Abstract:
:In the present study, the protective potential of Saccharomyces cerevisiae strain UFMG A-905 was evaluated in a murine model of acute ulcerative colitis (UC). Six groups of Balb/c mice were used: not treated with yeast and not challenged with dextran sulphate sodium (DSS) (control); treated with S. cerevisiae UFMG A-905 (905); treated with the non-probiotic S. cerevisiae W303 (W303); challenged with DSS (DSS); treated with S. cerevisiae UFMG A-905 and challenged with DSS (905 + DSS); and treated with S. cerevisiae W303 and challenged with DSS (W303 + DSS). Seven days after induction of UC, mice were euthanised to remove colon for enzymatic, immunological, and histopathological analysis. In vivo intestinal permeability was also evaluated. An improvement of clinical manifestations of experimental UC was observed only in mice of the 905 + DSS group when compared to animals from DSS and W303 + DSS groups. This observation was confirmed by histological and morphometrical data and determination of myeloperoxidase and eosinophil peroxidase activities, intestinal permeability and some pro-inflammatory cytokines. S. cerevisiae UFMG A-905 showed to be a potential alternative treatment for UC when used in an experimental animal model of the disease.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Tiago FC,Porto BA,Ribeiro NS,Moreira LM,Arantes RM,Vieira AT,Teixeira MM,Generoso SV,Nascimento VN,Martins FS,Nicoli JRdoi
10.3920/BM2015.0018subject
Has Abstractpub_date
2015-01-01 00:00:00pages
807-15issue
6eissn
1876-2883issn
1876-2891journal_volume
6pub_type
杂志文章abstract::Vaginal lactobacilli offer protection against microbiota imbalance and genitourinary tract infections. We compared vaginal lactobacilli in 50 Estonian women of child-bearing age applying culture-based methods, quantitative PCR and next-generation sequencing (NGS). The culture-based methods found three different lactob...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0154
更新日期:2015-01-01 00:00:00
abstract::Ulcerative colitis is a type of chronic inflammation present in the intestines for which the aetiology is not yet clear. The current therapies for ulcerative colitis cannot be considered to be long-term management strategies due to their significant side effects. Therefore, it is essential to identify an alternative t...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0035
更新日期:2018-09-18 00:00:00
abstract::Alterations of the gut microbiota and mucosal barrier are linked with metabolic diseases. Our aim was to investigate the potential benefit of the potential probiotic Bifidobacterium animalis ssp. lactis 420 in reducing high-fat diet-induced body weight gain and diabetes in mice. In the obesity model, C57Bl/6J mice wer...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0014
更新日期:2014-12-01 00:00:00
abstract::The current leading view is that functionality and not phylotype is the most important determinant for the services provided by the gut microbiota. Here we present an alternative opinion, advocating the importance of phylotype in addition to function. We believe the literature is misled by technical artifacts in defin...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0016
更新日期:2013-09-01 00:00:00
abstract::Evidence suggests that the gut microbiota might play an important role in fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS). Our goal is to systematically review the reported effect of probiotic treatments in patients diagnosed with FMS or CFS. A systematic review was carried out using 14 databases (PubMe...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0125
更新日期:2018-06-15 00:00:00
abstract::The aim of this study was to evaluate how konjac glucomannan hydrolysates (GMH) could support the healthy re-colonisation of vaginal microflora post infections. A total of 26 female patients (12 controls and 14 treatments) aged 18 to 25 suffering from vaginal infection were recruited for this study. Patients were assi...
journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
doi:10.3920/BM2011.0021
更新日期:2012-03-01 00:00:00
abstract::There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and orga...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章
doi:10.3920/BM2016.0170
更新日期:2017-08-24 00:00:00
abstract::There is growing interest in the use of probiotic lactic acid bacteria (LAB) for prevention of hypercholesterolaemia. This study assessed the cholesterol lowering ability of Pediococcus acidilactici LAB4 and Lactobacillus plantarum LAB12 in growth media. Both LAB yielded >98% (39.2 μg/ml) cholesterol lowering in growt...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2016.0048
更新日期:2017-02-07 00:00:00
abstract::Gut microbiota affects the host's metabolism, and it is suggested that there are differences in gut microbiota composition between patients with type 2 diabetes and healthy individuals. Additionally, dysbiosis may increase the concentration of lipopolysaccharides (LPS), causing metabolic endotoxemia, which induces imp...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2016.0230
更新日期:2017-10-13 00:00:00
abstract::Clinical studies have shown that probiotics positively affect oral health by decreasing gum bleeding and/or reducing salivary counts of certain oral pathogens. Our aim was to investigate the inhibitory effect of six probiotic lactobacilli against opportunistic oral Candida species. Sugar utilisation by both lactobacil...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0054
更新日期:2015-01-01 00:00:00
abstract::Previously, we demonstrated that Propionibacterium acnes, a human skin commensal bacterium, ferments glycerol into short-chain fatty acids, including propionic acid. Propionic acid suppressed the growth of Staphylococcus aureus USA300, a community-acquired methicillin-resistant bacterium, in vitro and in vivo. In this...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0031
更新日期:2014-06-01 00:00:00
abstract::Nutritional intervention studies, like those with pre- and probiotics, are often hampered by low effect sizes, reducing the power to demonstrate potential efficacy. Here, we perform computer simulations of a hypothetical clinical trial using such an intervention in order to elucidate determining factors that can be in...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2020.0044
更新日期:2020-10-12 00:00:00
abstract::Strain specific properties of probiotics in providing supportive health effects in the immune system and the gastrointestinal tract have been widely investigated in vivo and in vitro. However, the underlying responsible mechanism is poorly described. By unravelling the probiotic-induced responses in a complex network ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2011.0052
更新日期:2012-06-01 00:00:00
abstract::The present study investigated some in vitro properties for probiotic use of four strains of bifidobacteria isolated from faeces of healthy children (Bifidobacterium longum 51A, Bifidobacterium breve 1101A, Bifidobacterium pseudolongum 1191A and Bifidobacterium bifidum 1622A). In vitro tests were carried out to compar...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0052
更新日期:2013-06-01 00:00:00
abstract::A basic requirement for the prediction of the potential use of lactic acid bacteria (LAB) in the dairy industry is the identification of specific genes involved in flavour-forming pathways. The probiotic Lactobacillus delbrueckii UFV H2b20 was submitted to a genetic characterisation and phylogenetic analysis of genes ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2011.0025
更新日期:2011-09-01 00:00:00
abstract::The gut is hypothesised to play an important role in the development and progression of sepsis. It is however unknown whether the gut microbiome and the gut barrier function is already altered early in sepsis development and whether it is possible to modulate the microbiome in early sepsis. Therefore, a randomised, do...
journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
doi:10.3920/BM2018.0067
更新日期:2019-04-19 00:00:00
abstract::Dysbiosis may contribute to constipation and its symptoms, therefore probiotic administration could improve significantly gut health and functions. The aim of the study was to investigate the effects of a long-lasting administration of Lactobacillus reuteri DSM 17938 (LR DSM 17938) on symptoms and quality of life (QoL...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2017.0049
更新日期:2018-01-29 00:00:00
abstract::This study aimed to systematically evaluate safety of probiotics and synbiotics in immune compromised adults (≥18 years). Safety was analysed using the Common Terminology Clinical Adverse Events (CTCAE version 4.0) classification, thereby providing an update on previous reports using the most recent available clinical...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0079
更新日期:2015-03-01 00:00:00
abstract::Obesity is highly correlated with the dysbiosis of intestinal microbiota, and bifidobacteria are one of the soft targets of this metabolic syndrome. The aim of this study is to evaluate the efficacy of Bifidobacterium sp. MKK4 and rice-based fermented foods on physical, haematological, gut microbiota and lypogenic-lyp...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0056
更新日期:2018-04-25 00:00:00
abstract::We previously reported that dietary heat-killed Lactobacillus brevis SBC8803 affects sleep rhythms in mice. The present study evaluated the effect of consumption of heat-killed SBC8803 on sleep architecture in humans. A non-randomised, placebo-controlled, double blind, and crossover pilot study was conducted using vol...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章
doi:10.3920/BM2015.0118
更新日期:2016-09-01 00:00:00
abstract::Lactobacillus paracasei K5 is a lactic acid bacteria (LAB) strain, isolated recently from feta-type cheese. Its probiotic potential has been demonstrated in a series of established in vitro tests. Moreover, incorporation of L. paracasei K5 as starter culture offered organoleptic and technological advantages to novel f...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0183
更新日期:2018-12-07 00:00:00
abstract::The intestinal microbiota forms a complex ecosystem that is in close contact with its host and has an important impact on health. An increasing number of disorders are associated with disturbances in this ecosystem. Also patients suffering from irritable bowel syndrome (IBS) show an altered composition of their gut mi...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2013.0033
更新日期:2014-09-01 00:00:00
abstract::The mechanism of neurodegeneration in Parkinson's disease (PD) remains unknown but it has been hypothesised that the intestinal tract could be an initiating and contributing factor to the neurodegenerative processes. In PD patients as well as in animal models for PD, alpha-synuclein-positive enteric neurons in the col...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0202
更新日期:2018-09-18 00:00:00
abstract::Bacterial vaginosis (BV) is characterised by a depletion of lactobacilli in favour of an overgrowth of anaerobic bacteria. It is associated with increased risk for urogenital infections and abortion. In this study we assessed the effect of a yoghurt drink containing Lactobacillus strains on BV. The strains had been is...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2017.0018
更新日期:2018-01-29 00:00:00
abstract::Thermotolerant Campylobacter spp., specifically Campylobacter jejuni and Campylobacter coli, are the most common bacterial causes of human gastroenteritis in developed countries. Consumption of improperly prepared poultry products and cross contamination are among the main causes of human campylobacteriosis. The aim o...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0021
更新日期:2012-12-01 00:00:00
abstract::Gut bacteria influence host anatomy and physiology. It has been proposed that bacterial metabolites including polyamines are responsible for intestinal maturation and mucosal growth. We have hypothesised that bacterially produced polyamines act as trophic factors and thereby influence large intestinal crypt depth and ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0047
更新日期:2013-09-01 00:00:00
abstract::The objective of the study was to isolate potential probiotic lactobacilli from Kimere, a pearl millet dough prepared in the Mbeere community of Kenya, East Africa, by fermentation for 18-24 hours. Kimere samples, collected from 11 different homesteads in Mbeere, showed average pH values of 3.63±0.29. Counts of presum...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2010.0019
更新日期:2010-09-01 00:00:00
abstract::Knee osteoarthritis (OA) treatment is challenging due to inefficacy and adverse effects of current medications. Probiotic treatment has been shown to promote bone metabolism, reduce pain and inflammatory responses of age-related musculoskeletal disorders, including OA. We aimed to investigate the effect of probiotic L...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2016.0207
更新日期:2017-10-13 00:00:00
abstract::The establishment of the gut microbiota immediately after birth is a dynamic process that may impact lifelong health. At this important developmental stage in early life, human milk oligosaccharides (HMOs) serve as specific substrates to shape the gut microbiota of the nursling. The well-orchestrated transition is imp...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2020.0005
更新日期:2020-11-16 00:00:00
abstract::The prevalence of obesity is continuously growing and has reached epidemic proportions. It is clear that current methods to combat obesity are not effective enough to reduce the problem. Therefore, further investigation is needed to develop new strategies. Recent research pointed out a potential role of the microbial ...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2011.0020
更新日期:2011-12-01 00:00:00