[Optical and electron microscopic study of the kidney of dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi].

Abstract:

:Two naturally infected dogs (male and female) from Teófilo Otoni (MG-Brazil) were maintained for 18 months in our laboratory. Two other dogs, two months old males were infected with 1 x 10(6) promastigotes of MHO/BR/70/BH46 Leishmania (Leishmania) chagasi strain, endovenous route, and autopsied after 10 months and two years. The main findings concerning the kidney were: (1) focal or diffuse mesangial glomerulonephritis with proliferative and enlargement of mesangial cells; (2) increase in thickness of basement membrane with electron-dense deposits; (3) chronic interstitial nephritis with intense exudation of plasmocytes; (4) cloud swelling of renal tubules. The authors discuss the probable pathogenetic mechanisms.

authors

Tafuri WL,Michalick MS,Dias M,Genaro O,Leite VH,Barbosa AJ,Bambirra EA,da Costa CA,Melo MN,Mayrink W

doi

10.1590/s0036-46651989000300002

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

139-45

issue

3

eissn

0036-4665

issn

1678-9946

journal_volume

31

pub_type

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