Abstract：
:Traditional chemotherapies, interleukins, phosphorylase inhibitors, and proteasome inhibitors are important therapies available to patients with cutaneous T-cell lymphoma (CTCL). Traditional chemotherapies, both in combination and as single agents, are commonly used in relapsed, refractory CTCLs that behave in an aggressive manner. Interleukins, phosphorylase inhibitors, and proteasome inhibitors are less commonly used but data support a role in patients with more refractory disease.
journal_name
Dermatol Clinjournal_title
Dermatologic clinicsauthors
Chung CG,Poligone Bdoi
10.1016/j.det.2015.05.012subject
Has Abstractpub_date
2015-10-01 00:00:00pages
787-805issue
4eissn
0733-8635issn
1558-0520pii
S0733-8635(15)00057-1journal_volume
33pub_type
杂志文章,评审abstract：:This article discusses ways to recognize and manage lymphomas and pseudolymphomas associated with drug exposure. Over the last 30 years, the classification of pseudolymphomas and lymphomas has undergone significant change, especially following the application of sophisticated immunostaining and gene rearrangement anal...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2007.01.008
更新日期：2007-04-01 00:00:00
abstract：:KS remains a challenge to clinicians and investigators more than a century after its initial description. Debate continues as to the cell of origin, as well as whether or not it is a true cancer. KS appears to be an opportunistic neoplasm, which in its earliest phase retains some features of a benign hyperproliferativ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(05)70424-1
更新日期：1997-01-01 00:00:00
abstract：:Contact dermatitis is a common skin disease caused by contact with irritants or allergens. Irritant contact dermatitis is a result of nonspecific irritant factors, which cause activation of mainly innate immunity, resulting in skin inflammation. Contact hypersensitivity, which manifests itself as allergic contact derm...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2007.06.002
更新日期：2007-10-01 00:00:00
abstract：:With simple, inexpensive therapy, virtually all venous ulcers heal without the need for hospitalization, skin grafting, growth factors, hyperbaric oxygen, or debilitating bed rest. Although the future promises to yield a greater understanding about the nature of these wounds and ways to treat them, one can benefit the...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1993-10-01 00:00:00
abstract：:Laser skin surgery is not without risk and some degree of downtime in most situations. Patient satisfaction is key to the perceived success of the procedure. Therefore, the physician must fully explain all risks, potential complications, and expected morbidity associated with any laser treatment to be performed. Altho...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(03)00054-8
更新日期：2002-01-01 00:00:00
abstract：:Pruritus ani is a common dermatologic complaint that can be frustrating to treat. Effective therapy depends upon recognition of a variety of etiologic factors that may contribute to the symptom. ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1987-10-01 00:00:00
abstract：:Medical spas are the fasting growing segment of the 15-billion dollar spa industry. Although medical spas have been in existence since ancient times to treat a wide variety of ailments such as gout, arthritis, and diabetes, our modern concept of the medical spa combines relaxation with medical rejuvenative procedures....
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2008.03.003
更新日期：2008-07-01 00:00:00
abstract：:The only spiders of real medical importance to humans in the United States are the Loxosceles and Latrodectus species, primarily the brown recluse and the black window, respectively. These spiders bite humans only when trapped or crushed against the skin. Severe brown recluse spider bites produce dermonecrosis within ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1990-04-01 00:00:00
abstract：:Contact dermatitis in the United States poses a significant public health concern. This article provides a definition of contact dermatitis and its associated risk factors. The authors discuss the epidemiology of occupational contact dermatitis including its incidence and prevalence, and describe how estimates are cal...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2011.08.004
更新日期：2012-01-01 00:00:00
abstract：:Hand dermatitis is a common disease of the skin resulting in significantly decreased quality of life. Allergic contact dermatitis is a frequent cause of hand dermatitis. Recent studies have revealed that biocides used as preservatives are frequent allergens affecting the hands. This article reviews common biocides imp...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2009.05.007
更新日期：2009-07-01 00:00:00
abstract：:We have limited the scope of this article to those disorders that have already been successfully diagnosed or excluded in utero. We currently have the potential to diagnose a number of others for which the opportunity has not yet arisen. If a biochemical, morphologic, chromosomal, or DNA alteration is known for a spec...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1987-01-01 00:00:00
abstract：:Although trichoscopy has only recently been introduced in the assessment of hair and scalp disorders, it is already considered an essential diagnostic tool by many experts in the field. This article discusses topics that are often a source of doubt among clinicians, and tips that may help dermatologists better perform...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2018.05.008
更新日期：2018-10-01 00:00:00
abstract：:Occupational contact dermatitis in hairdressers is a common clinical dermatologic problem. Apparently often secondary to irritant contact dermatitis caused by shampooing in Europe, in North America, allergic contact dermatitis related to the chemicals handled, especially oxidation dyes and permanent waving components,...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:The technical advances of the last century changed the understanding of the science of cutaneous physiology and pathology and the role of the dermatologist. The major challenges the international dermatologic community faces today are the lack of a common, logical, and accepted language within the specialty; long-acce...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2007.11.002
更新日期：2008-04-01 00:00:00
abstract：:Stress is an abnormal or extreme adjustment in the physiology of an animal to cope with adverse effects of its environment and management. The adverse effect is designated the stressor. In this article, the authors try to focus on the main types of host factors that can influence stress (genetics, perception) and on t...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(05)70368-5
更新日期：1996-07-01 00:00:00
abstract：:Pharmaceutical manufacturing is one of the most financially lucrative industries in America due, in part, to massive marketing and advertising. The content of many symposia and medical journals as well as physician prescribing decisions seems to be influenced by the promotional efforts of pharmaceutical companies. In ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1993-04-01 00:00:00
abstract：:Rothmund-Thomson syndrome is a rare inherited disorder characterized by poikilodermatous skin changes that appear in infancy. The inheritance is autosomal recessive. Patients exhibit variable features including skeletal abnormalities, juvenile cataracts, and a higher-than-expected incidence of malignancy. This article...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：:Atypical gingivostomatitis is recognized by a combination of clinical findings, a sharply marginated, deep red edematous quality to the attached gingiva, angular cheilitis, and a sore red tongue. Unfortunately, there are no general laboratory tests that are diagnostic of the condition, although biopsy of the gingiva s...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1987-10-01 00:00:00
abstract：:Dermatologists helped to develop the specialty of liposuction surgery and contributed to many of the innovations and instrumentation in this field. Dermatologists were trained side by side with other cosmetic surgeons as the procedure was introduced into the United States. Dermatologists have been important in teachin...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Papulosquamous eruptions are the most frequently seen cutaneous manifestations of human immunodeficiency virus (HIV) infection. Especially common and useful in making a diagnosis of HIV infection are seborrheic dermatitis, xerosis or ichthyosis, and a pruritic or papular eruption. There is some evidence from transgeni...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1991-07-01 00:00:00
abstract：:Photoaggravated skin disorders are diseases that occur without UV radiation but are sometimes or frequently exacerbated by UV radiation. In conditions, such as lupus erythematosus, photoaggravation occurs in a majority of patients, whereas in conditions, such as psoriasis and atopic dermatitis, only a subset of patien...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2014.03.008
更新日期：2014-07-01 00:00:00
abstract：:Epidermolysis bullosa (EB) in Mexico continues to be a rare genodermatosis that is still unknown for most of the health care professionals in the country. The spirit of DebRA MEXICO was born in 1994 when the Mexican health care team started to see patients with the main purpose to provide medical care, genetic counsel...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2010.02.014
更新日期：2010-04-01 00:00:00
abstract：:There are numerous cutaneous findings associated with liver diseases. Although most of these changes are nonspecific and therefore are of limited value in the actual diagnosis of hepatic disease, recognition of the association may be useful for diagnosis and for monitoring the patient's response to treatment. ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1989-07-01 00:00:00
abstract：:In this article, vulvar anatomy and histology are reviewed, and nonneoplastic and neoplastic epithelial disorders are presented. Included are lichen sclerosus, squamous cell hyperplasia, vulvar intraepithelial neoplasia, vulvar Paget's disease, and squamous cell carcinoma. Current terminology, tumor measurements, and ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1992-04-01 00:00:00
abstract：:Dermatologic infections are treated to improve the elderly patient's quality of life and prevent disability and death. Pharmacokinetic changes, social issues, and the risk for adverse effects and drug interactions, however, increase the challenge to achieve successful treatment of those over age 65 as compared with yo...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(03)00112-8
更新日期：2004-01-01 00:00:00
abstract：:There has been a resurgence over the past decade of microlipoinjection. Adipose tissue has proved to be a safe and effective filler substance for subcutaneous defects. More recently, lipocytic dermal augmentation, or autologous collagen, has been used to correct dermal defects. ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1995-04-01 00:00:00
abstract：:The large-scale deployment of low-cost, noninvasive mechanisms of early detection are needed to reduce the melanoma burden. A serial 2-step system could power mass screening efforts serving the uninsured and underinsured as well as the rural and remote US counties where melanoma mortality is doubled for lack of access...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2017.06.005
更新日期：2017-10-01 00:00:00
abstract：:Surgery for skin cancer is a major part of clinical dermatology, and the largest single component of dermatologic surgery practice. In general, residency training in dermatology provides comprehensive training in the theory and practice of skin cancer surgery. Practicing dermatologists are similarly expert in this are...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2016.02.012
更新日期：2016-07-01 00:00:00
abstract：:The sensitizing capacity of double-headed haptens containing the pyrocatechol and alpha-methylene-gamma-butyrolactone groups reveals that only the pyrocatechol end is recognized as a sensitizer. Prior sensitization to the double-headed hapten provides protection against (induces immune tolerance to) further sensitizat...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Normal and malignant pigment cells are known targets for many hormones. Besides alpha-melanocyte-stimulating hormone and the steroidal hormones estrogen, testosterone, and glucocorticoids, factors produced by other epidermal cells can affect melanization and proliferation of pigment cells. Among those factors are the ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1988-04-01 00:00:00
