Successful treatment of fungal endophthalmitis using intravitreal caspofungin.

Abstract:

:Fungal endophthalmitis is a rare condition often associated with poor prognosis. We present a case of postoperative acute fungal endophthalmitis caused by the yeast-like fungus Stephanoascus ciferrii (Candida ciferrii). The fungus was resistant to fluconazole, voriconazole, and amphotericin B but susceptible to caspofungin. Because the degree of vitreal penetration of caspofungin after its intravenous administration is unclear, we performed multiple intravitreal injections, first with 50 µg/0.1 ml and then with 250 µg/0.1 ml caspofungin. Despite the recurrence of symptoms, intravitreal injection of caspofungin finally abolished the inflammation and achieved ambulatory vision that persisted until 1 year of follow-up. To our knowledge, this is the first report of S. ciferrii endophthalmitis and its successful treatment with intravitreal caspofungin.

journal_name

Arq Bras Oftalmol

authors

Danielescu C,Cantemir A,Chiselita D

doi

10.5935/0004-2749.20170048

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

196-198

issue

3

eissn

0004-2749

issn

1678-2925

pii

S0004-27492017000300196

journal_volume

80

pub_type

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