Abstract：
:Individuals with a genetic predisposition to Crohn's disease develop aberrant immune responses to environmental triggers. The gastrointestinal microbiota is increasingly recognized to play an important role in the development of Crohn's disease. Decrease in global gut microbial diversity and specific bacterial alterations have been implicated in Crohn's disease. Advances in sequencing techniques and bioinformatics and correlation with host genetics continue to improve insight into the structure and function of the microbial community and interactions with the host immune system. This article summarizes the existing literature on the role of the gut microbiome and its manipulation in the development and management of Crohn's disease.
journal_name
Gastroenterol Clin North Amjournal_title
Gastroenterology clinics of North Americaauthors
Khanna S,Raffals LEdoi
10.1016/j.gtc.2017.05.004subject
Has Abstractpub_date
2017-09-01 00:00:00pages
481-492issue
3eissn
0889-8553issn
1558-1942pii
S0889-8553(17)30058-4journal_volume
46pub_type
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