Persistent organic pollutants in infants and toddlers: Relationship between concentrations in matched plasma and faecal samples.

Abstract:

:Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to POPs. The concentrations of selected POPs were measured in matched plasma and faecal samples collected from 20 infants/toddlers (aged 13±4.8months), including a repeat sample time point for 13 infants (~5months apart). We observed higher rates of POP quantification in faeces (2g dry weight) than in plasma (0.5mL). Among the five chemicals that had quantification frequencies over 50% in both matrices, except for HCB, log concentration in faeces (Cf) and blood (Cb) were correlated (r>0.74, P<0.05) for p.p'-dichlorodiphenyldichloroethylene (p,p'-DDE), 2,3',4,4',5-pentachlorobiphenyl (PCB118), 2,2',3,4,4',5'-pentachlorobiphenyl (PCB138) and 2,2',4,4',5,5'-pentachlorobiphenyl (PCB153). We determined faeces:plasma concentration ratios (Kfb), which can be used to estimate Cb from measurements of Cf for infants/toddlers. For a given chemical, the variation in Kfb across individuals was considerable (CV from 0.46 to 0.70). Between 5% and 50% of this variation was attributed to short-term intra-individual variability between successive faecal samples. This variability could be reduced by pooling faeces samples over several days. Some of the remaining variability was attributed to longer-term intra-individual variability, which was consistent with previously reported observations of a decrease in Kfb over the first year of life. The strong correlations between Cf and Cb demonstrate the promise of using faeces for biomonitoring of these compounds. Future research on the sources of variability in Kfb could improve the precision and utility of this technique.

journal_name

Environ Int

authors

Chen Y,Sjodin A,McLachlan MS,English K,Aylward LL,Toms LL,Varghese J,Sly PD,Mueller JF

doi

10.1016/j.envint.2017.06.019

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

82-88

eissn

0160-4120

issn

1873-6750

pii

S0160-4120(17)30627-X

journal_volume

107

pub_type

杂志文章,随机对照试验
  • Physico-chemical and toxicological characterization of the historic estuarine sediments: a multidisciplinary approach.

    abstract::The accumulation rates, the geochronology of metals and PAH contamination, and the Microtox toxicity are studied in five sediment cores (50 cm length) covering different areas of the Santander Bay, Northern Spain. Chronology given by (210)Pb and (137)Cs reveals significant differences in accumulation rates between sit...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2006.10.005

    authors: Viguri JR,Irabien MJ,Yusta I,Soto J,Gómez J,Rodriguez P,Martinez-Madrid M,Irabien JA,Coz A

    更新日期:2007-05-01 00:00:00

  • Long-term exposure to traffic-related PM(10) and decreased heart rate variability: is the association restricted to subjects taking ACE inhibitors?

    abstract:BACKGROUND:Alterations in heart rate variability (HRV) are a potential link between exposure to traffic-related air pollution and cardiovascular mortality. OBJECTIVES:We investigated whether long-term exposure to traffic-related PM(10) (TPM(10)) is associated with HRV in older subjects and/or in participants taking sp...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2012.06.016

    authors: Adam M,Felber Dietrich D,Schaffner E,Carballo D,Barthélémy JC,Gaspoz JM,Tsai MY,Rapp R,Phuleria HC,Schindler C,Schwartz J,Künzli N,Probst-Hensch NM

    更新日期:2012-11-01 00:00:00

  • A review on organophosphate Ester (OPE) flame retardants and plasticizers in foodstuffs: Levels, distribution, human dietary exposure, and future directions.

    abstract::Given the ongoing studies on the adverse effects of organophosphate ester (OPE) flame retardants and plasticizers on human health, there is an increasing scientific interest in the risk of exposure to OPEs via dietary intake. Using peer-reviewed literature published up to 2018, this review surveyed and compiled the av...

    journal_title:Environment international

    pub_type: 杂志文章,评审

    doi:10.1016/j.envint.2019.03.009

    authors: Li J,Zhao L,Letcher RJ,Zhang Y,Jian K,Zhang J,Su G

    更新日期:2019-06-01 00:00:00

  • Associations between blood volatile organic compounds, and changes in hematologic and biochemical profiles, in a population-based study.

    abstract:OBJECTIVE:To investigate the influence of volatile organic compound (VOC) levels in blood, on hematological and serum biochemical parameters in the Canadian population. METHODS:We tested the association between seven selected VOCs and hematological profiles and serum tests reflecting liver and kidney function and gluc...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2020.106121

    authors: Cakmak S,Cole C,Hebbern C,Andrade J,Dales R

    更新日期:2020-12-01 00:00:00

  • Long- and short-term air pollution exposure and measures of arterial stiffness in the Framingham Heart Study.

    abstract:BACKGROUND:Studies of air pollution exposure and arterial stiffness have reported inconsistent results and large studies employing the reference standard of arterial stiffness, carotid-femoral pulse-wave velocity (CFPWV), have not been conducted. AIM:To study long-term exposure to ambient fine particles (PM2.5), proxi...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2018.08.060

    authors: Ljungman PLS,Li W,Rice MB,Wilker EH,Schwartz J,Gold DR,Koutrakis P,Benjamin EJ,Vasan RS,Mitchell GF,Hamburg NM,Mittleman MA

    更新日期:2018-12-01 00:00:00

  • Market basket study on dietary intake of PCDD/Fs, PCBs, and PBDEs in Finland.

    abstract::We have measured the concentrations of polychlorinated dibenzo-p-dioxins (PCDD/F), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDE) in 10 market baskets consisting of almost 4000 individual food samples representing 228 different food items, and also in the total diet basket. Lower bound con...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2004.03.002

    authors: Kiviranta H,Ovaskainen ML,Vartiainen T

    更新日期:2004-09-01 00:00:00

  • Glucocorticoid and mineralocorticoid receptors and corticosteroid homeostasis are potential targets for endocrine-disrupting chemicals.

    abstract::Endocrine-disrupting chemicals (EDCs) have received significant concern, since they ubiquitously exist in the environment and are able to induce adverse health effects on human and wildlife. Increasing evidence shows that the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR), members of the steroid ...

    journal_title:Environment international

    pub_type: 杂志文章,评审

    doi:10.1016/j.envint.2019.105133

    authors: Zhang J,Yang Y,Liu W,Schlenk D,Liu J

    更新日期:2019-12-01 00:00:00

  • Association between ambient beta particle radioactivity and lower hemoglobin concentrations in a cohort of elderly men.

    abstract::Although ionizing radiation is known to have detrimental effects on red blood cells, the effect of environmental radioactivity associated with ambient particulate matter (PM) is unknown. We hypothesized that exposure to ambient PM-associated beta particle radioactivity (PRβ) would be associated with a lower hemoglobin...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2020.105735

    authors: Vieira CLZ,Garshick E,Alvares D,Schwartz J,Huang S,Vokonas P,Gold DR,Koutrakis P

    更新日期:2020-06-01 00:00:00

  • On-site treatment capacity of membrane distillation powered by waste heat or natural gas for unconventional oil and gas wastewater in the Denver-Julesburg Basin.

    abstract::Leveraging waste heat has been considered to have significant potential for promoting the economic feasibility of wastewater treatment in unconventional oil and gas (UOG) production. However, its availability near well sites has not been fully understood and other energy sources may be also feasible. In this work, we ...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2020.106142

    authors: Robbins CA,Grauberger BM,Garland SD,Carlson KH,Lin S,Bandhauer TM,Tong T

    更新日期:2020-12-01 00:00:00

  • Development of outcome-specific criteria for study evaluation in systematic reviews of epidemiology studies.

    abstract:INTRODUCTION AND OBJECTIVE:Systematic review tools that provide guidance on evaluating epidemiology studies are receiving increasing attention and support because their application facilitates improved quality of the review, consistency across reviewers, and transparency for readers. The U.S. Environmental Protection A...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2019.05.078

    authors: Radke EG,Glenn B,Galizia A,Persad A,Nachman R,Bateson T,Wright JM,Navas-Acien A,Arroyave WD,Puett RC,Harville EW,Pollack AZ,Burns JS,Lynch CD,Sagiv SK,Stein C,Cooper GS

    更新日期:2019-09-01 00:00:00

  • Blood cadmium, mercury, and lead in children: an international comparison of cities in six European countries, and China, Ecuador, and Morocco.

    abstract::Children's blood-lead concentration (B-Pb) is well studied, but little is known about cadmium (B-Cd) and mercury (B-Hg), in particular for central Europe. Such information is necessary for risk assessment and management. Therefore, we here describe and compare B-Pb, B-Cd and B-Hg in children in six European, and three...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2011.12.001

    authors: Hrubá F,Strömberg U,Černá M,Chen C,Harari F,Harari R,Horvat M,Koppová K,Kos A,Krsková A,Krsnik M,Laamech J,Li YF,Löfmark L,Lundh T,Lundström NG,Lyoussi B,Mazej D,Osredkar J,Pawlas K,Pawlas N,Prokopowicz A,Rent

    更新日期:2012-05-01 00:00:00

  • Human health risk assessment of pharmaceuticals in treated wastewater reused for non-potable applications in Sharjah, United Arab Emirates.

    abstract::Pharmaceuticals and personal care products are an integral part of societal health yet their presence in various environmental compartments, including treated wastewaters, has sparked concerns towards possible human and ecological health effects. The current study aims to characterize human health risks posed by ten p...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2018.08.048

    authors: Semerjian L,Shanableh A,Semreen MH,Samarai M

    更新日期:2018-12-01 00:00:00

  • Towards a clean Izmit Bay.

    abstract::The elongated semi-enclosed Bay of Izmit, which receives both domestic and industrial wastes, has been monitored by measuring its physical and biochemical parameters for 2 years, 1994-1995. It is clear that there are two distinct water masses. The upper layer has been occupied by the less saline (22-26 ppt) waters of ...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/s0160-4120(00)00103-3

    authors: Morkoç E,Okay OS,Tolun L,Tüfekçi V,Tüfekçi H,Legoviç T

    更新日期:2001-01-01 00:00:00

  • Distribution and dissipation pathways of nonylphenol polyethoxylates in the Yellow River: Site investigation and lab-scale studies.

    abstract::Spatial distribution of nonylphenol polyethoxylates (NPEOs) and nonylphenol (NP) was investigated in a field study in Lanzhou Reach of the Yellow River. NPEOs and their metabolites were found in the river, with the maximum dissolved concentrations of 6.38 nmol/L for NPEOs, 0.19 nmol/L for nonylphenol ethoxy acetic aci...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2006.06.012

    authors: Wang L,Wu Y,Sun H,Xu J,Dai S

    更新日期:2006-09-01 00:00:00

  • Lessons learnt on biases and uncertainties in personal exposure measurement surveys of radiofrequency electromagnetic fields with exposimeters.

    abstract::Personal exposure measurements of radio frequency electromagnetic fields are important for epidemiological studies and developing prediction models. Minimizing biases and uncertainties and handling spatial and temporal variability are important aspects of these measurements. This paper reviews the lessons learnt from ...

    journal_title:Environment international

    pub_type: 杂志文章,评审

    doi:10.1016/j.envint.2016.06.023

    authors: Bolte JFB

    更新日期:2016-09-01 00:00:00

  • Estimating and projecting the effect of cold waves on mortality in 209 US cities.

    abstract::The frequency, duration, and intensity of cold waves are expected to decrease in the near future under the changing climate. However, there is a lack of understanding on future mortality related to cold waves. The present study conducted a large-scale national projection to estimate future mortality attributable to co...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2016.05.008

    authors: Wang Y,Shi L,Zanobetti A,Schwartz JD

    更新日期:2016-09-01 00:00:00

  • Dietary exposure to polychlorinated biphenyls and risk of myocardial infarction in men - A population-based prospective cohort study.

    abstract:BACKGROUND:Major food contaminants such as polychlorinated biphenyls (PCBs) are proposed to play a role in the etiology of cardiovascular disease (CVD), but to date the impact of PCBs on cardiovascular health need to be explored. METHODS AND RESULTS:We assessed the association between validated food frequency question...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2015.11.020

    authors: Bergkvist C,Berglund M,Glynn A,Julin B,Wolk A,Åkesson A

    更新日期:2016-03-01 00:00:00

  • Lolium perenne as a biomonitor of atmospheric levels of fluoride.

    abstract::The aim of the present study was to develop a standardised protocol for the use of Lolium perenne cultures to biomonitor the surroundings of an aluminium smelter. Five ecological stations, which corresponded to air quality network monitoring sites pertaining to the smelter, were selected for study. Cultures of L. pere...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2006.10.004

    authors: Rey-Asensio A,Carballeira A

    更新日期:2007-05-01 00:00:00

  • Remediation of mercury contaminated soil, water, and air: A review of emerging materials and innovative technologies.

    abstract::Mercury contamination in soil, water and air is associated with potential toxicity to humans and ecosystems. Industrial activities such as coal combustion have led to increased mercury (Hg) concentrations in different environmental media. This review critically evaluates recent developments in technological approaches...

    journal_title:Environment international

    pub_type: 杂志文章,评审

    doi:10.1016/j.envint.2019.105281

    authors: Wang L,Hou D,Cao Y,Ok YS,Tack FMG,Rinklebe J,O'Connor D

    更新日期:2020-01-01 00:00:00

  • Dietary exposure to dioxins and PCBs in a large cohort of pregnant women: results from the Norwegian Mother and Child Cohort Study (MoBa).

    abstract::Exposure to dioxins and polychlorinated biphenyls (PCBs) during pregnancy and breastfeeding may result in adverse health effects in children. Prenatal exposure is determined by the concentrations of dioxins and PCBs in maternal blood, which reflect the body burden obtained by long term dietary exposure. The aims of th...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2013.07.001

    authors: Caspersen IH,Knutsen HK,Brantsæter AL,Haugen M,Alexander J,Meltzer HM,Kvalem HE

    更新日期:2013-09-01 00:00:00

  • Prenatal and postnatal mercury exposure and blood pressure in childhood.

    abstract::Elevated blood pressure in childhood is an important risk factor for hypertension in adulthood. Environmental exposures have been associated with elevated blood pressure over the life course and exposure to mercury (Hg) has been linked to cardiovascular effects in adults. As subclinical vascular changes begin early in...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2020.106201

    authors: Farzan SF,Howe CG,Chen Y,Gilbert-Diamond D,Korrick S,Jackson BP,Weinstein AR,Karagas MR

    更新日期:2021-01-01 00:00:00

  • Particulate plastics as a vector for toxic trace-element uptake by aquatic and terrestrial organisms and human health risk.

    abstract::Particulate plastics in the terrestrial and aquatic environments are small plastic fragments or beads (i.e., 5 mm down to the nanometre range). They have been frequently referred to as 'micro-plastics' or 'nano-plastics'. Research has identified particulate plastics as a vector for toxic trace elements in the environm...

    journal_title:Environment international

    pub_type: 杂志文章,评审

    doi:10.1016/j.envint.2019.104937

    authors: Bradney L,Wijesekara H,Palansooriya KN,Obadamudalige N,Bolan NS,Ok YS,Rinklebe J,Kim KH,Kirkham MB

    更新日期:2019-10-01 00:00:00

  • Predominance of BDE-209 and other higher brominated diphenyl ethers in eggs of white stork (Ciconia ciconia) colonies from Spain.

    abstract::Polybrominated diphenyl ethers (PBDEs) are ubiquitous pollutants for which there is still a lack of knowledge about the environmental behavior and fate of the higher brominated congeners (octa- to deca-BDEs). In this study, the PBDE content and congener profiles in failed eggs from two colonies of white stork (Ciconia...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2010.11.013

    authors: Muñoz-Arnanz J,Sáez M,Aguirre JI,Hiraldo F,Baos R,Pacepavicius G,Alaee M,Jiménez B

    更新日期:2011-04-01 00:00:00

  • Monitoring lead in hair of children and adolescents of Alcalá de Henares, Spain. A study by gender and residential areas.

    abstract::In recent years there has been an increased interest from the European Union (EU) in the development of large Human Bio-monitoring (HBM) studies across Europe, especially biomonitoring toxic metals. In Spain, most studies using hair as a biomarker have been conducted to determine occupational or industrial exposures, ...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2014.03.010

    authors: Peña-Fernández A,Lobo-Bedmar MC,González-Muñoz MJ

    更新日期:2014-11-01 00:00:00

  • Prenatal exposure to substance of abuse: a worldwide problem.

    abstract::Substance abuse during pregnancy is an important public health issue affecting the mother and the growing infant. Preterm labor, miscarriage, abruption and postpartum hemorrhage are obstetric complications which have been associated with women who are dependent on abused substances. Moreover, women are also at an incr...

    journal_title:Environment international

    pub_type: 杂志文章,评审

    doi:10.1016/j.envint.2013.01.011

    authors: Narkowicz S,Płotka J,Polkowska Ż,Biziuk M,Namieśnik J

    更新日期:2013-04-01 00:00:00

  • Human and veterinary antibiotics induce hormesis in plants: Scientific and regulatory issues and an environmental perspective.

    abstract::Veterinary and human pharmaceuticals have been widely used in the developed world, thus increasing their accumulation in the environment and thereby posing ecological risks. Earlier studies report that active pharmaceutical ingredients induce hormesis in plants, i.e. at low doses may enhance plant health whereas at hi...

    journal_title:Environment international

    pub_type: 杂志文章,评审

    doi:10.1016/j.envint.2018.08.035

    authors: Agathokleous E,Kitao M,Calabrese EJ

    更新日期:2018-11-01 00:00:00

  • Gene-environment interactions between GSTs polymorphisms and targeted epigenetic alterations in hepatocellular carcinoma following organochlorine pesticides (OCPs) exposure.

    abstract::Exposure to environmental pollutant organochlorine pesticides (OCPs) and the role of tumour suppressor GSTs gene polymorphisms as well as epigenetic alterations have all been well reported in hepatocarcinogenesis. However, the interplay between environmental risk factors and polymorphic tumour suppressor genes or epig...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2019.105313

    authors: Tian M,Zhao B,Martin FL,Morais CLM,Liu L,Huang Q,Zhang J,Shen H

    更新日期:2020-01-01 00:00:00

  • Potentially harmful elements (PHEs) in scalp hair, soil and metallurgical wastes in Mitrovica, Kosovo: the role of oral bioaccessibility and mineralogy in human PHE exposure.

    abstract::Internationally publicized impacts upon human health associated with potentially harmful element (PHE) exposure have been reported amongst internally displaced populations (IDPs) in Mitrovica, Kosovo, following the Kosovan War. Particular concern has surrounded the exposure to Pb indicated by the presence of highly el...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2013.07.014

    authors: Boisa N,Bird G,Brewer PA,Dean JR,Entwistle JA,Kemp SJ,Macklin MG

    更新日期:2013-10-01 00:00:00

  • The impact of flood and post-flood cleaning on airborne microbiological and particle contamination in residential houses.

    abstract::In January 2011, Brisbane, Australia, experienced a major river flooding event. We aimed to investigate its effects on air quality and assess the role of prompt cleaning activities in reducing the airborne exposure risk. A comprehensive, multi-parameter indoor and outdoor measurement campaign was conducted in 41 resid...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2014.04.001

    authors: He C,Salonen H,Ling X,Crilley L,Jayasundara N,Cheung HC,Hargreaves M,Huygens F,Knibbs LD,Ayoko GA,Morawska L

    更新日期:2014-08-01 00:00:00

  • Hexachloronorbornene-based flame retardants in humans: levels in maternal serum and milk.

    abstract::Five hexachloronorbornene-based flame retardants, Dechlorane Plus (DP), Dechlorane 602 (Dec 602), Dechlorane 603 (Dec 603), Dechlorane 604 (Dec 604) and hexachlorocyclopentadienyl-dibromocyclooctane (HCDBCO), were measured in human milk and maternal serum. Dec 602, Dec 603 and HCDBCO were detected in both sample matri...

    journal_title:Environment international

    pub_type: 杂志文章

    doi:10.1016/j.envint.2014.01.010

    authors: Zhou SN,Siddique S,Lavoie L,Takser L,Abdelouahab N,Zhu J

    更新日期:2014-05-01 00:00:00