Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.

Abstract:

BACKGROUND AND AIM:The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA). PATIENTS AND METHODS:HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time. CONCLUSION:We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Nakanishi R,Post WS,Osawa K,Jayawardena E,Kim M,Sheidaee N,Nezarat N,Rahmani S,Kim N,Hathiramani N,Susarla S,Palella F,Witt M,Blaha MJ,Brown TT,Kingsley L,Haberlen SA,Dailing C,Budoff MJ

doi

10.1097/MCA.0000000000000546

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

23-29

issue

1

eissn

0954-6928

issn

1473-5830

journal_volume

29

pub_type

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