Abstract：
:Parents frequently bring their children to the Emergency Department (ED) because of the fever without apparent source (FWAS). To avoid possible complications, it is important to recognize serious bacterial infection (SBI) as early as possible. Various tests, including different clinical scores and scales, are used in the laboratory evaluation of patients. However, it is still impossible to predict the presence of SBI with complete certainty. Galetto-Lacour et al. developed and validated a risk index score, named Lab-score. Lab-score is based on the three predictive variables independently associated with SBI: procalcitonin (PCT), C-reactive protein (CRP), and urinary dipstick. The objective of this study was to assess the performance of the Lab-score in predicting SBI in well-appearing infants ≤ 180 days of age with FWAS, who presented to ED and were hospitalized with suspicion of having SBI. Based on this study findings, white blood cells count (WBC), CRP, PCT, and lab-score ≥ 3 were confirmed as useful biomarkers for differentiation between SBI and non-SBI. Also, receiver operating characteristic curve (ROC) analysis confirmed that all of them were useful for differentiation between SBI and non-SBI patients with the highest area under curve (AUC) calculated for the Lab-score. The results of this research confirmed its value, with calculated sensitivity of 67.7% and specificity of 98.6% in prediction of SBI in infants aged ≤ 180 days. Its value was even better in infants aged ≤ 90 days with sensitivity of 75% and specificity of 97.7%. In conclusion, we demonstrated the high value of lab-score in detecting SBI in infants under 6 months of age with FWAS.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Markic J,Kovacevic T,Krzelj V,Bosnjak N,Sapunar Adoi
10.1007/s00508-015-0831-6subject
Has Abstractpub_date
2015-12-01 00:00:00pages
942-7issue
23-24eissn
0043-5325issn
1613-7671pii
10.1007/s00508-015-0831-6journal_volume
127pub_type
杂志文章abstract：:Evidence demonstrates that medical diabetes treatment has to be accompanied by lifestyle modifications. Structured nutrition interventions and increased physical activity will help patients to normalise, respectively maintain their body weight.The main target of a medical nutrition therapy aims at achieving normal or ...
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journal_title：Wiener klinische Wochenschrift
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doi：
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journal_title：Wiener klinische Wochenschrift
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更新日期：1995-01-01 00:00:00
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journal_title：Wiener klinische Wochenschrift
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