Anxiolytic-like effects of α-asarone in a mouse model of chronic pain.

abstract：:The role of oxidative stress in the pathogenesis of phenylketonuria (PKU)-associated disorders has been implicated. Ischemia modified albumin (IMA) is a modified form of serum albumin, which is produced under the conditions of oxidative stress. The aim of this study was to measure the serum level of IMA in the PKU pat...

journal_title：Metabolic brain disease

authors： Keshavarzi F,Rastegar M,Vessal M,Rafiei Dehbidi G,Khorsand M,Ganjkarimi AH,Takhshid MA

更新日期：2018-06-01 00:00:00

abstract：:The central nervous system is one of the most vulnerable organs affected by mercury toxicity. Both acute and chronic exposure to mercury is also known to cause a variety of neurological or psychiatric disorders. Here, the neuroprotective effect of berberine (BN; 100 mg/kg bwt) on mercuric chloride (HgCl2; 0.4 mg/kg bw...

journal_title：Metabolic brain disease

authors： Abdel Moneim AE

更新日期：2015-08-01 00:00:00

abstract：:Substantial evidence demonstrated that maternal dietary nutrients can significantly determine the susceptibility to developing metabolic disorders in the offspring. Therefore, we aimed to investigate the later-life effects of maternal and postweaning diets interaction on epigenetic modification of the central nervous ...

journal_title：Metabolic brain disease

authors： Zheng J,Xiao X,Zhang Q,Yu M,Xu J,Wang Z,Qi C,Wang T

更新日期：2015-10-01 00:00:00

abstract：:It has been suggested that alterations of GABAergic neurotransmission are implicated in the pathophysiology of hepatic encephalopathy (HE). Increased concentrations of endogenous benzodiazepines with positive allosteric modulatory properties at the GABA-A receptor complex were proposed as a pathophysiological mechanis...

journal_title：Metabolic brain disease

authors： Ahboucha S,Pomier-Layrargues G,Butterworth RF

更新日期：2004-12-01 00:00:00

abstract：:Cerebral inflammation plays a role in diseases such as multiple sclerosis (MS), Alzheimer's disease (AD), and depression. Iron is involved in infection and inflammation through free radical production. Theoretically transferrin should prohibit iron from participating in oxidative reactions, but transferrin has also be...

journal_title：Metabolic brain disease

authors： van Rensburg SJ,van Zyl J,Hon D,Daniels W,Hendricks J,Potocnik F,Erasmus R

更新日期：2004-06-01 00:00:00

abstract：:Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism ...

journal_title：Metabolic brain disease

authors： Yan X,Lukas J,Witt M,Wree A,Hübner R,Frech M,Köhling R,Rolfs A,Luo J

更新日期：2011-12-01 00:00:00

abstract：:Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism. Usually diagnosed within the first month of birth, it is essential that the patient strictly follow the dietary restriction of natural protein intake. Otherwise, PKU impacts the development of the brain severely and may result in microceph...

journal_title：Metabolic brain disease

authors： Bortoluzzi VT,Brust L,Preissler T,de Franceschi ID,Wannmacher CMD

更新日期：2019-12-01 00:00:00

abstract：:The impaired insulin signaling has been recognized as a common pathogenetic mechanism between diabetes and Alzheimer's disease (AD). In the progression of AD, brain is characterized by defective insulin receptor substrate-1 (IRS-1) and increased oxidative stress. Thymol, a monoterpene phenol isolated from medicinal he...

journal_title：Metabolic brain disease

authors： FangFang,Li H,Qin T,Li M,Ma S

更新日期：2017-04-01 00:00:00

abstract：:Ischemic postconditioning (IPostC) has been reported to have neuroprotection against ischemic diseases, and one cycle of IPostC induces neurogenesis when treated nearby. To expanding these effects, we explored the effects of repetitively remote IPostC (NRIPostC) on neurogenesis in the subgranular zone (SGZ) and subent...

journal_title：Metabolic brain disease

authors： Huang D,Liu H,Qu Y,Wang P

更新日期：2017-12-01 00:00:00

abstract：:While alcohol-induced psychotic disorder (AIPD) is well recognised, relatively little is known about the condition. We undertook a review of the literature to identify studies on the epidemiology, clinical manifestations, underlying neurobiology and treatment of AIPD. Few prospective studies have been conducted on AIP...

journal_title：Metabolic brain disease

authors： Jordaan GP,Emsley R

更新日期：2014-06-01 00:00:00

abstract：:Glutamate neurotoxicity was studied in primary neuronal cultures prepared from rat cerebral cortex and hippocampal CA1 sector. Neurons were cultivated with 5% native horse serum and then exposed to 0.1 or 1.0 mM glutamate for 5 min. Subsequently, neurons were allowed to recover for 24 hours either in the presence or i...

journal_title：Metabolic brain disease

authors： Uto A,Dux E,Hossmann KA

更新日期：1994-12-01 00:00:00

abstract：:We report reversible abnormalities in magnetic resonance spectra acquired from a patient with AIDS undergoing antibiotic and corticosteroid therapy for disseminated nocardiosis, a rare opportunistic infection of immunosuppressed patients which can cause cerebral abscess formation. There was no clinical, CT or MRI evid...

journal_title：Metabolic brain disease

authors： Marcus CD,Taylor-Robinson SD,Cox IJ,Sargentoni J,Shaunak S

更新日期：1999-12-01 00:00:00

abstract：:Depression is a complex progressive disorder accompanied by activation of inflammatory and Th-1 driven pathways, oxidative and nitrosative stress (O&NS), lowered antioxidant levels, mitochondrial dysfunctions, neuroprogression and increased bacterial translocation. In depression, activation of immuno-inflammatory path...

journal_title：Metabolic brain disease

authors： Maes M

更新日期：2012-12-01 00:00:00

abstract：:Neuroinflammation has been recognized as a major contributor to brain injury caused by intracerebral hemorrhage (ICH). Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome acts as an important mediator of inflammatory response in various inflammation-related dis...

journal_title：Metabolic brain disease

authors： Cheng Y,Wei Y,Yang W,Song Y,Shang H,Cai Y,Wu Z,Zhao W

更新日期：2017-08-01 00:00:00

abstract：:Previous studies have been conducted to explore the association between proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia (SZ) susceptibility, but providing the controversial results. Here we performed this meta-analysis to determine whether PRODH variants were associated with SZ risk. Relevant studie...

journal_title：Metabolic brain disease

authors： Guo X,Tang P,Yang C,Li R

更新日期：2018-02-01 00:00:00

abstract：:In the current era, plants are frequently tested for its antidepressant potential. Therefore young coconut water, a commonly used plant based beverage, was selected to explore its antidepressant potential. Rodents were selected for this study and forced swim test was conducted to explore antidepressant activity. Analy...

journal_title：Metabolic brain disease

authors： Rao SS,Najam R

更新日期：2016-10-01 00:00:00

abstract：:Increasing evidence indicates that excessive drug consumption is sufficient for the transition from recreational and controlled drug use to uncontrolled use and addiction. However, the underlying mechanisms are debated. Some neurobehavioral and neuroimaging evidence indicates that dorsolateral striatum (dlStr)-depende...

journal_title：Metabolic brain disease

authors： Shi JJ,Cao DN,Liu HF,Wang ZY,Lu GY,Wu N,Zhou WH,Li J

更新日期：2019-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) is accompanied with enhanced matrix metalloproteinase-9 (MMP-9) activity and elevated levels of plasma fibrinogen (Fg), which is a known inflammatory agent. Activation of MMP-9 and increase in blood content of Fg (i.e. hyperfibrinogenemia, HFg) both contribute to cerebrovascular disorders ...

journal_title：Metabolic brain disease

authors： Muradashvili N,Benton RL,Saatman KE,Tyagi SC,Lominadze D

更新日期：2015-04-01 00:00:00

abstract：:In this work, we evaluated the effects of Psidium cattleianum (Red Type) (PcRT) fruit extract on metabolic, behavioral, and neurochemical parameters in rats fed with a highly palatable diet (HPD) consisted of sucrose (65% carbohydrates being 34% from condensed milk, 8% from sucrose and 23% from starch, 25% protein and...

journal_title：Metabolic brain disease

authors： Oliveira PS,Chaves VC,Soares MSP,Bona NP,Mendonça LT,Carvalho FB,Gutierres JM,Vasconcellos FA,Vizzotto M,Vieira A,Spanevello RM,Reginatto FH,Lencina CL,Stefanello FM

更新日期：2018-10-01 00:00:00

abstract：:Mutations in the HTT gene, consisting of expansion of CAG triplets, cause the Huntington's disease (HD), one of the major neurodegenerative disorders. Formation of aggregates of mutant huntingtin (mHTT, the product of the mutant HTT gene) leads to cellular dysfunctions, and subsequent neurodegeneration which manifest ...

journal_title：Metabolic brain disease

authors： Pierzynowska K,Gaffke L,Cyske Z,Węgrzyn G

更新日期：2019-06-01 00:00:00

abstract：:The present work was carried out to study the influence of ammonia and factors from sera and cerebrospinal fluid (CSF) from patients with different degrees of chronic liver diseases on [3H]D-aspartate (Asp) and [3H]L-glutamate (Glu) high-affinity uptake into the rat hippocampal formation. For comparison, high-affinity...

journal_title：Metabolic brain disease

authors： Schmidt W,Wolf G,Grüngreiff K,Meier M,Reum T

更新日期：1990-03-01 00:00:00

abstract：:As studies of brain metabolism grow in complexity, investigators turn increasingly to nuclear magnetic resonance spectroscopy combined with 13C isotopic labeling. The unique ability to detect labeling non-destructively in specific carbon positions of individual compounds has opened the way to investigate brain metabol...

journal_title：Metabolic brain disease

authors： Mason GF,Behar KL,Lai JC

更新日期：1996-12-01 00:00:00

abstract：:To characterize an Egyptian patient with glutaric acidemia type I (GA I) and to identify the causative mutation(s) that may be responsible for the disease phenotype. MRI was performed on the patient using the 1.5 T magnet, biochemical analysis was carried out using gas chromatography/mass spectrometry on the patient's...

journal_title：Metabolic brain disease

authors： Moseilhy A,Hassan MM,El Abd HS,Mohammad SA,El Bekay R,Abdel-Motal UM,Ouhtit A,Zaki OK,Zayed H

更新日期：2017-02-01 00:00:00

abstract：:Despite many clinical trials assessing the role of zinc in major depressive disorder (MDD), the conclusions still remain ambiguous. The aim of the present clinical study was to determine and comparison the zinc concentration in the blood of MDD patients (active stage or remission) and healthy volunteers (controls), as...

journal_title：Metabolic brain disease

authors： Styczeń K,Sowa-Kućma M,Siwek M,Dudek D,Reczyński W,Szewczyk B,Misztak P,Topór-Mądry R,Opoka W,Nowak G

更新日期：2017-02-01 00:00:00

abstract：:Depression, common in chronic medical conditions, and hepatic encephalopathy (HE), a reversible neuropsychiatric syndrome due to liver dysfunction, are associated with impaired health-related quality of life (HRQOL) in cirrhosis and hepatitis C (HCV). This study investigated the impact of depression and HE on HRQOL in...

journal_title：Metabolic brain disease

authors： Barboza KC,Salinas LM,Sahebjam F,Jesudian AB,Weisberg IL,Sigal SH

更新日期：2016-08-01 00:00:00

abstract：:Spontaneous intracerebral hemorrhage (ICH) represents a partially-understood cerebrovascular disease of high incidence, morbidity and mortality. We, herein, report the findings of our study concerning the role of two important adenosinetriphosphatases (ATPases) in a porcine model of spontaneous ICH that we have recent...

journal_title：Metabolic brain disease

authors： Bimpis A,Papalois A,Tsakiris S,Kalafatakis K,Zarros A,Gkanti V,Skandali N,Al-Humadi H,Kouzelis C,Liapi C

更新日期：2013-09-01 00:00:00

abstract：:Glutaric aciduria type 1 is a neurometabolic disorder, caused by riboflavin-dependent glutaryl-CoA dehydrogenase deficiency. As its consequence, accumulation of the putatively neurotoxic metabolites (glutaric and 3-hydroxyglutaric acids) in body tissues, but especially within the brain, is observed. Estimated incidenc...

journal_title：Metabolic brain disease

authors： Pokora P,Jezela-Stanek A,Różdżyńska-Świątkowska A,Jurkiewicz E,Bogdańska A,Szymańska E,Rokicki D,Ciara E,Rydzanicz M,Stawiński P,Płoski R,Tylki-Szymańska A

更新日期：2019-04-01 00:00:00

abstract：:In the original publication of the article, author name Masoumeh Asadbegi was incorrectly written as Masoumeh Asadbeigi. The authors regret the oversight. ...

journal_title：Metabolic brain disease

authors： Sajadi A,Amiri I,Gharebaghi A,Komaki A,Asadbegi M,Shahidi S,Mehdizadeh M,Asl SS

更新日期：2017-12-01 00:00:00

abstract：:The present study aimed to investigate the role of vascular endothelial growth factor (VEGF) in the neuroprotective effect of Crocus sativus (saffron) against cerebral ischemia/reperfusion injury (I/R) in rats. Four groups of a total forty I/R rats with 60-min occlusion followed by 48 h reperfusion or sham surgery wer...

journal_title：Metabolic brain disease

authors： Abdel-Rahman RF,El Awdan SA,Hegazy RR,Mansour DF,Ogaly HA,Abdelbaset M

更新日期：2020-03-01 00:00:00

abstract：:Due to the high ability of cadmium to cross the blood-brain barrier, cadmium (Cd) causes severe neurological damages. Hence, the purpose of this study was to investigate the possible protective effect of Mangifera indica leaf extract (MLE) against Cd-induced neurotoxicity. Rats were divided into eight groups. Group 1 ...

journal_title：Metabolic brain disease

authors： Al Omairi NE,Radwan OK,Alzahrani YA,Kassab RB

更新日期：2018-08-01 00:00:00