Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response.

abstract：:Developmental effects of genistein (Gen) on the mammary gland were investigated using outbred female CD-1 mice treated neonatally on d 1-5 by sc injections at doses of 0.5, 5, or 50 mg/kg.d. Examination of mammary gland whole mounts (no. 4) before puberty (4 wk) revealed no morphological differences in development aft...

journal_title：Endocrinology

authors： Padilla-Banks E,Jefferson WN,Newbold RR

更新日期：2006-10-01 00:00:00

abstract：:We have recently found that, in the frog adrenal gland, endozepines are present in chromaffin cells and we have shown that the triakontatetraneuropeptide TTN is a potent stimulator of corticosteroid secretion in vitro. In the present study, we have investigated the transduction mechanisms mediating the corticotropic e...

journal_title：Endocrinology

authors： Lesouhaitier O,Kodjo MK,Cartier F,Contesse V,Yon L,Delarue C,Vaudry H

更新日期：2000-01-01 00:00:00

abstract：:To examine the role of the kidney in the catabolism of gut glucagon-like immunoreactivity (GLI), we compared the plasma GLI responses of normal and nephrectomized dogs given intraduodenal glucose loads and studied the clearance of gut GLI by the isolated perfused rat kidney. Both basal and postload plasma samples were...

journal_title：Endocrinology

authors： Rovira A,López-Novoa JM,Zubiaur M,Matesanz R,Ghiglione M,Pascual JM,Valverde I

更新日期：1982-06-01 00:00:00

abstract：:In addition to 17beta-estradiol binding, estrogen receptor (ER) transcriptional activity could be controlled by intracellular kinase signaling pathways activated by growth factors. In this report we present evidence suggesting that glycogen synthase kinase 3 (GSK3), an effector kinase of the phosphatidylinositol 3-kin...

journal_title：Endocrinology

authors： Mendez P,Garcia-Segura LM

更新日期：2006-06-01 00:00:00

abstract：:Oxytocin (OT) is a hypothalamic nonapeptide that is synthesized as part of a larger precursor protein that also contains an approximately 10-kDa protein called neurophysin at its C-terminus. This precursor protein is trafficked through the regulated secretory pathway into secretory granules and then axonally transport...

journal_title：Endocrinology

authors： Zhang BJ,Kusano K,Zerfas P,Iacangelo A,Young WS 3rd,Gainer H

更新日期：2002-03-01 00:00:00

abstract：:Germ cells were isolated from 30-day-old rat testes and purified by a Percoll gradient. Germ cells were cultured for 24 h to eliminate contaminant cells by utilizing the property of many nongerm cells of attaching to plastic surfaces. Germ cells were subsequently seeded on top of 7-day-old Sertoli cell monolayers. RNA...

journal_title：Endocrinology

authors： Rivarola MA,Sanchez P,Saez JM

更新日期：1985-11-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) is expressed in many neuronal and non-neuronal tissues during development as well as in adult animals. GDNF signaling is mediated through a two-component system consisting of the so called GDNF receptor-alfa (GFRalpha1) which binds to GDNF. Thereafter this complex bin...

journal_title：Endocrinology

authors： Urbano AG,Suárez-Peñaranda JM,Diéguez C,Alvarez CV

更新日期：2000-05-01 00:00:00

abstract：:As4.1 cells are derived from a renin-expressing kidney tumor induced by tissue-specific oncogene-mediated tumorigenesis in transgenic mice. These cells express high levels of renin messenger RNA (mRNA) and synthesize prorenin and renin; they were therefore used as a model to further investigate the molecular biology o...

journal_title：Endocrinology

authors： Thompson HA,Burson JM,Lang JA,Gross KW,Sigmund CD

更新日期：1995-07-01 00:00:00

abstract：:Metastatic pheochromocytoma continues to be an incurable disease, and treatment with conventional cytotoxic chemotherapy offers limited efficacy. In the present study, we evaluated a novel topoisomerase I inhibitor, LMP-400, as a potential treatment for this devastating disease. We found a high expression of topoisome...

journal_title：Endocrinology

authors： Schovanek J,Bullova P,Tayem Y,Giubellino A,Wesley R,Lendvai N,Nölting S,Kopacek J,Frysak Z,Pommier Y,Kummar S,Pacak K

更新日期：2015-11-01 00:00:00

abstract：:The development of acquired resistance to antihormonal agents in breast cancer is a major therapeutic problem. We have developed a tamoxifen-resistant (TAM-R) MCF-7 breast cancer cell line to investigate the mechanisms behind this condition. Both epidermal growth factor receptor (EGFR) and c-erbB2 mRNA and protein exp...

journal_title：Endocrinology

authors： Knowlden JM,Hutcheson IR,Jones HE,Madden T,Gee JM,Harper ME,Barrow D,Wakeling AE,Nicholson RI

更新日期：2003-03-01 00:00:00

abstract：:The 3'5'-cyclic GMP (cGMP) pathway is known to influence ovarian functions, including steroidogenesis, ovulation, and granulosa cell proliferation. We show here that cGMP-phosphodiesterase (PDE) activity increased in a gonadotropin-dependent manner more than 3-fold in the cumulus-oocyte complex (COC) after 24 h in vit...

journal_title：Endocrinology

authors： Sasseville M,Côté N,Gagnon MC,Richard FJ

更新日期：2008-11-01 00:00:00

abstract：:This study aimed to delineate the hypothalamic and/or pituitary actions of testosterone and its primary metabolites 5 alpha-dihydrotestosterone and estradiol (E) in adult castrated rams (wethers) during the breeding season. In Exp 1, wethers were treated for a week with twice daily injections (im) of peanut oil, 8, 16...

journal_title：Endocrinology

authors： Tilbrook AJ,de Kretser DM,Cummins JT,Clarke IJ

更新日期：1991-12-01 00:00:00

abstract：:The hepatic extractions of gastric inhibitory polypeptide (GIP) and insulin were determined using in vitro and in vivo methods to assess the role of the liver in GIP metabolism and the possible effect of GIP on the hepatic extraction of insulin. During in vitro studies using the isolated perfused rat liver, infusion o...

journal_title：Endocrinology

authors： Hanks JB,Andersen DK,Wise JE,Putnam WS,Meyers WC,Jones RS

更新日期：1984-09-01 00:00:00

abstract：:Fibrosis (extracellular matrix accumulation) is the final end point in diabetic cardiomyopathy. The current study evaluated the therapeutic effects of the antifibrotic hormone relaxin (RLX) in streptozotocin-treated transgenic mRen-2 rats, which undergo pathological and functional features similar to human diabetes. T...

journal_title：Endocrinology

authors： Samuel CS,Hewitson TD,Zhang Y,Kelly DJ

更新日期：2008-07-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) is thought to confer aldosterone specificity to mineralocorticoid target cells by protecting the mineralocorticoid receptor from occupancy by endogenous glucocorticoids. We have recently described a novel isoform of 11-OHSD in the renal aldosterone target cells (11 b...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Fejes-Tóth G

更新日期：1995-06-01 00:00:00

abstract：:Sertoli cell intracellular protein 1 (SCc1) and 2 (SCc2) are polypeptides found in rat Sertoli cell cultures incubated with either FSH or (Bu)2cAMP. They were first identified in [35S]methionine-labeled Sertoli cell lysates using two-dimensional gel electrophoresis. Here we extend these observations by showing that SC...

journal_title：Endocrinology

authors： Gregory CW,DePhilip RM

更新日期：1992-11-01 00:00:00

abstract：:Swine granulosa cells cultured under serum-free conditions in vitro exhibit significant responsivity to the stimulatory actions of estradiol (E2) and FSH or LH. Under these conditions, granulosa cells harvested from either immature or mature Graafian follicles synthesized significantly increased quantities of progeste...

journal_title：Endocrinology

authors： Veldhuis JD,Gwynne JT,Strauss JF 3rd,Demers LM

更新日期：1984-06-01 00:00:00

abstract：:The influence of administration of ovine prolactin in vivo on intestinal fluid and ion transport in vitro was investigated using intact and hypophysectomized male rats. Prolactin administration significantly stimulated fluid, sodium,potassium, calcium, magnesium and chloride transport across everted jejunal sacs. The ...

journal_title：Endocrinology

authors： Mainoya JR

更新日期：1975-05-01 00:00:00

abstract：:The mouse mammary gland and uterus expressed the gene for the secretory protein lactotransferrin under various physiological conditions. Lactotransferrin, however, was induced by estrogen in a time- and dose-dependent fashion in the uterus of the immature mouse, but was not affected by estrogen in the mammary gland. D...

journal_title：Endocrinology

authors： Teng CT,Pentecost BT,Chen YH,Newbold RR,Eddy EM,McLachlan JA

更新日期：1989-02-01 00:00:00

abstract：:Estrogen receptor α (ESR1; encoded by Esr1) is a crucial nuclear transcription factor for female reproduction and is expressed throughout the female reproductive tract. To assess the function of ESR1 in reproductive tissues without confounding effects from a potential developmental defect arising from global deletion ...

journal_title：Endocrinology

authors： Herrera GGB,Lierz SL,Harris EA,Donoghue LJ,Hewitt SC,Rodriguez KF,Jefferson WN,Lydon JP,DeMayo FJ,Williams CJ,Korach KS,Winuthayanon W

更新日期：2020-02-01 00:00:00

abstract：:Insulin-like growth factors I and II (IGF-I and -II) are polypeptides secreted by skeletal cells and are considered regulators of bone formation. IGF-I and -II were studied for their effects on collagen synthesis and degradation in cultures of intact fetal rat calvariae and on type I collagen transcript levels in oste...

journal_title：Endocrinology

authors： McCarthy TL,Centrella M,Canalis E

更新日期：1989-01-01 00:00:00

abstract：:This study uses a high purity cell culture system to extend previous observations of factors controlling the end of the Sertoli cell proliferative phase. Thyroid hormone, retinoic acid, and testosterone were assessed for their ability to halt the proliferative phase and regulate the expression of markers associated wi...

journal_title：Endocrinology

authors： Buzzard JJ,Wreford NG,Morrison JR

更新日期：2003-09-01 00:00:00

abstract：:Corticosteroids stimulate and insulin inhibits energy acquisition (food intake); conversely, corticosteroids inhibit and insulin stimulates energy storage (body weight gain). Thus, together these hormones mediate long-term energy balance. This study tested whether the stimulatory action of corticosteroids on food inta...

journal_title：Endocrinology

authors： Santana P,Akana SF,Hanson ES,Strack AM,Sebastian RJ,Dallman MF

更新日期：1995-05-01 00:00:00

abstract：:Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes. Elevated cytokines impair beta-cell function and survival. A recent clinical trial shows that blocking IL-1beta signaling by IL-1 receptor antagonist (IL-1Ra) improves beta-cell secretory function in patients with type 2 diabetes. In the ...

journal_title：Endocrinology

authors： Sauter NS,Schulthess FT,Galasso R,Castellani LW,Maedler K

更新日期：2008-05-01 00:00:00

abstract：:Exposure to testosterone (T) during d 30-90 of fetal life results in low-birth-weight offspring, hypergonadotropism, multifollicular ovaries, and early cessation of cyclicity. The multifollicular phenotype may result from failure of follicles to regress and consequent follicular persistence or, alternatively, increase...

journal_title：Endocrinology

authors： Steckler T,Wang J,Bartol FF,Roy SK,Padmanabhan V

更新日期：2005-07-01 00:00:00

abstract：:There is evidence that the IGF system plays an important role in the growth and function of the thyroid gland. Proteolysis is an important posttranslational process that modulates the affinity of IGF binding proteins (IGFBPs) to IGFs, thus regulating their activity. IGFBP-3 has been shown to be cleaved by members of t...

journal_title：Endocrinology

authors： Wang J,Grünler J,Lewitt MS

更新日期：2004-03-01 00:00:00

abstract：:This investigation examined the effects of repeated injections of LH on ovarian function in the immature sheep approximately 12 weeks before the time of the first expected spontaneous ovulation. The frequency of endogenous LH pulses during the pretreatment period was approximately one pulse each 3 h. The first experim...

journal_title：Endocrinology

authors： Foster DL,Ryan KD,Papkoff H

更新日期：1984-09-01 00:00:00

abstract：:The lactogen-dependent rat Nb2 lymphoma is a useful model to investigate PRL signaling pathways that lead to regulation of gene transcription. A primary mechanism coupled to PRL receptor (PRLR) activation in Nb2 cells involves phosphorylation by Jak-family tyrosine kinases of one or more signal transducers and activat...

journal_title：Endocrinology

authors： Borg KE,Zhang M,Hegge D,Stephen RL,Buckley DJ,Magnuson NS,Buckley AR

更新日期：1999-12-01 00:00:00

abstract：:Daily nocturnal (N) and diurnal (D) surges of PRL are characteristic of a pseudopregnancy (psp) induced by cervical stimulation (CS). These semicircadian surges persist for 13-14 days, after which time they cease, and psp ends. The purpose of this study was to describe the involvement of the ovarian steroids in the ma...

journal_title：Endocrinology

authors： Gorospe WC,Freeman ME

更新日期：1981-04-01 00:00:00

abstract：:Hypothyroid patients and mice have been shown to have circulating TSH that is more highly sialylated than their euthyroid counterparts. To learn about the underlying cellular mechanisms responsible for this increased sialylation of TSH, we used in situ hybridization to examine the beta-galactoside alpha-2,6-sialyltran...

journal_title：Endocrinology

authors： Helton TE,Magner JA

更新日期：1994-06-01 00:00:00