Abstract:
:'Candidatus Rickettsia amblyommii' is a spotted fever group rickettsia that is not considered pathogenic, although there is serologic evidence of possible infection in animals and humans. The aim of this study was to evaluate the pathogenic potential of a Costa Rican strain of 'Candidatus R. amblyommii' in guinea pigs and determine its capacity to generate protective immunity against a subsequent infection with a local strain of Rickettsia rickettsii isolated from a human case. Six guinea pigs were inoculated with 'Candidatus R. amblyommii' strain 9-CC-3-1 and two controls with cell culture medium. Health status was evaluated, and necropsies were executed at days 2, 4, and 13. Blood and tissues were processed by PCR to detect the gltA gene, and end titers of anti-'Candidatus R. amblyommii' IgG were determined by indirect immunofluorescence. To evaluate protective immunity, another 5 guinea pigs were infected with 'Candidatus R. amblyommii' (IGPs). After 4 weeks, these 5 IGPs and 3 controls (CGPs) were inoculated with pathogenic R. rickettsii. Clinical signs and titers of anti-Rickettsia IgG were determined. IgG titers reached 1:512 at day 13 post-infection with 'Candidatus R. amblyommii'. On day 2 after inoculation, two guinea pigs had enlarged testicles and 'Candidatus R. amblyommii' DNA was detected in testicles. Histopathology confirmed piogranulomatous orchitis with perivascular inflammatory infiltrate in the epididymis. In the protective immunity assay, anti-Rickettsia IgG end titers after R. rickettsii infection were lower in IGPs than in CGPs. IGPs exhibited only transient fever, while CGP showed signs of severe disease and mortality. R. rickettsii was detected in testicles and blood of CGPs. Results show that the strain 9-CC-3-1 of 'Candidatus R. amblyommii' was able to generate pathology and an antibody response in guinea pigs. Moreover, its capacity to generate protective immunity against R. rickettsii may modulate the epidemiology and severity of Rocky Mountain spotted fever in areas where both species circulate.
journal_name
Ticks Tick Borne Disjournal_title
Ticks and tick-borne diseasesauthors
Rivas JJ,Moreira-Soto A,Alvarado G,Taylor L,Calderón-Arguedas O,Hun L,Corrales-Aguilar E,Morales JA,Troyo Adoi
10.1016/j.ttbdis.2015.07.008subject
Has Abstractpub_date
2015-09-01 00:00:00pages
805-11issue
6eissn
1877-959Xissn
1877-9603pii
S1877-959X(15)00138-7journal_volume
6pub_type
杂志文章abstract::Amblyomma mixtum Koch, 1844 parasitizes livestock, humans, and wildlife in Mexico. However, information on population genetics for this tick species in the country is missing. Tick samples were collected from livestock in ten regions across the state of Veracruz (22°28'N, 17°09'S, 93°36'E, 98°39'W) to analyze the gene...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2018.09.004
更新日期:2019-01-01 00:00:00
abstract::In the present study, the presence of tick-associated bacteria and protozoa in Ornithodoros rostratus ticks (adults, nymphs, and eggs) from the Pantanal region of Brazil were determined by molecular detection. In these ticks, DNA from protozoa in the genera Babesia and Hepatozoon, and bacteria from the genera Ricketts...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2012.02.003
更新日期:2012-09-01 00:00:00
abstract::Rickettsia amblyommatis is widely distributed in the Americas, and has been reported to infect different species of ticks within its distribution. In Panama, R. amblyommatis is the most common Rickettsia and its presence was molecularly detected in nine species of ticks and one flea species. This work described the is...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2020.101597
更新日期:2021-01-01 00:00:00
abstract::The entomopathogenic fungus Metarhizium anisopliae is used as a biological pest control agent against various arthropod species, including ticks. However, the efficacy depends on tick species, tick stage and fungus strain. We studied the effect of M. anisopliae on engorged larvae and nymphs of Ixodes ricinus, the most...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2016.03.010
更新日期:2016-07-01 00:00:00
abstract::Understanding the mechanism of pathogen transmission is essential for the development of strategies to reduce arthropod-borne diseases. The pharmaco- and immunomodulatory properties of insect and acarine saliva play an essential role in the efficiency of pathogen transmission. The skin as the site where arthropod sali...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2018.12.005
更新日期:2019-02-01 00:00:00
abstract::Vector-borne pathogens are transmitted between vertebrate hosts and arthropod vectors, two immensely different environments for the pathogen. There is further differentiation among vertebrate hosts that often have complex, species-specific immunological responses to the pathogen. All this presents a heterogeneous envi...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2015.03.011
更新日期:2015-04-01 00:00:00
abstract::The seasonal risk to humans of picking up Ixodes ricinus ticks in different habitats at 3 recreational sites in the UK was assessed. A comprehensive range of vegetation types was sampled at 3-weekly intervals for 2 years, using standard blanket-dragging complemented by woollen leggings and square 'heel flags'. Ticks w...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2011.03.002
更新日期:2011-06-01 00:00:00
abstract::The current work evaluated road-killed Pampas foxes (Lycalopex gymnocercus) and their ticks for the presence of vector-borne agents in the ecoregion Esteros del Iberá in northeastern Argentina. Spleen, lung and blood samples and Amblyomma tigrinum adult ticks collected from the foxes were tested by polymerase chain re...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2019.101318
更新日期:2020-03-01 00:00:00
abstract::Natural enemies of ticks include the parasitoid wasp Ixodiphagus hookeri (Hymenoptera: Encyrtidae). The aim of this preliminary study was to investigate the occurrence of I. hookeri DNA in a community of ticks (Ixodes ricinus, Dermacentor marginatus, Hyalomma marginatum, Haemaphysalis inermis and Rhipicephalus turanic...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2015.01.001
更新日期:2015-04-01 00:00:00
abstract::Information on Anaplasma phagocytophilum in Brazil is very restricted. The aim of this study was to report clinical, parasitological, hematological and molecular evidence of a natural A. phagocytophilum infection of an urban Brazilian dog. The dog was an eight-month-old male French bulldog. Veterinary clinical examina...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2015.01.003
更新日期:2015-04-01 00:00:00
abstract::Anaplasma phagocytophilum is an obligate intracellular and tick-transmitted bacterium, which causes granulocytic anaplasmosis in animals and humans. Although infection with A. phagocytophilum in domestic animals and vector ticks is documented, there is sparse information on the occurrence of A. phagocytophilum in wild...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2013.11.001
更新日期:2014-04-01 00:00:00
abstract::Anaplasma marginale infections are responsible for widespread morbidity and mortality particularly in crossbred and exotic breeds of cattle in the tropics and subtropics. In the present study, a semi-nested PCR assay was utilized for the detection of A. marginale infection in carrier cattle from different areas of Pun...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2011.10.002
更新日期:2012-02-01 00:00:00
abstract::The protozoan Hepatozoon canis, which is transmitted via ingestion of infected ticks by canine hosts, is not endemic to mid-latitude regions in Europe. Its distribution is supposed to be linked to the occurrence of its primary tick vector Rhipicephalus sanguineus. A young male golden jackal (Canis aureus) found as roa...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2012.10.040
更新日期:2013-02-01 00:00:00
abstract::The hard tick Ixodes ricinus is the principal vector of Lyme borreliosis (LB) group spirochaetes in Europe, but it also transmits a large number of other microbial pathogens that are of importance to animal and human health. Here, we characterise geographically distinct populations of this important ectoparasite based...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2013.10.001
更新日期:2014-03-01 00:00:00
abstract::This study is the first report about the prevalence of tick-borne pathogens, as well as their (co-)infection rates, in the museum-archived I. ricinus female ticks collected in Moldova in 1960. A total of 16.7% (21/126) ticks was mono-infected. Borrelia burgdorferi sensu stricto was revealed as the most abundant specie...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2012.12.004
更新日期:2013-06-01 00:00:00
abstract::We sequenced the entire mitochondrial genomes of 3 species of metastriate ticks: Haemaphysalis formosensis, H. parva, and Amblyomma cajennense. We also sequenced two thirds (ca. 9500bp) of the mitochondrial genomes of H. humerosa and H. hystricis. We used these 5 mitochondrial genome sequences together with the 13 tic...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2013.02.002
更新日期:2013-06-01 00:00:00
abstract::Crimean-Congo hemorrhagic fever (CCHF) is an acute tick-borne viral zoonotic disease which is endemic in Turkey. Bradycardia has been reported among pediatric and adult patients with CCHF. But, it remains unclear, whether bradycardia is associated with ribavirin treatment or the severity of CCHF. In this study 26 hosp...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2014.12.003
更新日期:2015-03-01 00:00:00
abstract::Tick-borne encephalitis virus (TBEV) is a zoonotic agent causing severe encephalitis in humans. A wide range of animal species could be infected with TBEV in endemic areas. A serological survey of wild animals is effective in identifying TBEV-endemic areas. Safe, simple, and reliable TBEV serodiagnostic tools are need...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2016.03.002
更新日期:2016-07-01 00:00:00
abstract::Acaricide resistance is one of the greatest threats towards the successful control of vector ticks worldwide. Communal farmers of Zimbabwe use amitraz as the most common acaricide with occasional usage of pyrethroids and organophosphates. As a strategy towards developing an effective acaricide resistance management sy...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2017.10.017
更新日期:2018-01-01 00:00:00
abstract::Rhipicephalus sanguineus sensu lato (s.l.) ticks act as intermediate host for a range of canine vector-borne pathogens, including nematodes ranked in the genus Cercopithifilaria. Though being the object of several studies in the last years, information on the distribution of these parasites is still lacking. In this s...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2017.04.007
更新日期:2017-06-01 00:00:00
abstract::Workers at veterinary clinics are exposed to zoonotic pathogens, which, though infrequently, can lead to serious consequences. The aim of the present study was to estimate the seroprevalence for rickettsial pathogens in veterinary clinic personnel in Ciudad Juárez, Chihuahua, Mexico. Voluntary participants included 10...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2018.10.012
更新日期:2019-02-01 00:00:00
abstract::Theileria equi and Babesia caballi are tick-borne protozoan parasites that can cause anemia in horses. In the Philippines, serological detection of these parasites has only been reported in the Northern area (Luzon). In this study, 105 horses from Cebu and Bohol, Philippines were tested using peripheral blood smear ex...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2018.04.010
更新日期:2018-07-01 00:00:00
abstract::Rickettsial pathogens cause diseases that vary in severity and clinical presentation. Rickettsia species transmitted by ticks are mostly classified within the spotted fever group of rickettsiae (SFGR) and are often associated with febrile diseases. Preliminary studies have detected three human-pathogenic SFGR from tic...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2020.101470
更新日期:2020-09-01 00:00:00
abstract::North Asian tick-typhus (NATT), also known as Siberian tick typhus, is the main tick-borne rickettsiosis in Siberia, Russia. Recently, a fatal infection in a four-year-old girl with typical tick-borne rickettsiosis symptoms (fever, rash, eschar at the site of the tick bite, myalgia) and meningeal syndrome was register...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2019.101278
更新日期:2019-10-01 00:00:00
abstract::Due to the ongoing expansion of Ixodes scapularis (blacklegged tick) throughout the northeastern and midwestern United States, there is need to identify the role wildlife hosts play in the establishment and maintenance of tick populations. To quantify and synthesize the patterns of I. scapularis and Borrelia burgdorfe...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ttbdis.2018.04.006
更新日期:2018-07-01 00:00:00
abstract::The human pathogens Borrelia afzelii, which causes Lyme borreliosis and B. miyamotoi, which causes relapsing fever, both circulate between Ixodes ricinus ticks and rodents. The spatiotemporal dynamics in the prevalence of these pathogens have not yet been fully elucidated, but probably depend on the spatiotemporal pop...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2017.08.008
更新日期:2018-02-01 00:00:00
abstract::Tick-borne diseases have a complex epidemiology that depends on different ecological communities, associating several species of vertebrate hosts, vectors and pathogens. While most studies in Europe are focused on Ixodes ricinus, other Ixodes species may also be involved in the transmission or maintenance of pathogens...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2020.101625
更新日期:2021-03-01 00:00:00
abstract::With the aim of finding quantitative phenotypic traits that can be used to discriminate the levels of resistance/susceptibility to Babesia bovis, we estimated the repeatability and correlation between the level of infection, determined by the number of copies of a fragment of the gene that encodes cytochrome B (NC mt-...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2016.11.008
更新日期:2017-03-01 00:00:00
abstract::Livestock and their ectoparasites are involved in the epidemiology of several zoonotic diseases. Studies regarding the molecular detection of infectious agents in ticks from Northwestern Algeria are scarce. Thus, the presence of spotted fever group Rickettsia spp., Anaplasmataceae microorganisms and Coxiella burnetii ...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2019.04.018
更新日期:2019-06-01 00:00:00
abstract::Ehrlichiosis is a tick-borne bacterial disease caused by pathogens of the Ehrlichia genus. Although human ehrlichiosis has not been reported in Japan, Ehrlichia spp., which are closely related to Ehrlichia chaffeensis, were detected in several species of ixodid ticks. In this study, the presence of Ehrlichia spp. in t...
journal_title:Ticks and tick-borne diseases
pub_type: 杂志文章
doi:10.1016/j.ttbdis.2018.11.010
更新日期:2019-02-01 00:00:00