Which azithromycin regimen should be used for treating Mycoplasma genitalium? A meta-analysis.

Abstract:

BACKGROUND:There is increasing evidence that azithromycin 1 g is driving the emergence of macrolide resistance in Mycoplasma genitalium worldwide. We undertook a meta-analysis of M. genitalium treatment studies using azithromycin 1 g single dose and azithromycin 500 mg on day 1 then 250 mg daily for 4 days (5-day regimen) to determine rates of treatment failure and resistance in both regimens. METHODS:The online databases PubMed and Medline were searched using terms "Mycoplasma genitalium", "macrolide" or "azithromycin" and "resistance" up to April 2016. Studies were eligible if they: used azithromycin 1 g or 5 days, assessed patients for macrolide resistant genetic mutations prior to treatment and patients who failed were again resistance genotyped. Random effects meta-analysis was used to estimate failure and resistance rates. RESULTS:Eight studies were identified totalling 435 patients of whom 82 (18.9%) had received the 5-day regimen. The random effects pooled rate of treatment failure and development of macrolide antimicrobial resistance mutations with azithromycin 1 g was 13.9% (95% CI 7.7% to 20.1%) and 12.0% (7.1% to 16.9%), respectively. Of individuals treated with the 5-day regimen, with no prior doxycycline treatment, fewer (3.7%; 95% CI 0.8% to 10.3%, p=0.012) failed treatment, all of whom developed resistance (p=0.027). CONCLUSION:Azithromycin 1 g is associated with high rates of treatment failure and development of macrolide resistance in M. genitalium infection with no pre-existing macrolide mutations. There is moderate but conflicting evidence that the 5-day regimen may be more effective and less likely to cause resistance.

journal_name

Sex Transm Infect

authors

Horner P,Ingle SM,Garrett F,Blee K,Kong F,Muir P,Moi H

doi

10.1136/sextrans-2016-053060

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

14-20

issue

1

eissn

1368-4973

issn

1472-3263

pii

sextrans-2016-053060

journal_volume

94

pub_type

杂志文章,meta分析,评审
  • Decreasing STD incidence and increasing condom use among Chinese sex workers following a short term intervention: a prospective cohort study.

    abstract:OBJECTIVE:To describe the impact of a repeating behavioural intervention focused on preventive education and provision of STD testing and treatment services to female sex workers. METHODS:A prospective cohort study of 966 sex workers (first of its kind in China) was conducted in Guangzhou from March 1998 to October 19...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.78.2.110

    authors: Ma S,Dukers NH,van den Hoek A,Yuliang F,Zhiheng C,Jiangting F,Lina Z,Xiuxing Z

    更新日期:2002-04-01 00:00:00

  • Changes in high-risk sexual behaviour among Estonian adults between 1996 and 2006.

    abstract:OBJECTIVE:To describe and compare sexual behaviour patterns in 1996 (before the explosion of the HIV epidemic in 2000) and 2006, and the correlates of high-risk sexual behaviour in Estonia. METHODS:Data on selected sexual behaviour characteristics were obtained by interviewing a probability sample of the adult populat...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2012-050506

    authors: Liivlaid H,Uusküla A

    更新日期:2013-03-01 00:00:00

  • A pilot study of the feasibility of a vaginal washing cessation intervention among Kenyan female sex workers.

    abstract:BACKGROUND:Intravaginal practices including vaginal washing have been associated with HIV-1 acquisition. This association may be mediated by mucosal disruption, changes in vaginal flora or genital tract inflammatory responses. Reducing vaginal washing could lower women's risk of HIV-1 acquisition. METHODS:23 HIV-1 ser...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2012-050564

    authors: Masese L,McClelland RS,Gitau R,Wanje G,Shafi J,Kashonga F,Ndinya-Achola JO,Lester R,Richardson BA,Kurth A

    更新日期:2013-05-01 00:00:00

  • High yield of reinfections by home-based automatic rescreening of Chlamydia positives in a large-scale register-based screening programme and determinants of repeat infections.

    abstract:INTRODUCTION:In a systematic internet-based Chlamydia Screening Implementation Programme in The Netherlands, all chlamydia-positive participants automatically received a testkit after 6 months to facilitate early detection of repeat infections. The authors describe participation in repeat testing and prevalence and det...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2011-050455

    authors: Götz HM,van den Broek IV,Hoebe CJ,Brouwers EE,Pars LL,Fennema JS,Koekenbier RH,van Ravesteijn S,Op de Coul EL,van Bergen J

    更新日期:2013-02-01 00:00:00

  • Risk factors and pregnancy outcomes in women with syphilis diagnosed using a molecular approach.

    abstract:OBJECTIVES:To investigate the risk factors for infection and the outcome of pregnancy in women diagnosed with syphilis using a molecular approach. METHODS:Case-control study of pregnant women admitted to a maternity ward, with the cases classified as early or latent maternal syphilis, based on clinical-serological dia...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2012-050552

    authors: Casal C,Araújo Eda C,Corvelo TC

    更新日期:2013-05-01 00:00:00

  • Factors associated with lower knowledge of HIV and STI transmission, testing and treatment among MSM in Ireland: findings from the MSM Internet Survey Ireland (MISI) 2015.

    abstract:BACKGROUND:Poor knowledge regarding STI and HIV transmission, testing and treatment among men who have sex with men (MSM) may be contributing to their disproportionate burden of STIs. However, factors which predispose MSM to having this low knowledge are less understood. AIM:The aim of this study was to identify facto...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2020-054469

    authors: Carey C,O'Donnell K,Davoren M,Quinlan M,Igoe D,Barrett P

    更新日期:2020-10-26 00:00:00

  • Black Caribbean adults with HIV in England, Wales, and Northern Ireland: an emerging epidemic?

    abstract:BACKGROUND:HIV is now well established in the Caribbean, with prevalence in several countries being surpassed only by those of sub-Saharan Africa. Continuing inward migration from the Caribbean and a high incidence of some bacterial STIs among Britain's black Caribbean communities, suggests a considerable potential for...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2003.006163

    authors: Dougan S,Payne LJ,Brown AE,Fenton KA,Logan L,Evans BG,Gill ON

    更新日期:2004-02-01 00:00:00

  • Clinical predictors of rectal lymphogranuloma venereum infection: results from a multicentre case-control study in the U.K.

    abstract:OBJECTIVE:Since 2003, over 2000 cases of lymphogranuloma venereum (LGV) have been diagnosed in the U.K. in men who have sex with men (MSM). Most cases present with proctitis, but there are limited data on how to differentiate clinically between LGV and other pathology. We analysed the clinical presentations of rectal L...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sextrans-2013-051401

    authors: Pallawela SN,Sullivan AK,Macdonald N,French P,White J,Dean G,Smith A,Winter AJ,Mandalia S,Alexander S,Ison C,Ward H

    更新日期:2014-06-01 00:00:00

  • Treatment of neurosyphilis with ceftriaxone.

    abstract::The first choice treatment for late syphilis is penicillin. Other than doxycycline, which penetrates the CNS, there are few alternatives for the treatment of neurosyphilis. We report a case of successful treatment of symptomatic neurosyphilis with parenteral ceftriaxone. ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.79.5.415

    authors: Shann S,Wilson J

    更新日期:2003-10-01 00:00:00

  • Diagnosis of sexually transmitted infections in female prostitutes in Dakar, Senegal.

    abstract:OBJECTIVE:To study the validity and performance of a number of rapid indicators for the diagnosis of sexually transmitted infections (STIs) in female prostitutes in Dakar, Senegal; characteristics of these indicators were rapidly obtainable, easy to perform, accurate, useful at district level, and reasonable cost. MET...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:

    authors: Ndoye I,Mboup S,De Schryver A,Van Dyck E,Moran J,Samb ND,Sakho ML,Thior I,Wade A,Heymann DL,Meheus A

    更新日期:1998-06-01 00:00:00

  • The seroepidemiology of herpes simplex virus type 1 and 2 in Europe.

    abstract:OBJECTIVES:To describe the seroepidemiology of herpes simplex virus (HSV) types 1 and 2 in the general populations of eight European countries to better understand recent reported changes in disease epidemiology. METHODS:Belgium, Bulgaria, Czech Republic, England and Wales, Finland, Germany, Netherlands, and Slovenia ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2003.005850

    authors: Pebody RG,Andrews N,Brown D,Gopal R,De Melker H,François G,Gatcheva N,Hellenbrand W,Jokinen S,Klavs I,Kojouharova M,Kortbeek T,Kriz B,Prosenc K,Roubalova K,Teocharov P,Thierfelder W,Valle M,Van Damme P,Vranckx R

    更新日期:2004-06-01 00:00:00

  • Prospective study on cervical neoplasia: presence of HPV DNA in cytological smears precedes the development of cervical neoplastic lesions.

    abstract:OBJECTIVES:The principal aim of the study was to verify whether HPV infection in healthy women, as determined by HPV DNA detection, was associated with an increased risk of development of cervical lesions. METHODS:Cervical smears collected at enrolment into the prospective study conducted in Prague during 1975-83 were...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.79.3.191

    authors: Tachezy R,Saláková M,Hamsíková E,Kanka J,Havránková A,Vonka V

    更新日期:2003-06-01 00:00:00

  • Condom deserts: geographical disparities in condom availability and their relationship with rates of sexually transmitted infections.

    abstract:BACKGROUND:Identifying predictors that contribute to geographical disparities in sexually transmitted infections (STIs) is necessary. This study assesses the spatial relationship between condom availability to locations of STIs in order to better understand these geographical disparities. OBJECTIVES:We conducted a con...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052144

    authors: Shacham E,Nelson EJ,Schulte L,Bloomfield M,Murphy R

    更新日期:2016-05-01 00:00:00

  • Impact of expedited partner therapy (EPT) implementation on chlamydia incidence in the USA.

    abstract:OBJECTIVES:The diagnosis and treatment of Chlamydia trachomatis infection is important in preventing persistent or recurrent infection. Expedited partner therapy (EPT) is the favoured and supported method for STI treatment of the Centers for Disease Control and Prevention when the provider cannot be assured that all re...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2016-052887

    authors: Mmeje O,Wallett S,Kolenic G,Bell J

    更新日期:2018-11-01 00:00:00

  • A new infectious disease model for estimating and projecting HIV/AIDS epidemics.

    abstract:OBJECTIVES:As the global HIV pandemic enters its fourth decade, countries have collected longer time series of surveillance data, and the AIDS-specific mortality has been substantially reduced by the increasing availability of antiretroviral treatment. A refined model with a greater flexibility to fit longer time serie...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2012-050689

    authors: Bao L

    更新日期:2012-12-01 00:00:00

  • Increase of sexually transmitted infections, but not HIV, among young homosexual men in Amsterdam: are STIs still reliable markers for HIV transmission?

    abstract:OBJECTIVES:The incidence of HIV and STIs increased among men who have sex with men (MSM) visiting our STI clinic in Amsterdam. Interestingly, HIV increased mainly among older (> or =35 years) MSM, whereas infection rates of rectal gonorrhoea increased mainly in younger men. To explore this discrepancy we compared trend...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2003.007997

    authors: van der Bij AK,Stolte IG,Coutinho RA,Dukers NH

    更新日期:2005-02-01 00:00:00

  • Isolation and characterisation of T lymphocytes from the urethra of patients with acute urethritis.

    abstract:OBJECTIVES:To investigate local cellular immune responses in patients with acute urethritis. METHODS:We have established T cell lines from the urethral exudate and examined their phenotype by flow cytometry. As controls, T cell lines were cultured from first pass urine specimens of asymptomatic healthy individuals. R...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.74.4.279

    authors: Brunst M,Shahmanesh M,Sukthankar A,Pearce JH,Gaston JS

    更新日期:1998-08-01 00:00:00

  • Epidemiology and costs associated with genital warts in Canada.

    abstract:BACKGROUND:Genital warts (condyloma acuminatum) remain one of the most commonly reported sexually transmitted infections (STI) worldwide. Most genital warts are caused by non-oncogenic human papilloma virus. Recurrence is common and many patients receive several rounds of treatment. There are limited data in the litera...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2008.030999

    authors: Marra F,Ogilvie G,Colley L,Kliewer E,Marra CA

    更新日期:2009-04-01 00:00:00

  • Association of perceived partner non-monogamy with prevalent and incident sexual concurrency.

    abstract:OBJECTIVES:Concurrency is suggested as an important factor in sexually transmitted infection transmission and acquisition, though little is known regarding factors that may predict concurrency initiation. We examined the association between perception of a partner's non-monogamy (PPNM) and simultaneous or subsequent co...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052111

    authors: Sanchez DM,Schoenbach VJ,Harvey SM,Warren JT,Adimora AA,Poole C,Leone PA,Agnew CR

    更新日期:2016-06-01 00:00:00

  • Antiseptic mouthwash against pharyngeal Neisseria gonorrhoeae: a randomised controlled trial and an in vitro study.

    abstract:BACKGROUND:Gonorrhoea is increasing among men who have sex with men (MSM). We aimed to determine whether Listerine, a commercial mouthwash product, has an inhibitory effect against Neisseria gonorrhoeae in a randomised controlled trial (RCT) and an in vitro study, and therefore may be a potentially useful agent for gon...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/sextrans-2016-052753

    authors: Chow EP,Howden BP,Walker S,Lee D,Bradshaw CS,Chen MY,Snow A,Cook S,Fehler G,Fairley CK

    更新日期:2017-03-01 00:00:00

  • Rural sex work in Cambodia: work characteristics, risk behaviours, HIV, and syphilis.

    abstract:OBJECTIVE:To identify prevalence and risks factors for syphilis and HIV among rural female sex workers (FSWs) in Cambodia and to describe differences between rural and urban FSWs. METHODS:Interviews and sera were collected from 114 FSWs and tested for HIV using the Serodia-HIV test and positives confirmed with the enz...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.79.4.e2

    authors: Sopheab H,Gorbach PM,Gloyd S,Leng HB

    更新日期:2003-08-01 00:00:00

  • The feasibility of integrated STI prevalence and behaviour surveys in developing countries.

    abstract:BACKGROUND:In countries where STI/HIV prevalence data and behavioural data are scarce UNAIDS second generation HIV surveillance guidelines recommend measuring STI/HIV prevalence and risk behaviours in vulnerable populations but do not recommend conducting these surveys concurrently because of concerns about participati...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.78.3.187

    authors: MacLachlan EW,Baganizi E,Bougoudogo F,Castle S,Mint-Youbba Z,Gorbach P,Parker K,Ryan CA

    更新日期:2002-06-01 00:00:00

  • The application of qualitative research methods to the study of sexually transmitted infections.

    abstract::Qualitative methods have gained support in health sciences research and have a role to play in STI studies. This article reviews the main techniques used by qualitative researchers, with illustrations taken from the field of STIs. ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.78.2.87

    authors: Power R

    更新日期:2002-04-01 00:00:00

  • Diagnostic implications of 16S ribosomal assay for gonorrhoea.

    abstract:OBJECTIVES:In the absence of a single nucleic acid amplification test (NAAT) that is both highly specific and sensitive for gonorrhoea, many have put forward the 16S-based assay as a confirmatory test for Neisseria gonorrhoeae. This study was undertaken to evaluate the performance of PCR based on 16S ribosomal gene in ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2009.041418

    authors: Verma R,Sood S,Bala M,Kapil A,Das BK,Sharma VK,Samantaray JC

    更新日期:2010-11-01 00:00:00

  • Maintenance of endemicity in urban environments: a hypothesis linking risk, network structure and geography.

    abstract::In industrialised countries, a rapid epidemic phase of HIV transmission has largely given way to more moderated endemic transmission. The dynamics of endemic transmission may differ substantially from those generating epidemic spread. We hypothesise that three elements play an important role in maintaining endemicity ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.2006.017269

    authors: Rothenberg R

    更新日期:2007-02-01 00:00:00

  • Meeting sexual partners online: associated sexual behaviour and prevalent chlamydia infection among adolescents in Norway: a cross-sectional study.

    abstract:OBJECTIVES:Evidence is mixed as to whether meeting sexual partners online ('internet-partners') is associated with risky sexual behaviour and/or sexually transmitted infection transmission. Accordingly, we sought to estimate the prevalence of reporting various online romantic and sexual activities among Norwegian adole...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052152

    authors: Gravningen K,Aicken CR,Schirmer H,Mercer CH

    更新日期:2016-03-01 00:00:00

  • Trichomonas vaginalis and Mycoplasma genitalium: age-specific prevalence and disease burden in men attending a sexually transmitted infections clinic in Amsterdam, the Netherlands.

    abstract:BACKGROUND:Men are not routinely tested for Trichomonas vaginalis (TV) and Mycoplasma genitalium (MG) in the Netherlands and, therefore, very few studies have looked into their prevalence and/or role in urogenital complaints in the Dutch male population. OBJECTIVE:To describe the age-specific prevalence and disease bu...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052118

    authors: van der Veer C,van Rooijen MS,Himschoot M,de Vries HJ,Bruisten SM

    更新日期:2016-02-01 00:00:00

  • Role of widows in the heterosexual transmission of HIV in Manicaland, Zimbabwe, 1998-2003.

    abstract:BACKGROUND:AIDS is the main driver of young widowhood in southern Africa. METHODS:The demographic characteristics of widows, their reported risk behaviours and the prevalence of HIV were examined by analysing a longitudinal population-based cohort of men and women aged 15-54 years in Manicaland, eastern Zimbabwe. The ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2008.033043

    authors: Lopman BA,Nyamukapa C,Hallett TB,Mushati P,Spark-du Preez N,Kurwa F,Wambe M,Gregson S

    更新日期:2009-04-01 00:00:00

  • Prevalence of infectious diseases in Bangladeshi women living adjacent to a truck stand: HIV/STD/hepatitis/genital tract infections.

    abstract:BACKGROUND:Little is known about infection rates for human immunodeficiency virus (HIV) and other diseases that can be transmitted sexually in Bangladeshi women who may be at intermediate levels of risk--that is, women who are not commercial sex workers (CSWs) but whose sexual contacts may include men at high risk for ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.77.5.344

    authors: Gibney L,Macaluso M,Kirk K,Hassan MS,Schwebke J,Vermund SH,Choudhury P

    更新日期:2001-10-01 00:00:00

  • From community to clients: the professionalisation of HIV prevention among gay men and its implications for intervention selection.

    abstract::Forces at work are described which encourage professionalisation and a reliance on one on one HIV prevention interventions among gay men. Community involvement is intrinsically linked to epidemic phases; when the threat diminishes, so does the community's ability to sustain community level interventions. The area of s...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.78.suppl_1.i176

    authors: Wohlfeiler D

    更新日期:2002-04-01 00:00:00