The expression of N-methyl-D-aspartate-receptor-mediated component during epileptiform synaptic activity in hippocampus.

abstract：BACKGROUND AND PURPOSE:Catechol-O-methyltransferase (COMT) inhibitors are used in Parkinson's disease in which pain is an important symptom. COMT polymorphisms modulate pain and opioid analgesia in humans. In rats, COMT inhibitors have been shown to be pro-nociceptive in acute pain models, but also to attenuate allodyn...

journal_title：British journal of pharmacology

authors： Kambur O,Talka R,Ansah OB,Kontinen VK,Pertovaara A,Kalso E,Männistö PT

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pulmonary arterial hypertension (PAH) is characterized by enhanced pulmonary vascular resistance, right ventricular hypertrophy and increased right ventricular systolic pressure. Here, we investigated the effects of a N-acylhydrazone derivative, 3,4-dimethoxyphenyl-N-methyl-benzoylhydrazide (LASS...

journal_title：British journal of pharmacology

authors： Alencar AK,Pereira SL,Montagnoli TL,Maia RC,Kümmerle AE,Landgraf SS,Caruso-Neves C,Ferraz EB,Tesch R,Nascimento JH,de Sant'Anna CM,Fraga CA,Barreiro EJ,Sudo RT,Zapata-Sudo G

更新日期：2013-07-01 00:00:00

abstract：:1 The fate of (15S)-15-methyl prostaglandin E(2) methyl ester and 16,16-dimethyl prostaglandin E(2) in the pulmonary circulation of rat isolated lungs was compared with that of prostaglandin E(2) by means of bioassay.2 Calculated on the basis of height of response of the assay tissues, the inactivation of prostaglandi...

journal_title：British journal of pharmacology

authors： Bakhle YS,Jancar S,Whittle BJ

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transient receptor potential melastatin 3 (TRPM3) proteins form non-selective but calcium-permeable membrane channels, rapidly activated by extracellular application of the steroid pregnenolone sulphate and the dihydropyridine nifedipine. Our aim was to characterize the steroid binding site by an...

journal_title：British journal of pharmacology

authors： Drews A,Mohr F,Rizun O,Wagner TF,Dembla S,Rudolph S,Lambert S,Konrad M,Philipp SE,Behrendt M,Marchais-Oberwinkler S,Covey DF,Oberwinkler J

更新日期：2014-02-01 00:00:00

abstract：:1. The similarity in molecular structure between the histamine H2-agonist dimaprit (3-dimethylamino-propyl-isothiourea) and the endogenous nitric oxide synthase (NOS) substrate L-arginine prompted us to study the effect of dimaprit and some dimaprit analogues on NOS activity. Dimaprit and some of its analogues were te...

journal_title：British journal of pharmacology

authors： Paquay JB,Hoen PA,Voss HP,Bast A,Timmerman H,Haenen GR

更新日期：1999-05-01 00:00:00

abstract：:1. This study describes attempts to compare prostacyclin (IP-) receptors in human, pig, horse, rabbit and rat platelets and in circular muscle of human, rabbit and dog mesenteric and pig gastroepiploic arteries. Three stable prostacyclin analogues, iloprost, cicaprost and 6a-carba-prostacyclin (6a-carba-PGI2) and a pr...

journal_title：British journal of pharmacology

authors： Armstrong RA,Lawrence RA,Jones RL,Wilson NH,Collier A

更新日期：1989-07-01 00:00:00

abstract：:1 The recently discovered benzodiazepine receptor exists in high concentration in the cerebral cortex. We have, therefore, examined the effects of diazepam and chlordiazepoxide on cortical neurone responses to excitatory and inhibitory amino acids and acetylcholine, in the cortex of rats anaesthetized with urethane.2 ...

journal_title：British journal of pharmacology

authors： Assumpção JA,Bernardi N,Brown J,Stone TW

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We previously demonstrated that chronic hyperinsulinaemia induced by drinking high levels of fructose augments adrenergic nerve-mediated vasoconstriction and suppresses vasodilatation mediated by calcitonin gene-related peptide (CGRP)-containing (CGRPergic) vasodilator nerves. In this study, the ...

journal_title：British journal of pharmacology

authors： Takatori S,Zamami Y,Yabumae N,Hanafusa N,Mio M,Egawa T,Kawasaki H

更新日期：2008-04-01 00:00:00

abstract：:If one drug, B, antagonizes another, A, by producing the opposite physiological effect, the antagonist concentration-effect curves should be affected by the recording system, which limits the range of agonist responses. With pieces of isolated guinea-pig ileum taken from adjacent parts of the same animal, one recorded...

journal_title：British journal of pharmacology

authors： Barlow RB,Bond SM,Grant C,McQueen DS,Yaqoob Z

更新日期：2001-08-01 00:00:00

abstract：:1. Noradrenaline 1 microM induced a contractile response in rat isolated aorta in the presence or in the absence of extracellular Ca2+ with depletion of intracellular Ca2+ stores. Thereafter, during incubation in the presence of Ca2+, an increase in the resting tone was observed. Such a contractile response did not oc...

journal_title：British journal of pharmacology

authors： Noguera MA,D'Ocon MP

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The human prostacyclin receptor (hIP), a G-protein coupled receptor (GPCR) expressed mainly on platelets and vascular smooth muscle cells, plays important protective roles in the cardiovascular system. We hypothesized that significant insights could be gained into the structure and function of th...

journal_title：British journal of pharmacology

authors： Stitham J,Arehart E,Gleim SR,Li N,Douville K,Hwa J

更新日期：2007-10-01 00:00:00

abstract：:1. We have studied the mechanical response of circular strips of the guinea-pig ileum to tachykinins and characterized the receptors involved by means of receptor-selective agonists. 2. The strips responded to both substance P (SP) and neurokinin A (NKA), as well as to [Pro9]-SP sulphone (selective NK1-receptor agonis...

journal_title：British journal of pharmacology

authors： Maggi CA,Patacchini R,Giachetti A,Meli A

更新日期：1990-12-01 00:00:00

abstract：:1. When injected intraperitoneally into mice in doses larger than those used clinically, all the amino derivatives of bisphosphonates (aminoBPs) tested induce a variety of inflammatory reactions such as induction of histidine decarboxylase (HDC, the histamine-forming enzyme), hypertrophy of the spleen, atrophy of the ...

journal_title：British journal of pharmacology

authors： Endo Y,Shibazaki M,Yamaguchi K,Nakamura M,Kosugi H

更新日期：1999-02-01 00:00:00

abstract：:1. Studies in rats suggest that PACAP modulates gastric acid secretion through the release of both histamine and somatostatin. 2. We characterized the effects of exogenous PACAP on gastric acid secretion in urethane-anesthetized mice implanted with a gastric cannula and in conscious 2-h pylorus ligated mice, and deter...

journal_title：British journal of pharmacology

authors： Piqueras L,Taché Y,Martínez V

更新日期：2004-05-01 00:00:00

abstract：:1. Guinea-pig tracheal smooth muscle cells were isolated and maintained in culture for 14-21 days prior to the study of the effect of a selective bradykinin B1 agonist and B2 antagonists upon bradykinin-stimulated phospholipase C and D activities. 2. Bradykinin-stimulated phospholipase C activity was determined by mas...

journal_title：British journal of pharmacology

authors： Pyne S,Pyne NJ

更新日期：1993-09-01 00:00:00

abstract：:Oxidized ATP (oATP) is a Schiff-base-forming reagent that has been used for some years as an antagonist at the P2X7 receptor (P2X7R). Preincubation of mononuclear phagocytes with this inhibitor leads to attenuation of several proinflammatory responses triggered by extracellular ATP as well as a few non-nucleotide agon...

journal_title：British journal of pharmacology

authors： Di Virgilio F

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Leucocyte infiltration is a rate-limiting step in the pathophysiology of acute pancreatitis (AP) although the adhesive mechanisms supporting leucocyte-endothelium interactions in the pancreas remain elusive. The aim of this study was to define the role of lymphocyte function antigen-1 (LFA-1) in ...

journal_title：British journal of pharmacology

authors： Awla D,Abdulla A,Zhang S,Roller J,Menger MD,Regnér S,Thorlacius H

更新日期：2011-05-01 00:00:00

abstract：:1. Exposure of depilated skin of guinea-pig to ultraviolet (u.v.) light for 20 s produces a prolonged inflammatory response.2. The erythaema becomes evident within 15-30 min after the exposure and progressively increases in intensity reaching its maximum by 4-6 hours. The erythaema persists over 24 hours.3. Increase i...

journal_title：British journal of pharmacology

authors： Gupta N,Levy L

更新日期：1973-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pharmacokinetic/pharmacodynamic (PK/PD) models are necessary to relate the degree of drug exposure in vivo to target blockade and pharmacological efficacy. This manuscript describes a murine agonist-induced CXCR3 receptor internalization assay and demonstrates its utility for PK/PD analyses. EXP...

journal_title：British journal of pharmacology

authors： Jopling LA,Watt GF,Fisher S,Birch H,Coggon S,Christie MI

更新日期：2007-12-01 00:00:00

abstract：:1. We have investigated the role of endogenous nitric oxide on renal vascular reactivity in late pregnancy in in situ blood perfused kidneys of alpha-chloralose anaesthetized Wistar-Kyoto rats. Nitric oxide synthesis inhibition was achieved by intravenous administration of NG-nitro-L-arginine or NG-nitro-L-arginine me...

journal_title：British journal of pharmacology

authors： Chu ZM,Beilin LJ

更新日期：1997-09-01 00:00:00

abstract：:1. Caffeine, 0.6-20.0 mM, altered the duration of the action potential recorded from kitten papillary muscles; low concentrations shortened and high concentrations prolonged the action potential.2. Caffeine, 20 mM, prolonged the action potential by delaying the final phase of repolarization.3. Caffeine, 2.0-20.0 mM in...

journal_title：British journal of pharmacology

authors： Clark A,Olson CB

更新日期：1973-01-01 00:00:00

abstract：:1. The effects of fenoverine, an antispasmodic drug, have been studied on the Ca2+ channel currents of isolated cells from rat portal vein and pregnant myometrium by the patch-clamp technique (whole-cell configuration). 2. Fenoverine inhibited both fast and slow Ca2+ channel currents in a concentration-dependent manne...

journal_title：British journal of pharmacology

authors： Mironneau J,Arnaudeau S,Mironneau C

更新日期：1991-09-01 00:00:00

abstract：:1. The effects of pinacidil on noradrenaline-induced tone, smooth muscle membrane potential and 42K- and 86Rb-efflux from isolated mesenteric resistance vessels (internal diameter 200 microns) of the rat have been studied. 2. Pinacidil (0.3-10 microM) produced concentration-dependent suppression of noradrenaline-induc...

journal_title：British journal of pharmacology

authors： Videbaek LM,Aalkjaer C,Mulvany MJ

更新日期：1988-09-01 00:00:00

abstract：:Ever increasing use of engineered carbon nanoparticles in nanopharmacology for selective imaging, sensor or drug delivery systems has increased the potential for blood platelet-nanoparticle interactions. We studied the effects of engineered and combustion-derived carbon nanoparticles on human platelet aggregation in v...

journal_title：British journal of pharmacology

authors： Radomski A,Jurasz P,Alonso-Escolano D,Drews M,Morandi M,Malinski T,Radomski MW

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Insulin resistance is often found to be associated with high blood pressure. We propose that in insulin-resistant hypertension, endothelial dysfunction is the consequence of increased activity of vascular MMP-2. As MMP-2 proteolytically cleaves a number of extracellular matrix proteins, we hypoth...

journal_title：British journal of pharmacology

authors： Nagareddy PR,Rajput PS,Vasudevan H,McClure B,Kumar U,Macleod KM,McNeill JH

更新日期：2012-02-01 00:00:00

abstract：:1. The chemically novel acetohydroxamic acids, BW A4C, BW A137C and BW A797C, are potent inhibitors of the synthesis of leukotriene B4 (LTB4) from arachidonic acid by human leucocyte homogenates: the concentrations required for 50% inhibition (IC50) were 0.1 microM, 0.8 microM and 0.5 microM respectively. Inhibition w...

journal_title：British journal of pharmacology

authors： Tateson JE,Randall RW,Reynolds CH,Jackson WP,Bhattacherjee P,Salmon JA,Garland LG

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The renal sodium-glucose cotransporter 2 (SGLT2) plays an important role in the reuptake of filtered glucose in the proximal tubule and therefore may be an attractive target for the treatment of diabetes mellitus. This study characterizes the pharmacological profile of TS-071 ((1S)-1,5-anhydro-1-...

journal_title：British journal of pharmacology

authors： Yamamoto K,Uchida S,Kitano K,Fukuhara N,Okumura-Kitajima L,Gunji E,Kozakai A,Tomoike H,Kojima N,Asami J,Toyoda H,Arai M,Takahashi T,Takahashi K

更新日期：2011-09-01 00:00:00

abstract：:1. The pharmacological profile of LR-B/081, (methyl 2-[[4-butyl-2-methyl- 6-oxo-5-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1(6H)- pyrimidinyl]methyl]-3-thiophenecarboxylate), a novel antagonist at the angiotensin II (AII) AT1-receptor, was studied in vitro and in vivo. 2. In rabbit aortic strips incubated w...

journal_title：British journal of pharmacology

authors： Cirillo R,Renzetti AR,Cucchi P,Guelfi M,Salimbeni A,Caliari S,Castellucci A,Evangelista S,Subissi A,Giachetti A

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Bortezomib (Velcade®) is a breakthrough treatment for multiple myeloma, significantly improving patient survival. However, its use is limited by painful neuropathy often resulting in dose reduction/cessation of first-line treatment due to lack of treatment. The aim of this study was to characteri...

journal_title：British journal of pharmacology

authors： Duggett NA,Flatters SJL

更新日期：2017-12-01 00:00:00

abstract：:1. The aim of this study was to investigate the relationship between airway reactivity, leukocyte influx and nitric oxide (NO), in conscious guinea-pigs after aerosolized lipopolysaccharide (LPS) exposure. 2. Inhaled histamine (1 mM, 20 s), causing no bronchoconstriction before LPS exposure (30 microg ml(-1), 1 h), ca...

journal_title：British journal of pharmacology

authors： Toward TJ,Broadley KJ

更新日期：2000-09-01 00:00:00