Abstract:
:Stem cells are considered to be among the principle scientific breakthroughs of the twentieth century for the future of medicine, and considered to be an important weapon to fight against diseases, particularly those that have resisted the efforts of science for a long time. Human dental tissues have limited potentials to regenerate but the discovery of dental stem cells have developed new and surprising scenario in regenerative dentistry. Stem cell treatments are one example of the possibility using adult cells sourced from patients' own bodies' means that it can be expected that in the near future such treatments may become routine at dental practices. The hope is that it will become possible to regenerate bone and dental tissues including the periodontal ligament, dental pulp and enamel, and that the creation of new teeth may also become feasible. In view of this possibility of achieving restoration with regenerative medicine, it can be considered that a new era of dentistry is beginning. Thus the aim of this review is to give dental professionals a brief overview of different stem cells sources and the latest findings and their implications for improving oral health and treating certain conditions of the human mouth and face.
journal_name
World J Stem Cellsjournal_title
World journal of stem cellsauthors
Aly LAdoi
10.4252/wjsc.v7.i7.1047subject
Has Abstractpub_date
2015-08-26 00:00:00pages
1047-53issue
7issn
1948-0210journal_volume
7pub_type
杂志文章,评审abstract::Faecal continence is a complex function involving different organs and systems. Faecal incontinence is a common disorder with different pathogeneses, disabling consequences and high repercussions for quality of life. Current management modalities are not ideal, and the development of new treatments is needed. Since 20...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v10.i7.82
更新日期:2018-07-26 00:00:00
abstract::Autophagy is a highly regulated catabolic process in which superfluous, damaged organelles and other cytoplasmic constituents are delivered to the lysosome for clearance and the generation of macromolecule substrates during basal or stressed conditions. Autophagy is a bimodal process with a context dependent role in t...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v12.i5.303
更新日期:2020-05-26 00:00:00
abstract::Dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B), also known as minibrain-related kinase (MIRK) is one of the best functionally studied members of the DYRK kinase family. DYRKs comprise a family of protein kinases that are emerging modulators of signal transduction pathways, cell proliferation an...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v12.i12.1553
更新日期:2020-12-26 00:00:00
abstract::Mesenchymal stem cells, due to their characteristics are ideal candidates for cellular therapy. Currently, in culture these cells are defined by their adherence to plastic, specific surface antigen expression and multipotent differentiation potential. However, the in vivo identification of mesenchymal stem cells, befo...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v7.i2.470
更新日期:2015-03-26 00:00:00
abstract::Disabling hearing loss is the most common sensorineural disability worldwide. It affects around 466 million people and its incidence is expected to rise to around 900 million people by 2050, according to World Health Organization estimates. Most cases of hearing impairment are due to the degeneration of hair cells (HC...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v12.i6.422
更新日期:2020-06-26 00:00:00
abstract::Current techniques to improve bone regeneration following trauma or tumour resection involve the use of autograft bone or its substitutes supplemented with osteoinductive growth factors and/or osteogenic cells such as mesenchymal stem cells (MSCs). Although MSCs are most commonly grown in media containing fetal calf s...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v8.i2.47
更新日期:2016-02-26 00:00:00
abstract::Cardiovascular diseases (CVDs) continue to represent the number one cause of death and disability in industrialized countries. The most severe form of CVD is acute myocardial infarction (AMI), a devastating disease associated with high mortality and disability. In a substantial proportion of patients who survive AMI, ...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v10.i8.106
更新日期:2018-08-26 00:00:00
abstract::Cancer remains one of the leading causes of mortality and morbidity throughout the world. To a significant extent, current conventional cancer therapies are symptomatic and passive in nature. The major obstacle to the development of effective cancer therapy is believed to be the absence of sufficient specificity. Sinc...
journal_title:World journal of stem cells
pub_type: 杂志文章
doi:10.4252/wjsc.v3.i11.96
更新日期:2011-11-26 00:00:00
abstract::Dysphagia, defined as difficulty swallowing, is a common symptom negatively impacting millions of adults annually. Estimated prevalence ranges from 14 to 33 percent in those over age 65 to over 70 percent in a nursing home setting. The elderly, those with neurodegenerative diseases, head and neck cancer patients, and ...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v12.i9.1001
更新日期:2020-09-26 00:00:00
abstract:AIM:To improve hepatic differentiation of human mesenchymal stem cell (MSC) using insulin growth factor 1 (IGF-I), which has important role in liver development, hepatocyte differentiation and function. METHODS:Bone marrow of healthy donors was aspirated from the iliac crest. The adherent cells expanded rapidly and we...
journal_title:World journal of stem cells
pub_type: 杂志文章
doi:10.4252/wjsc.v3.i12.113
更新日期:2011-12-26 00:00:00
abstract::Stress urinary incontinence (SUI), as an isolated symptom, is not a life threatening condition. However, the fear of unexpected urine leakage contributes to a significant decline in quality of life parameters for afflicted patients. Compared to other forms of incontinence, SUI cannot be easily treated with pharmacothe...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v5.i4.112
更新日期:2013-10-26 00:00:00
abstract::The use of skin flaps in reconstructive surgery is the first-line surgical treatment for the reconstruction of skin defects and is essentially considered the starting point of plastic surgery. Despite their excellent usability, their application includes general surgical risks or possible complications, the primary an...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v8.i3.101
更新日期:2016-03-26 00:00:00
abstract::Parkinson's disease (PD) is an age-related neurodegenerative disease caused by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. As DA neurons degenerate, PD patients gradually lose their ability of movement. To date no effective therapies are available for the treatment of PD and its pathogen...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v11.i9.634
更新日期:2019-09-26 00:00:00
abstract::The recent discovery of cancer cell plasticity, i.e. their ability to reprogram into cancer stem cells (CSCs) either naturally or under chemotherapy and/or radiotherapy, has changed, once again, the way we consider cancer treatment. If cancer stemness is a reversible epigenetic state rather than a genetic identity, op...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v11.i11.920
更新日期:2019-11-26 00:00:00
abstract:AIM:To study the ability of human adipose-derived mesenchymal stem cells (AMSCs) to survive over the short and long term, their biodistribution and their biosafety in vivo in tumor-prone environments. METHODS:We subcutaneously injected human AMSCs from different human donors into immunodeficient SCID mice over both sh...
journal_title:World journal of stem cells
pub_type: 杂志文章
doi:10.4252/wjsc.v3.i6.53
更新日期:2011-06-26 00:00:00
abstract::The identification of an ideal cell source for tissue regeneration remains a challenge in the stem cell field. The ability of progeny cells to differentiate into other cell types is important for the processes of tissue reconstruction and tissue engineering and has clinical, biochemical or molecular implications. The ...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v7.i10.1202
更新日期:2015-11-26 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease in which patients exhibit gradual loss of memory that impairs their ability to learn or carry out daily tasks. Diagnosis of AD is difficult, particularly in early stages of the disease, and largely consists of cognitive assessments, with only one in f...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v6.i2.239
更新日期:2014-04-26 00:00:00
abstract::Mesenchymal stem cells (MSCs) are a pleiotropic population of cells that are self-renewing and capable of differentiating into canonical cells of the mesenchyme, including adipocytes, chondrocytes, and osteocytes. They employ multi-faceted approaches to maintain bone marrow niche homeostasis and promote wound healing ...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v6.i5.526
更新日期:2014-11-26 00:00:00
abstract::Mesenchymal stem cells (MSCs) are adult stem cells harboring self-renewal and multilineage differentiation potential that are capable of differentiating into osteoblasts, adipocytes, or chondrocytes in vitro, and regulating the bone marrow microenvironment and adipose tissue remodeling in vivo. The process of fate det...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v11.i12.1084
更新日期:2019-12-26 00:00:00
abstract::Obstructive sleep apnea syndrome (OSAS) is a widespread disorder, characterized by recurrent upper airway obstruction during sleep, mostly as a result of complete or partial pharyngeal obstruction. Due to the occurrence of frequent and regular hypoxic events, patients with OSAS are at increased risk of cardiovascular ...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v8.i10.332
更新日期:2016-10-26 00:00:00
abstract::Allogeneic bone marrow transplant is a life-saving procedure for adults and children that have high-risk or relapsed hematological malignancies. Incremental advances in the procedure, as well as expanded sources of donor hematopoietic cell grafts have significantly improved overall rates of success. Yet, the outcomes ...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v6.i4.380
更新日期:2014-09-26 00:00:00
abstract:BACKGROUND:Liver organoids have recently been applied as models for liver disease and drug screening, especially when combined with liver-on-a-chip technologies. Compared to hepatocyte-like cells, primary hepatocytes have high functionality but cannot maintain their function when cultured in vitro. Mesenchymal stem cel...
journal_title:World journal of stem cells
pub_type: 杂志文章
doi:10.4252/wjsc.v12.i10.1184
更新日期:2020-10-26 00:00:00
abstract::Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following to...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v11.i8.506
更新日期:2019-08-26 00:00:00
abstract:AIM:To investigate the potential for early gestation placenta-derived mesenchymal stromal cells (PMSCs) for fetal tissue engineering. METHODS:PMSCs were isolated from early gestation chorionic villus tissue by explant culture. Chorionic villus sampling (CVS)-size tissue samples (mean = 35.93 mg) were used to test the ...
journal_title:World journal of stem cells
pub_type: 杂志文章
doi:10.4252/wjsc.v7.i1.195
更新日期:2015-01-26 00:00:00
abstract::Neural stem cells (NSCs) contribute to ontogeny by producing neurons at the appropriate time and location. Neurogenesis from NSCs is also involved in various biological functions in adults. Thus, NSCs continue to exert their effects throughout the lifespan of the organism. The mechanism regulating the core functional ...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v6.i4.485
更新日期:2014-09-26 00:00:00
abstract::Multipotent mesenchymal stromal cells (MSC), have the potential to differentiate into cells of the mesenchymal lineage and have non-progenitor functions including immunomodulation. The demonstration that MSCs are perivascular cells found in almost all adult tissues raises fascinating perspectives on their role in tiss...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v6.i2.134
更新日期:2014-04-26 00:00:00
abstract:AIM:To development of an improved p38 MAPK inhibitor-based serum-free medium for embryoid body cardiomyocyte differentiation of human pluripotent stem cells. METHODS:Human embryonic stem cells (hESC) differentiated to cardiomyocytes (CM) using a p38 MAPK inhibitor (SB203580) based serum-free medium (SB media). Nutrien...
journal_title:World journal of stem cells
pub_type: 杂志文章
doi:10.4252/wjsc.v5.i3.86
更新日期:2013-07-26 00:00:00
abstract:AIM:To develop an in vitro model based on neural stem cells derived from transgenic animals, to be used in the study of pathological mechanisms of Alzheimer's disease and for testing new molecules. METHODS:Neural stem cells (NSCs) were isolated from the subventricular zone of Wild type (Wt) and Tg2576 mice. Primary an...
journal_title:World journal of stem cells
pub_type: 杂志文章
doi:10.4252/wjsc.v5.i4.229
更新日期:2013-10-26 00:00:00
abstract::Over the last years, stem cell therapy has emerged as an inspiring alternative to restore cardiac function after myocardial infarction. A large body of evidence has been obtained in this field but there is no conclusive data on the efficacy of these treatments. Preclinical studies and early reports in humans have been...
journal_title:World journal of stem cells
pub_type: 杂志文章,评审
doi:10.4252/wjsc.v7.i2.352
更新日期:2015-03-26 00:00:00
abstract::The gingiva, the masticatory portion of the oral mucosa, is excised and discarded frequently during routine dental treatments and following tooth extraction, dental crown lengthening, gingivectomy and periodontal surgeries. Subsequent to excision, healing eventually happens in a short time period after gingival surger...
journal_title:World journal of stem cells
pub_type: 社论
doi:10.4252/wjsc.v10.i9.116
更新日期:2018-09-26 00:00:00