Abstract：
:The effectiveness of alprazolam in treating symptoms of anxiety and depression in 60 patients undergoing coronary bypass surgery was assessed in a double-blind, placebo-controlled study. The results indicate that alprazolam treatment for anxiety following coronary bypass surgery, particularly symptoms occurring in the immediate postoperative period, can significantly affect patient outcome. Specifically, only modest but statistically significant improvement was observed in the alprazolam-treated groups at 1-month follow-up; however, alprazolam-treated patients were significantly more likely to experience a very rapid anxiolytic effect by postoperative day 8. The implications of this study are discussed with respect to patient management and models for future studies of anxiety in postoperative patient populations.
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Freeman AM 3rd,Fleece L,Folks DG,Sokol RS,Hall KR,Pacifico AD,McGiffin DC,Kirklin JK,Zorn GL,Karp RBsubject
Has Abstractpub_date
1986-02-01 00:00:00pages
39-41issue
1eissn
0271-0749issn
1533-712Xjournal_volume
6pub_type
临床试验,杂志文章,随机对照试验abstract：:Little is known about the association between antidepressant treatment-emergent adverse events and symptom nonremission in major depressive disorder. The objective of the current analysis was to determine whether particular baseline symptoms or treatment-emergent symptoms (adverse events) during the first 2 weeks are ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,多中心研究
doi：10.1097/JCP.0b013e318205e17b
更新日期：2011-02-01 00:00:00
abstract：:Ahead of Print article withdrawn by publisher. ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0b013e31829ab413
更新日期：2013-08-22 00:00:00
abstract：:A double-blind, placebo-controlled trial was performed to determine the efficacy and tolerability of 8 weeks of treatment with risperidone in the management of 48 adolescent and adult patients with Tourette syndrome. Twenty-four patients were randomly assigned to treatment with risperidone in doses of 0.5 to 6.0 mg/da...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-200202000-00006
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:Depression, the leading cause of nonfatal disease burden, has a strong correlation with suicide and affects approximately 7% of the general elderly population. Adverse drug reactions in older patients are particularly important because of reduced drug metabolism, polypharmacy, drug-drug interactions, and dru...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000001059
更新日期：2019-07-01 00:00:00
abstract：:The 2-mg dexamethasone suppression test (DST), performed in a drug-free acute exacerbation phase of illness shortly after admission, differentiated between major depression with psychosis and stringently diagnosed chronic schizophrenia. This has practical significance because effective drug treatment in each diagnosti...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1986-12-01 00:00:00
abstract：:Clinical studies that have evaluated serotonergic medications to reduce alcohol consumption have yielded conflicting results. These studies primarily treated patients with alcohol dependence, excluding those with a current depressive disorder, in an effort to differentiate any medication effects directly on drinking f...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-200104000-00005
更新日期：2001-04-01 00:00:00
abstract：:The study describes prescription patterns of psychotropic medications for patients treated for psychosis in psychiatric hospitals of Uganda. A cross-sectional quantitative survey of age, sex, diagnoses, and psychotropic medication of 682 psychiatric inpatients of the 2 national referral hospitals in Uganda was conduct...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000000166
更新日期：2014-10-01 00:00:00
abstract：:The aim of this study was to estimate the long-term effectiveness of olanzapine as adjunctive therapy in patients with bipolar disorder who exhibited an inadequate response to mood stabilizers. Twenty-three Research Diagnostic Criteria (RDC) patients with bipolar I and II were assessed by means of the Schedule for Aff...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/00004714-200110000-00002
更新日期：2001-10-01 00:00:00
abstract：:Phenomenological, physiological, biochemical, and receptor binding measures are useful as dependent variables in affective disorders research. Abnormalities of these measures can result from up-regulation and supersensitivity of cholinergic systems and disturbances of cholinergic-monoaminergic interaction. These devia...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,评审
doi：
更新日期：1986-04-01 00:00:00
abstract：:This article reports the effects of imipramine on heart rate and blood pressure in panic disorder patients who participated in an 8-week double-blind dosage response treatment protocol. At the end of a placebo baseline, patients were randomly assigned to placebo or one of three weight-adjusted imipramine dosages: low ...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-04-01 00:00:00
abstract：:The pharmacokinetic parameters of clozapine and its two main metabolites, N-desmethylclozapine (norclozapine, active metabolite) and clozapine N-oxide, were evaluated, after oral administration, in 19 patients with chronic schizophrenia. Plasma and red blood cell (RBC) drug concentrations were determined by high-perfo...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/00004714-199812000-00010
更新日期：1998-12-01 00:00:00
abstract：:Consensus guidelines which are applicable in New Zealand and worldwide recommend that the duration of exposure to antipsychotics not exceed 12 weeks, unless justified for mental illnesses like schizophrenia and severe psychotic symptoms which require longer treatment. There has been limited information on time-to-firs...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000000597
更新日期：2016-12-01 00:00:00
abstract：:The efficacy of continuation therapy with tricyclic antidepressants has been established in a number of controlled trials. This study investigated the efficacy of continuation therapy with a relatively new antidepressant, amoxapine, using a double-blind controlled comparison with amitriptyline. Subjects met DSM-III cr...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-10-01 00:00:00
abstract：:This study investigated the effects of antidepressant treatment on platelet activation in depressed patients with ischemic heart disease (IHD). Plasma levels of platelet alpha-granule release products beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were measured in 17 depressed patients with IHD who were treate...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-200004000-00004
更新日期：2000-04-01 00:00:00
abstract：:Therapeutic drug monitoring studies of selective serotonin reuptake inhibitor (SSRI) antidepressants thus far failed to identify a clear concentration-response relationship in major depression. Majority of the previous studies defined clinical response as 50% or greater reduction from baseline in depression rating sca...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0b013e3181730850
更新日期：2008-06-01 00:00:00
abstract：PURPOSE/BACKGROUND:To add to limited evidence on the Abnormal Involuntary Movement Scale (AIMS) as a measure of tardive dyskinesia (TD) in clinical practice settings, the characteristics and correlates of AIMS scores were assessed. METHODS/PROCEDURES:Veterans with schizophrenia/schizoaffective, bipolar, or major depre...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000001229
更新日期：2020-07-01 00:00:00
abstract：:To identify factors associated with anticholinergic abuse in patients taking antipsychotics and anticholinergics and to document the extent of extrapyramidal side effects in anticholinergic abusers, 21 anticholinergic abusers were matched with 21 controls without a history of anticholinergic abuse for diagnosis and an...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:Individual daily dosages of nortriptyline (NT) can be predicted from administration of a 50-mg or 100-mg single test dose, with a determination of the plasma level 24 hours later. Because the 50-mg or 100-mg test dose used in previous studies may cause unmanageable acute side effects in elderly patients, a 25-mg NT te...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1987-10-01 00:00:00
abstract：:The aims of this study were to examine whether pindolol, a serotonin (5-hydroxytryptamine [5-HT])-1A receptor antagonist, and mianserin, a 5-HT2A/C and alpha2-adrenoceptor (alpha2-AR) antagonist, may augment the clinical efficacy of fluoxetine, a selective serotonin reuptake inhibitor, and shorten the latency of onset...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-199904000-00014
更新日期：1999-04-01 00:00:00
abstract：:The effects of daily buprenorphine treatment (4 or 8 mg/day, sublingual) on reports of subjective effects after single intravenous doses of morphine (10 mg), cocaine (30 mg), and saline placebo were studied on an inpatient clinical research ward in 26 men concurrently dependent on opioids and cocaine (DSM-III-R). Late...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-02-01 00:00:00
abstract：:Quetiapine is an atypical antipsychotic that has sedative effects. In this retrospective study, indices of alcohol use were compared for alcohol-dependent subjects who either were (n = 30) or were not (n = 20) treated with quetiapine (25 to 200 mg nightly) for disturbed sleep. Indices examined included total days of a...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/01.jcp.0000138763.23482.2a
更新日期：2004-10-01 00:00:00
abstract：:The pharmacokinetics of drugs with specific binding sites in the brain needs to be evaluated at these sites. In this study, we measured the time course of the selective serotonin reuptake inhibitor fluvoxamine in the human brain based on serotonin transporter (5-HTT) occupancy by positron emission tomography. Consecut...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/01.jcp.0000203201.34323.d3
更新日期：2006-04-01 00:00:00
abstract：:Hypersalivation is a frequent, disturbing, and uncomfortable adverse effect of clozapine therapy that frequently leads to noncompliance. The aim of this study was to examine the efficacy of metoclopramide (dopamine D2 antagonist, antiemetic medication) as an option for management of hypersalivation associated with clo...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/JCP.0000000000000493
更新日期：2016-06-01 00:00:00
abstract：:A case of rhabdomyolysis is described, with onset following three intramuscular injections of loxapine and one injection of benztropine over a 7-hour period. The possible additive effects of intramuscular drug administration and psychotic episode-associated increased muscle membrane permeability are discussed. Because...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：:Molindone hydrochloride, a dihydroindolone neuroleptic, is structurally distinct from other classes of neuroleptics. Molindone exhibits many similarities to other neuroleptics, including dopamine receptor blockade, antipsychotic efficacy, and extrapyramidal side effects. Despite these similarities, molindone also has ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,评审
doi：
更新日期：1989-08-01 00:00:00
abstract：:This article reports results for patients who completed the 16-week maintenance phase of a double-blind clinical trial comparing buprenorphine (N = 43; average dose = 9.0 mg/day sublingually) with methadone (N = 43; average dose = 54 mg/day orally) in the outpatient treatment of opioid dependence. In addition to pharm...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-199602000-00010
更新日期：1996-02-01 00:00:00
abstract：:Alcohol cue-induced brain activation has been studied extensively in alcoholics. However, little is known about the impact of standard treatment protocols on this phenomenon. The current study aimed at investigating the impact of the anticraving substance acamprosate on alcohol cue-related brain activity. Patients und...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0b013e318267b586
更新日期：2012-10-01 00:00:00
abstract：:Olanzapine is an atypical antipsychotic effective in the treatment of schizophrenic patients. After a 2- to 9-day placebo lead-in, 79 inpatients with schizophrenia according to DSM-III-R criteria were placed on an olanzapine dosage of 10 mg/day or 1 mg/day for up to 6 weeks. Blood samples were obtained weekly during t...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1097/00004714-199712000-00006
更新日期：1997-12-01 00:00:00
abstract：:There have been an increased number of recent reports on orgasm-related sexual dysfunction coincident with selective serotonin reuptake inhibitor (SSRI) treatment. In contrast, it has also been reported that SSRIs improve sexual dysfunction. Low doses of clomipramine and paroxetine, potent 5-hydroxytryptamine reuptake...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/00004714-199610000-00006
更新日期：1996-10-01 00:00:00
abstract：:The aim of this study was to investigate whether obsessive-compulsive patients previously treated successfully with clomipramine or fluvoxamine could tolerate reduction of the daily dosage without worsening of the clinical condition. Thirty informed obsessive-compulsive patients, given a diagnosis according to DSM-III...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-199702000-00002
更新日期：1997-02-01 00:00:00
