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Targeting Eph/ephrin system in cancer therapy.

Abstract：

:It is well established that the Eph/ephrin system plays a central role in the embryonic development, with minor implications in the physiology of the adult. However, it is overexpressed and deregulated in a variety of tumors, with a primary involvement in tumorigenesis, tumor angiogenesis, metastasis development, and cancer stem cell regeneration. Targeting the Eph/ephrin system with biologicals, including antibodies and recombinant proteins, reduces tumor growth in animal models of hematological malignancies, breast, prostate, colon, head and neck cancers and glioblastoma. Currently, some of these biopharmaceutical agents are under investigations in phase I or phase II clinical trials. Peptides and small molecules targeting protein-protein-interaction (PPI) are in the late preclinical phase where they are showing promising activity in models of glioblastoma, ovarian and lung cancer. The present review summarizes the most critical findings proposing the Eph/ephrin signaling system as a new target in molecularly targeted oncology.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Lodola A,Giorgio C,Incerti M,Zanotti I,Tognolini M

doi

10.1016/j.ejmech.2017.07.029

subject

Has Abstract

pub_date

2017-12-15 00:00:00

pages

152-162

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(17)30551-2

journal_volume

142

pub_type

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