Abstract:
PURPOSE OF REVIEW:Traumatic brain injury (TBI) is a leading cause of death and disability in children. Prognostication of outcome following TBI is challenging in this population and likely requires complex, multimodal models to achieve clinically relevant accuracy. This review highlights injury characteristics, physiological indicators, biomarkers and neuromonitoring modalities predictive of outcome that may be integrated for future development of sensitive and specific prognostic models. RECENT FINDINGS:Paediatric TBI is responsible for physical, psychosocial and neurocognitive deficits that may significantly impact quality of life. Outcome prognostication can be difficult in the immature brain, but is aided by the identification of novel biomarkers (neuronal, astroglial, myelin, inflammatory, apoptotic and autophagic) and neuromonitoring techniques (electroencephalogram and MRI). Investigation in the future may focus on assessing the prognostic ability of combinations of biochemical, protein, neuroimaging and functional biomarkers and the use of mathematical models to develop multivariable predication tools to improve the prognostic ability following childhood TBI. SUMMARY:Prognostication of outcome following paediatric TBI is multidimensional, influenced by injury severity, age, physiological factors, biomarkers, electroencephalogram and neuroimaging. Further development, integration and validation of combinatorial prognostic algorithms are necessary to improve the accuracy and timeliness of prognosis in a meaningful fashion.
journal_name
Curr Opin Neuroljournal_title
Current opinion in neurologyauthors
Au AK,Clark RSBdoi
10.1097/WCO.0000000000000504subject
Has Abstractpub_date
2017-12-01 00:00:00pages
565-572issue
6eissn
1350-7540issn
1473-6551journal_volume
30pub_type
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
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journal_title:Current opinion in neurology
pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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更新日期:2012-08-01 00:00:00
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journal_title:Current opinion in neurology
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doi:10.1097/01.wco.0000073925.19076.f2
更新日期:2003-06-01 00:00:00
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journal_title:Current opinion in neurology
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doi:10.1097/00019052-199808000-00010
更新日期:1998-08-01 00:00:00
abstract::This is a review of chemotherapy options for patients with brain tumors, both at the time of initial diagnosis and at recurrence. Gliomas, the most common malignant brain tumors, represent the main focus of the review; chemotherapeutic options for supratentorial, brain stem, and optic track gliomas are discussed. ...
journal_title:Current opinion in neurology
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