Abstract:
:Individual differences in taste perception may influence appetite, dietary intakes, and subsequently, disease risk. Correlations of DNA methylation patterns at taste transducing genes with BMI and dietary intakes were studied. A nutriepigenomic analysis within the Methyl Epigenome Network Association (MENA) project was conducted in 474 adults. DNA methylation in peripheral white blood cells was analyzed by a microarray approach. KEGG pathway analyses were performed concerning the characterization and discrimination of genes involved in the taste transduction pathway. Adjusted FDR values (p < 0.0001) were used to select those CpGs that showed best correlation with BMI. A total of 29 CpGs at taste transducing genes met the FDR criteria. However, only 12 CpGs remained statistically significant after linear regression analyses adjusted for age and sex. These included cg15743657 (TAS1R2), cg02743674 (TRPM5), cg01790523 (SCN9A), cg15947487 (CALHM1), cg11658986 (ADCY6), cg04149773 (ADCY6), cg02841941 (P2RY1), cg02315111 (P2RX2), cg08273233 (HTR1E), cg14523238 (GABBR2), cg12315353 (GABBR1) and cg05579652 (CACNA1C). Interestingly, most of them were implicated in the sweet taste signaling pathway, except CACNA1C (sour taste). In addition, TAS1R2 methylation at cg15743657 was strongly correlated with total energy (p < 0.0001) and carbohydrate intakes (p < 0.0001). This study suggests that methylation in genes related to sweet taste could be an epigenetic mechanism associated with obesity.
journal_name
Appetitejournal_title
Appetiteauthors
Ramos-Lopez O,Arpón A,Riezu-Boj JI,Milagro FI,Mansego ML,Martinez JA,MENA project.doi
10.1016/j.appet.2017.09.004subject
Has Abstractpub_date
2018-01-01 00:00:00pages
230-239eissn
0195-6663issn
1095-8304pii
S0195-6663(17)30713-4journal_volume
120pub_type
杂志文章相关文献
APPETITE文献大全abstract:OBJECTIVE:Taste sensitivity is one of the most important biological determinants of food choice. Three SNPs of the TAS2R38 gene (rs713598, rs1726866, and rs10246939) give rise to two common haplotypes: PAV and AVI. These haplotypes, as well as an SNP within the CA6 gene (rs2274333) that encodes carbonic anhydrase VI (C...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2017.04.029
更新日期:2017-09-01 00:00:00
abstract::The purpose of this study was to develop a tool for assessing the severity of disturbed eating, use the tool to place disturbed eating behavior severity on a continuum, and to investigate how demographic and psychographic characteristics associated with disturbed eating differ across this continuum. Young adults (n=24...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2012.04.001
更新日期:2012-08-01 00:00:00
abstract::Family food choice is complex with a number of people within the family sharing food choice and preparation responsibilities. Differences in dietary behaviours also exist between various ethnic groups worldwide, and are apparent within multicultural nations such as Australia. This study examined the intergenerational ...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2016.04.036
更新日期:2016-08-01 00:00:00
abstract::Little research has been published concerning the differences between health oriented and ethically oriented vegetarians. The present study compared differences in conviction, nutrition knowledge, dietary restriction, and duration of adherence to vegetarianism between the two groups. Subjects completed an online surve...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2013.02.009
更新日期:2013-06-01 00:00:00
abstract::The aim is to explore changes in food habits after migration, and the resultant present food consumption patterns, as well as the effect of demographic, socio-economic and integration factors on these changes. Analyses were based on data collected through the Oslo Immigrant Health study, from 629 persons 30-60 years o...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2007.09.003
更新日期:2008-03-01 00:00:00
abstract::Appetizers based on different spices/herbs are highly acceptable but evaluation of their functionality needs more attention. The present study, investigated the effects of appetizers on food consumption, weight gain, and leptin levels in male Wistar rats. Three appetizers, namely ginger beverage, ajowan beverage, and ...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2011.04.001
更新日期:2011-08-01 00:00:00
abstract::This research explored how food addiction (FA) and impulsivity (non-planning, motor, and attentional) relate to body mass index (BMI) in a sample of people with type 2 diabetes (t2d). Participants with t2d (N = 334, Mage = 41.0, SDage = 9.5, 66% female, MBMI = 37.6 kg/m(2), SDBMI = 8.0 kg/m(2)) completed an online sur...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2015.07.030
更新日期:2015-12-01 00:00:00
abstract::Family-based treatments show positive relationships between parent and child weight losses. One mechanism for similar parent-child changes may be a common genetic predisposition to respond similarly to a structured weight loss program. We examined whether concordance of the Taq1 A1 allele of the dopamine D2 receptor (...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2010.06.006
更新日期:2010-10-01 00:00:00
abstract::Genetic contribution to individual differences in sour taste perception and preference was investigated in a cohort of young adult Finnish twins (n=328, 21-25 years) including 46 complete monozygotic and 92 dizygotic twin pairs and 52 twin individuals without their co-twin. Responses to sour taste were recorded as ple...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2011.12.020
更新日期:2012-04-01 00:00:00
abstract::The aim of the study was to explore the expectations and experience of actually eating a healthy diet and using this experience to identify barriers to healthy eating and sustainable dietary change. Fifty participants (19-63 yrs) were provided with a healthy diet (i.e. complied with dietary recommendations) for three ...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2013.09.012
更新日期:2013-12-01 00:00:00
abstract:AIM:The aim of the present work was to test the reproducibility of a personalized in-laboratory ad libitum buffet meal in assessing energy and macronutrient intake in obese adolescents. METHODS:Twelve 13.5 ± 1.5 years old obese adolescent girls were asked to complete three identical experimental sessions during which ...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2016.05.028
更新日期:2016-10-01 00:00:00
abstract::This study examined relationships between individual-level socioeconomic position, area-level disadvantage, characteristics of the takeaway food environment, and the purchase of takeaway food. 'Takeaway' is conceptualised as foods or meals that are prepared and purchased outside of the home, and ready for immediate co...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2007.12.002
更新日期:2008-07-01 00:00:00
abstract::Evidence relating to dietary change is contradictory, as some studies document a lack of dietary change while other studies report a degree of success in the implementation and maintenance of long-term dietary change. The present cross-sectional survey aimed to establish the prevalence of dietary change in a community...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2010.08.006
更新日期:2010-12-01 00:00:00
abstract::Children appear to engage in emotional eating (i.e., eating in response to negative and positive emotions), but existing research has predominantly relied on parent-report and child-report, which may not necessarily reflect children's actual emotional eating behaviors. This study examined the effects of happiness and ...
journal_title:Appetite
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.appet.2017.12.021
更新日期:2018-04-01 00:00:00
abstract::Eating behavior style (emotional, restrictive, or external) has been proposed as an explanation for the differences in response to food-related cues between people who overeat and those who do not, and has been also considered a target for the treatment of eating disorders (EDs) characterized by lack of control over e...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2017.07.007
更新日期:2017-10-01 00:00:00
abstract::The sensory characteristics of a product have been shown to interact with actual nutrient content to generate satiety. Separately, cued recall of recent eating has also been shown to reduce food intake. Here we explore for the first time how these two effects interact, with the hypothesis that sensory enhancement of s...
journal_title:Appetite
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.appet.2017.07.018
更新日期:2017-10-01 00:00:00
abstract::Which are the main features associated with taste loss in patients exposed to a wide range of drugs and diseases? In 100 consecutive patients admitted to a ward of internal medicine, we assessed taste complaints, performance status, alcohol and tobacco consumptions, diseases, drugs and laboratory data, measuring the e...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2005.01.001
更新日期:2005-04-01 00:00:00
abstract::Initial acts of self-control have repeatedly been shown to reduce individuals' performance on a consecutive self-control task. In addition, sugar containing drinks have been demonstrated to counteract this so-called ego-depletion effect, both when being ingested and when merely being sensed in the oral cavity. However...
journal_title:Appetite
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.appet.2013.12.020
更新日期:2014-04-01 00:00:00
abstract::In order to assess whether and to what extent extended sensory exposure would modify liking for the sensory characteristics of specific reduced-fat food items, consumers were provided with unlabelled full- or reduced-fat (FF or RF) versions of two foods for home use over 12 weeks. Group 1 (n = 30) received unlabelled ...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/0195-6663(93)90004-4
更新日期:1993-10-01 00:00:00
abstract::The present study investigates the effectiveness of different strategies to improve Willingness to Taste disliked vegetables and the moderating role of Reward Sensitivity. Preschool children (N = 204; age: M = 4.48, SD = 1.01) were randomly allocated to one of four different Willingness to Taste strategies. The findin...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2016.04.017
更新日期:2016-08-01 00:00:00
abstract::In western and westernized societies, large portions of the population live in what are considered to be "obesogenic" environments. Among other things, obesogenic environments are characterized by a high prevalence of external cues that are associated with highly palatable, energy-dense foods. One prominent hypothesis...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2015.05.018
更新日期:2015-10-01 00:00:00
abstract::The nutrition transition has created an obesogenic environment resulting in a growing obesity pandemic. An optimal foraging approach provides cost/benefit models of cognitive, behavioral and physiological strategies that illuminate the causes of caloric surfeit and consequent obesity in current environments of abundan...
journal_title:Appetite
pub_type: 杂志文章,评审
doi:10.1016/j.appet.2006.02.011
更新日期:2006-07-01 00:00:00
abstract::In rats on a stringent deprivation schedule and at reduced body weight, an intragastric load of liquid diet that equals or exceeds normal meal size has no effect at all on subsequent sham feeding of milk diet or of glucose. Removing the acute deprivation period and reversing, or preventing, severe weight reduction has...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1006/appe.1993.1018
更新日期:1993-06-01 00:00:00
abstract::Our diet is believed to be overly rich in sodium, and it is commonly believed that sodium intake increases drinking. Hence the concern of a possible contribution of dietary sodium to beverage intake which in turn may contribute to obesity and ill health. Here we examine whether voluntary, acute intake of a sodium load...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2014.11.014
更新日期:2015-02-01 00:00:00
abstract::It has been suggested that the observation of a model consuming a food (CS) and facially expressing either to like or to dislike (US') the food, may be a sufficient condition to bring about a change in the valence of the food for the observer. Unfortunately, up to now this hypothesis has not been investigated in a str...
journal_title:Appetite
pub_type: 临床试验,杂志文章
doi:10.1006/appe.1996.0049
更新日期:1996-12-01 00:00:00
abstract::This paper explores the meaning of the Mexican dish tacos for Swedish consumers. As such, this study examines the relationship between ethnic food and food culture in light of contemporary changing food rituals. The results reveal that the Swedish food ritual of Friday dinner can be enacted through eating tacos. Frida...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2012.02.010
更新日期:2012-06-01 00:00:00
abstract::Losing weight is a goal for many people, but it is hard to pursue. However, dieting cues in the environment hold promise for improving individuals' eating behavior. For example, exposure to thin, human-like sculptures by the artist Alberto Giacometti has been found to promote healthy snack choices at a vending machine...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2016.11.037
更新日期:2017-03-01 00:00:00
abstract:PURPOSE AND AIM:Sugar-sweetened beverages (SSBs) provide little nutritional value and are associated with an increased risk of diet-related diseases. Despite this, SSB consumption is high globally. One emerging strategy aimed at reducing SSB consumption involves the use of front-of-pack (FOP) labels that clearly identi...
journal_title:Appetite
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.appet.2018.05.149
更新日期:2018-09-01 00:00:00
abstract::In order to see whether weanling normophagic rats with hypothalamic obesity (VMNL rats) become hyperphagic and more obese than when fed lab chow, and to see in addition whether there is a possible sex difference in whatever response is found, male and female VMNL rats were fed lab chow for 14 days after lesion product...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/s0195-6663(86)80007-1
更新日期:1986-12-01 00:00:00
abstract::Scholars have documented multiple influences on family food practices. This article examines an overlooked contributor to family diet: fathers. Using 109 in-depth interviews with middle and upper-middle class mothers, adolescents, and fathers in the United States, I show how fathers can undermine mothers' efforts to p...
journal_title:Appetite
pub_type: 杂志文章
doi:10.1016/j.appet.2017.06.013
更新日期:2017-10-01 00:00:00