Abstract:
BACKGROUND:There is increasing evidence that azithromycin 1 g is driving the emergence of macrolide resistance in Mycoplasma genitalium worldwide. We undertook a meta-analysis of M. genitalium treatment studies using azithromycin 1 g single dose and azithromycin 500 mg on day 1 then 250 mg daily for 4 days (5-day regimen) to determine rates of treatment failure and resistance in both regimens. METHODS:The online databases PubMed and Medline were searched using terms "Mycoplasma genitalium", "macrolide" or "azithromycin" and "resistance" up to April 2016. Studies were eligible if they: used azithromycin 1 g or 5 days, assessed patients for macrolide resistant genetic mutations prior to treatment and patients who failed were again resistance genotyped. Random effects meta-analysis was used to estimate failure and resistance rates. RESULTS:Eight studies were identified totalling 435 patients of whom 82 (18.9%) had received the 5-day regimen. The random effects pooled rate of treatment failure and development of macrolide antimicrobial resistance mutations with azithromycin 1 g was 13.9% (95% CI 7.7% to 20.1%) and 12.0% (7.1% to 16.9%), respectively. Of individuals treated with the 5-day regimen, with no prior doxycycline treatment, fewer (3.7%; 95% CI 0.8% to 10.3%, p=0.012) failed treatment, all of whom developed resistance (p=0.027). CONCLUSION:Azithromycin 1 g is associated with high rates of treatment failure and development of macrolide resistance in M. genitalium infection with no pre-existing macrolide mutations. There is moderate but conflicting evidence that the 5-day regimen may be more effective and less likely to cause resistance.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
Horner P,Ingle SM,Garrett F,Blee K,Kong F,Muir P,Moi Hdoi
10.1136/sextrans-2016-053060subject
Has Abstractpub_date
2018-02-01 00:00:00pages
14-20issue
1eissn
1368-4973issn
1472-3263pii
sextrans-2016-053060journal_volume
94pub_type
杂志文章,meta分析,评审abstract:OBJECTIVE:To describe the impact of a repeating behavioural intervention focused on preventive education and provision of STD testing and treatment services to female sex workers. METHODS:A prospective cohort study of 966 sex workers (first of its kind in China) was conducted in Guangzhou from March 1998 to October 19...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.2.110
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To describe and compare sexual behaviour patterns in 1996 (before the explosion of the HIV epidemic in 2000) and 2006, and the correlates of high-risk sexual behaviour in Estonia. METHODS:Data on selected sexual behaviour characteristics were obtained by interviewing a probability sample of the adult populat...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050506
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Intravaginal practices including vaginal washing have been associated with HIV-1 acquisition. This association may be mediated by mucosal disruption, changes in vaginal flora or genital tract inflammatory responses. Reducing vaginal washing could lower women's risk of HIV-1 acquisition. METHODS:23 HIV-1 ser...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050564
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:In a systematic internet-based Chlamydia Screening Implementation Programme in The Netherlands, all chlamydia-positive participants automatically received a testkit after 6 months to facilitate early detection of repeat infections. The authors describe participation in repeat testing and prevalence and det...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2011-050455
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:To investigate the risk factors for infection and the outcome of pregnancy in women diagnosed with syphilis using a molecular approach. METHODS:Case-control study of pregnant women admitted to a maternity ward, with the cases classified as early or latent maternal syphilis, based on clinical-serological dia...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050552
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Poor knowledge regarding STI and HIV transmission, testing and treatment among men who have sex with men (MSM) may be contributing to their disproportionate burden of STIs. However, factors which predispose MSM to having this low knowledge are less understood. AIM:The aim of this study was to identify facto...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2020-054469
更新日期:2020-10-26 00:00:00
abstract:BACKGROUND:HIV is now well established in the Caribbean, with prevalence in several countries being surpassed only by those of sub-Saharan Africa. Continuing inward migration from the Caribbean and a high incidence of some bacterial STIs among Britain's black Caribbean communities, suggests a considerable potential for...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2003.006163
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:Since 2003, over 2000 cases of lymphogranuloma venereum (LGV) have been diagnosed in the U.K. in men who have sex with men (MSM). Most cases present with proctitis, but there are limited data on how to differentiate clinically between LGV and other pathology. We analysed the clinical presentations of rectal L...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2013-051401
更新日期:2014-06-01 00:00:00
abstract::The first choice treatment for late syphilis is penicillin. Other than doxycycline, which penetrates the CNS, there are few alternatives for the treatment of neurosyphilis. We report a case of successful treatment of symptomatic neurosyphilis with parenteral ceftriaxone. ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.79.5.415
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:To study the validity and performance of a number of rapid indicators for the diagnosis of sexually transmitted infections (STIs) in female prostitutes in Dakar, Senegal; characteristics of these indicators were rapidly obtainable, easy to perform, accurate, useful at district level, and reasonable cost. MET...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:To describe the seroepidemiology of herpes simplex virus (HSV) types 1 and 2 in the general populations of eight European countries to better understand recent reported changes in disease epidemiology. METHODS:Belgium, Bulgaria, Czech Republic, England and Wales, Finland, Germany, Netherlands, and Slovenia ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2003.005850
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:The principal aim of the study was to verify whether HPV infection in healthy women, as determined by HPV DNA detection, was associated with an increased risk of development of cervical lesions. METHODS:Cervical smears collected at enrolment into the prospective study conducted in Prague during 1975-83 were...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.79.3.191
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Identifying predictors that contribute to geographical disparities in sexually transmitted infections (STIs) is necessary. This study assesses the spatial relationship between condom availability to locations of STIs in order to better understand these geographical disparities. OBJECTIVES:We conducted a con...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052144
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:The diagnosis and treatment of Chlamydia trachomatis infection is important in preventing persistent or recurrent infection. Expedited partner therapy (EPT) is the favoured and supported method for STI treatment of the Centers for Disease Control and Prevention when the provider cannot be assured that all re...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2016-052887
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:As the global HIV pandemic enters its fourth decade, countries have collected longer time series of surveillance data, and the AIDS-specific mortality has been substantially reduced by the increasing availability of antiretroviral treatment. A refined model with a greater flexibility to fit longer time serie...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050689
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:The incidence of HIV and STIs increased among men who have sex with men (MSM) visiting our STI clinic in Amsterdam. Interestingly, HIV increased mainly among older (> or =35 years) MSM, whereas infection rates of rectal gonorrhoea increased mainly in younger men. To explore this discrepancy we compared trend...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2003.007997
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:To investigate local cellular immune responses in patients with acute urethritis. METHODS:We have established T cell lines from the urethral exudate and examined their phenotype by flow cytometry. As controls, T cell lines were cultured from first pass urine specimens of asymptomatic healthy individuals. R...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.74.4.279
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Genital warts (condyloma acuminatum) remain one of the most commonly reported sexually transmitted infections (STI) worldwide. Most genital warts are caused by non-oncogenic human papilloma virus. Recurrence is common and many patients receive several rounds of treatment. There are limited data in the litera...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2008.030999
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:Concurrency is suggested as an important factor in sexually transmitted infection transmission and acquisition, though little is known regarding factors that may predict concurrency initiation. We examined the association between perception of a partner's non-monogamy (PPNM) and simultaneous or subsequent co...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052111
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Gonorrhoea is increasing among men who have sex with men (MSM). We aimed to determine whether Listerine, a commercial mouthwash product, has an inhibitory effect against Neisseria gonorrhoeae in a randomised controlled trial (RCT) and an in vitro study, and therefore may be a potentially useful agent for gon...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,随机对照试验
doi:10.1136/sextrans-2016-052753
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To identify prevalence and risks factors for syphilis and HIV among rural female sex workers (FSWs) in Cambodia and to describe differences between rural and urban FSWs. METHODS:Interviews and sera were collected from 114 FSWs and tested for HIV using the Serodia-HIV test and positives confirmed with the enz...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.79.4.e2
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:In countries where STI/HIV prevalence data and behavioural data are scarce UNAIDS second generation HIV surveillance guidelines recommend measuring STI/HIV prevalence and risk behaviours in vulnerable populations but do not recommend conducting these surveys concurrently because of concerns about participati...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.3.187
更新日期:2002-06-01 00:00:00
abstract::Qualitative methods have gained support in health sciences research and have a role to play in STI studies. This article reviews the main techniques used by qualitative researchers, with illustrations taken from the field of STIs. ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sti.78.2.87
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:In the absence of a single nucleic acid amplification test (NAAT) that is both highly specific and sensitive for gonorrhoea, many have put forward the 16S-based assay as a confirmatory test for Neisseria gonorrhoeae. This study was undertaken to evaluate the performance of PCR based on 16S ribosomal gene in ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2009.041418
更新日期:2010-11-01 00:00:00
abstract::In industrialised countries, a rapid epidemic phase of HIV transmission has largely given way to more moderated endemic transmission. The dynamics of endemic transmission may differ substantially from those generating epidemic spread. We hypothesise that three elements play an important role in maintaining endemicity ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sti.2006.017269
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVES:Evidence is mixed as to whether meeting sexual partners online ('internet-partners') is associated with risky sexual behaviour and/or sexually transmitted infection transmission. Accordingly, we sought to estimate the prevalence of reporting various online romantic and sexual activities among Norwegian adole...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052152
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Men are not routinely tested for Trichomonas vaginalis (TV) and Mycoplasma genitalium (MG) in the Netherlands and, therefore, very few studies have looked into their prevalence and/or role in urogenital complaints in the Dutch male population. OBJECTIVE:To describe the age-specific prevalence and disease bu...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052118
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:AIDS is the main driver of young widowhood in southern Africa. METHODS:The demographic characteristics of widows, their reported risk behaviours and the prevalence of HIV were examined by analysing a longitudinal population-based cohort of men and women aged 15-54 years in Manicaland, eastern Zimbabwe. The ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2008.033043
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Little is known about infection rates for human immunodeficiency virus (HIV) and other diseases that can be transmitted sexually in Bangladeshi women who may be at intermediate levels of risk--that is, women who are not commercial sex workers (CSWs) but whose sexual contacts may include men at high risk for ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.77.5.344
更新日期:2001-10-01 00:00:00
abstract::Forces at work are described which encourage professionalisation and a reliance on one on one HIV prevention interventions among gay men. Community involvement is intrinsically linked to epidemic phases; when the threat diminishes, so does the community's ability to sustain community level interventions. The area of s...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.78.suppl_1.i176
更新日期:2002-04-01 00:00:00