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[Long-term effects of intensive intervention on changes in lifestyle in patients with hyperfibrinogenaemia and moderate-high cardiovascular risk].

Abstract：

OBJECTIVES:To determine whether the benefit on cardiovascular risk factors (CVRF) persists 5 years after an intensive intervention in lifestyle (LS) that lasted 2 years, in patients with hyperfibrinogenaemia and moderate or high cardiovascular risk. DESIGN:multicentre prospective observational study. LOCATION:13 Primary Care Centres in Barcelona and Baix Llobregat. PARTICIPANTS:A total of 300 patients who completed the EFAP study (146 intervention group, 154 control group). INTERVENTIONS:The EFAP study, conducted on patients with normal cholesterol and elevated fibrinogen showed that lifestyle interventions are effective in reducing CVRF. After the EFAP study, the 2 groups followed the usual controls, and re-assessed after 5 years. MAIN MEASUREMENTS:Age, gender, cardiovascular diseases (CVD) (diabetes, dyslipidaemia, hypertension, obesity), laboratory parameters (fibrinogen, glucose, full blood count, cholesterol, triglycerides), blood pressure, weight, height, body mass index (BMI), tobacco and alcohol use, REGICOR. RESULTS:At 5 years, the intervention group had a lower abdominal circumference (98 and 101cm, respectively, P=.043), a lower weight (76.30 and 75.04kg, respectively, P<.001), and BMI (29.5 and 30.97kg/m2, P=.018). Fibrinogen level was lower in the intervention group (330.33 and 320.27 mg/dl respectively, P < .001), and REGICOR risk was also lower in the intervention group (5.65 and 5.59 respectively, P < .06). CONCLUSION:The benefit of an intensive intervention in LS for 2 years to reduce CVRF persists at 5 years, but decreases its intensity over time. It is recommended to repeat the interventions periodically to maintain the beneficial effect on LS.

journal_name

Aten Primaria

journal_title

Atencion primaria

authors

Illamola Martin L,Rodríguez Cristobal JJ,Alonso-Villaverde C,Salvador-González B,Moral Pelaez I

doi

10.1016/j.aprim.2017.04.004

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

325-331

issue

eissn

0212-6567

issn

1578-1275

pii

S0212-6567(16)30520-0

journal_volume

pub_type

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[Long-term effects of intensive intervention on changes in lifestyle in patients with hyperfibrinogenaemia and moderate-high cardiovascular risk].