期:2017-07-06 00:00:00

  • Bio-Decolorization of Synthetic Dyes by a Halophilic Bacterium Salinivibrio sp.

    abstract::Synthetic dyes, extensively used in various industries, act as pollutants in the aquatic environment, and pose a significant threat to living beings. In the present study, we assessed the potential of a halophilic bacterium Salinivibrio kushneri HTSP isolated from a saltpan for decolorization and bioremediation of syn...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.594011

    authors: John J,Dineshram R,Hemalatha KR,Dhassiah MP,Gopal D,Kumar A

    更新日期:2020-12-21 00:00:00

  • fbl-Typing of Staphylococcus lugdunensis: A Frontline Tool for Epidemiological Studies, but Not Predictive of Fibrinogen Binding Ability.

    abstract::Staphylococcus lugdunensis is increasingly recognized as a potent pathogen, responsible for severe infections with an outcome resembling that of Staphylococcus aureus. Here, we developed and evaluated a tool for S. lugdunensis typing, using DNA sequence analysis of the repeat-encoding region (R-domain) in the gene enc...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01109

    authors: Dahyot S,Lebeurre J,Laumay F,Argemi X,Dubos C,Lemée L,Prévost G,François P,Pestel-Caron M

    更新日期:2019-05-17 00:00:00

  • Epidemiological Characteristics and Environmental Risk Factors of Severe Fever with Thrombocytopenia Syndrome in Hubei Province, China, from 2011 to 2016.

    abstract::Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral disease affecting hundreds of people in China each year. To better understand the epidemiological characteristics and environmental risk factors associated with the incidence of SFTS in Hubei Province, China, we conducted a retrospective epidemio...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00387

    authors: Wang T,Li XL,Liu M,Song XJ,Zhang H,Wang YB,Tian BP,Xing XS,Li SY

    更新日期:2017-03-08 00:00:00

  • Depth and Dissolved Organic Carbon Shape Microbial Communities in Surface Influenced but Not Ancient Saline Terrestrial Aquifers.

    abstract::The continental deep biosphere is suggested to contain a substantial fraction of the earth's total biomass and microorganisms inhabiting this environment likely have a substantial impact on biogeochemical cycles. However, the deep microbial community is still largely unknown and can be influenced by parameters such as...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02880

    authors: Lopez-Fernandez M,Åström M,Bertilsson S,Dopson M

    更新日期:2018-11-27 00:00:00

  • InhA1-Mediated Cleavage of the Metalloprotease NprA Allows Bacillus cereus to Escape From Macrophages.

    abstract::Bacillus cereus is a Gram-positive spore-forming bacterium causing food poisoning and serious opportunistic infections. These infections are characterized by bacterial accumulation in the host despite the induction of inflammation. To circumvent inflammation, bacteria must resist the bactericidal activity of professio...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.01063

    authors: Haydar A,Tran SL,Guillemet E,Darrigo C,Perchat S,Lereclus D,Coquet L,Jouenne T,Ramarao N

    更新日期:2018-05-23 00:00:00

  • Anti-parasitic Peptides from Arthropods and their Application in Drug Therapy.

    abstract::Africa, Asia, and Latin America are regions highly affected by endemic diseases, such as Leishmaniasis, Malaria, and Chagas' disease. They are responsible for the death of 1000s of patients every year, as there is not yet a cure for them and the drugs used are inefficient against the pathogenic parasites. During the l...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2016.00091

    authors: Lacerda AF,Pelegrini PB,de Oliveira DM,Vasconcelos ÉA,Grossi-de-Sá MF

    更新日期:2016-02-05 00:00:00

  • Evaluation of Recombinant Multi-Epitope Outer Membrane Protein-Based Klebsiella pneumoniae Subunit Vaccine in Mouse Model.

    abstract::Safety and protective efficacy of recombinant multi-epitope subunit vaccine (r-AK36) was evaluated in a mouse model. Recombinant AK36 protein comprised of immunodominant antigens from outer membrane proteins (Omp's) of Klebsiella pneumoniae namely OmpA and OmpK36. r-AK36 was highly immunogenic and the hyperimmune sera...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01805

    authors: Babu L,Uppalapati SR,Sripathy MH,Reddy PN

    更新日期:2017-09-20 00:00:00

  • The Cultivable Surface Microbiota of the Brown Alga Ascophyllum nodosum is Enriched in Macroalgal-Polysaccharide-Degrading Bacteria.

    abstract::Bacteria degrading algal polysaccharides are key players in the global carbon cycle and in algal biomass recycling. Yet the water column, which has been studied largely by metagenomic approaches, is poor in such bacteria and their algal-polysaccharide-degrading enzymes. Even more surprisingly, the few published studie...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.01487

    authors: Martin M,Barbeyron T,Martin R,Portetelle D,Michel G,Vandenbol M

    更新日期:2015-12-24 00:00:00