Coronary and Basilar Artery Ectasia Are Associated: Results From an Autopsy Case-Control Study.

Abstract:

BACKGROUND AND PURPOSE:Intracranial artery dolichoectasia (IADE) and coronary artery ectasia have been associated with stroke and myocardial infarction, respectively. Only rarely have cases of coexisting IADE and coronary artery ectasia been reported. We investigated this association in a large consecutive autopsy series. METHODS:Sixteen stroke patients with IADE were identified among 381 stroke patients and were matched with 16 stroke patients without IADE. The heart and coronary arteries from all patients were examined after a prespecified protocol. RESULTS:Coronary artery ectasia was observed in 8 of the stroke patients with IADE, and in none of the stroke patients without IADE (P=0.008). The diameters of basilar and right coronary arteries were positively correlated (IADE patients, r=0.51; P=0.003 and coronary artery ectasia patients, P=0.006). CONCLUSIONS:This autopsy study examining the association of coronary artery ectasia and IADE in stroke patients suggests a common pathogenesis.

journal_name

Stroke

journal_title

Stroke

authors

Pico F,Labreuche J,Hauw JJ,Seilhean D,Duyckaerts C,Amarenco P

doi

10.1161/STROKEAHA.115.010797

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

224-7

issue

1

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.115.010797

journal_volume

47

pub_type

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