Rapid accurate point-of-care tests combining diagnostics and antimicrobial resistance prediction for Neisseria gonorrhoeae and Mycoplasma genitalium.

Abstract:

:In addition to inadequate access to early diagnosis and treatment with antimicrobial agents for patients and sexual contacts, management and control of STIs is significantly challenged by emergence and spread of antimicrobial resistance (AMR), particularly for STIs such as Neisseria gonorrhoeae and Mycoplasma genitalium This is further compounded by use of nucleic acid amplification techniques for diagnosis, resulting in reduced phenotypic AMR testing for N. gonorrhoeae and absence or suboptimal AMR surveillance for guiding treatment of both STIs in many settings. Rapid accurate point-of-care (POC) tests for diagnosis of all STIs would be valuable but to significantly impact treatment precision and management of N. gonorrhoeae and M. genitalium infections, combinations of rapid POC diagnostic and AMR testing (POC-AMR) will likely be required. This strategy would combat STI burden and AMR emergence and spread by enabling diagnosis and individualised treatment at the first healthcare visit, potentially reducing selection pressure on recommended antimicrobials, reducing transmission of resistant strains and providing means for AMR surveillance. Microfluidic and nanotechnology platforms under development for rapid detection of STIs provide a basis to also develop molecular rapid POC-AMR prediction. A number of prototypic devices are in the pipeline but none as yet approved for routine use. However, particularly for N. gonorrhoeae, more knowledge is required to assess which antimicrobials lend themselves to a genotypic POC-AMR approach, in relation to genotypic-phenotypic associations and potential impact clinically and epidemiologically. Key for successful deployment will include also understanding cost-effectiveness, cost-consequences and acceptability for key stakeholders.

journal_name

Sex Transm Infect

authors

Sadiq ST,Mazzaferri F,Unemo M

doi

10.1136/sextrans-2016-053072

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

S65-S68

issue

S4

eissn

1368-4973

issn

1472-3263

pii

sextrans-2016-053072

journal_volume

93

pub_type

杂志文章
  • Acute hepatitis A infection after hepatitis A immunity in a HIV-positive individual.

    abstract::Hepatitis A is a self-limiting infection caused by the hepatitis A virus (HAV), transmitted predominantly by the faecal-oral route including some sexual practices. Outbreaks are commonly reported in the men who have sex with men (population. Previous exposure is thought to provide life-long immunity against subsequent...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2017-053246

    authors: Lee MJ,Douthwaite S,Kulasegaram R

    更新日期:2018-02-01 00:00:00

  • Spatial distribution and cluster analysis of risky sexual behaviours and STDs reported by Chinese adults in Guangzhou, China: a representative population-based study.

    abstract:OBJECTIVES:To assess associations between residences location, risky sexual behaviours and sexually transmitted diseases (STDs) among adults living in Guangzhou, China. METHODS:Data were obtained from 751 Chinese adults aged 18-59 years in Guangzhou, China, using stratified random sampling by using spatial epidemiolog...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052268

    authors: Chen W,Zhou F,Hall BJ,Wang Y,Latkin C,Ling L,Tucker JD

    更新日期:2016-06-01 00:00:00

  • Donovanosis.

    abstract::Donovanosis, a chronic cause of genital ulceration, has recently been the subject of renewed interest after a long period of relative obscurity. The causative organism, Calymmatobacterium granulomatis, has been cultured for the first time in many years and a polymerase chain reaction diagnostic using a colorimetric de...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.78.6.452

    authors: O'Farrell N

    更新日期:2002-12-01 00:00:00

  • Identification of chlamydia and gonorrhoea among women in rural Haiti: maximising access to treatment in a resource poor setting.

    abstract:OBJECTIVE:To develop a risk assessment algorithm that will increase the identification and treatment of women with cervical infection in rural Haiti. METHODS:Study participants were randomly selected from new patients who accessed services at a women's health clinic in rural Haiti between June 1999 and December 2002. ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2005.016733

    authors: Smith Fawzi MC,Lambert W,Singler J,Léandre F,Nevil P,Bertrand D,Claude MS,Bertrand J,Louissaint M,Jeannis L,Ferrer JG,Cook EF,Salazar JJ,Farmer P,Mukherjee JS

    更新日期:2006-04-01 00:00:00

  • Reaching homeless youths for Chlamydia trachomatis and Neisseria gonorrhoeae screening in Denver, Colorado.

    abstract:BACKGROUND AND RATIONALE:The availability of urine based testing for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) provides a unique opportunity to screen for these pathogens outside traditional clinical settings. The researchers investigated the feasibility of street based CT/GC screening in the context of...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.78.5.357

    authors: Van Leeuwen JM,Rietmeijer CA,LeRoux T,White R,Petersen J

    更新日期:2002-10-01 00:00:00

  • Surveillance of HIV in the army of the Republic of Cyprus (SHARC); rationale, design, and implementation of an inexpensive system.

    abstract:OBJECTIVES:To design and implement an HIV surveillance system using periodic cross sectional prevalence surveys in National Guard recruits of the Republic of Cyprus. METHODS:HIV infection surveillance used unlinked anonymous screening (UAS) methodology, which tested residual blood originally collected for other purpos...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.78.1.50

    authors: Kyriakides T,Eleftheriou A,Michaelides N,Papantoniou L

    更新日期:2002-02-01 00:00:00

  • Effect of weighting for sampling and non-response on estimates of STI prevalence in the third British National Survey of Sexual Attitudes and Lifestyles (Natsal-3).

    abstract:OBJECTIVES:In addition to researcher-designed sampling biases, population-representative surveys for biomarker measurement of STIs often have substantial missingness due to non-contact, non-consent and other study-implementation issues. STI prevalence estimates may be biased if this missingness is related to STI risk. ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2019-054342

    authors: Harling G,Copas A,Clifton S,Johnson AM,Field N,Sonnenberg P,Mercer CH

    更新日期:2020-11-01 00:00:00

  • The effects of scale on the costs of targeted HIV prevention interventions among female and male sex workers, men who have sex with men and transgenders in India.

    abstract:BACKGROUND:The India AIDS Initiative (Avahan) project is involved in rapid scale-up of HIV-prevention interventions in high-risk populations. This study examines the cost variation of 107 non-governmental organisations (NGOs) implementing targeted interventions, over the start up (defined as period from project incepti...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2009.038547

    authors: Chandrashekar S,Guinness L,Kumaranayake L,Reddy B,Govindraj Y,Vickerman P,Alary M

    更新日期:2010-02-01 00:00:00

  • Contribution of sexual practices (other than anal sex) to bacterial sexually transmitted infection transmission in men who have sex with men: a cross-sectional analysis using electronic health records.

    abstract:OBJECTIVE:We quantified the proportion of cases and risk of primary syphilis (PS), urethral chlamydia (UCT) and urethral gonorrhoea (UGC) attributable to sexual practices other than anal sex. METHODS:In this cross-sectional study, electronic records for men who have sex with men (MSM) who attended the Melbourne Sexual...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2013-051103

    authors: Nash JL,Hocking JS,Read TR,Chen MY,Bradshaw CS,Forcey DS,Fairley CK

    更新日期:2014-02-01 00:00:00

  • The descriptive epidemiology of male sex workers in Pakistan: a biological and behavioural examination.

    abstract:OBJECTIVES:There is a dearth of published information on the characteristics of sex workers in Pakistan. This study sought to characterise and compare hijra and non-hijra sex workers from eight large cities in Pakistan. DESIGN:χ(2) and Kruskal-Wallis tests, and multivariable logistic regression were used where appropr...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2009.041335

    authors: Shaw SY,Emmanuel F,Adrien A,Holte-McKenzie M,Archibald CP,Sandstrom P,Blanchard JF

    更新日期:2011-02-01 00:00:00

  • National prevalence estimates of chlamydia and gonorrhoea in the Netherlands.

    abstract:OBJECTIVES:National prevalence estimates of Chlamydia trachomatis (chlamydia) and Neisseria gonorrhoeae (gonorrhoea) are important for providing insights in the occurrence and control of these STIs. The aim was to obtain national prevalence estimates for chlamydia and gonorrhoea and to investigate risk factors associat...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2017-053478

    authors: Heijne JCM,van den Broek IVF,Bruisten SM,van Bergen JEA,de Graaf H,van Benthem BHB

    更新日期:2019-02-01 00:00:00

  • The changing epidemiology of prevalent diagnosed HIV infections in England, Wales, and Northern Ireland, 1997 to 2003.

    abstract:OBJECTIVES:To present the current epidemiology of prevalent diagnosed HIV infections in England, Wales, and Northern Ireland (E, W, & NI) and describe trends over time. METHODS:Descriptive analyses of the annual national Survey of Prevalent HIV Infections Diagnosed (SOPHID) for the period 1997 to 2003. RESULTS:In 200...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2004.012070

    authors: Rice BD,Payne LJ,Sinka K,Patel B,Evans BG,Delpech V

    更新日期:2005-06-01 00:00:00

  • Oral examination: a screening tool for HIV infection?

    abstract:OBJECTIVE:To estimate the predictive values for HIV infection of diagnosis of oral manifestations of the infection. METHOD:Prevalence of oral manifestations was compared in cross sectional blinded clinical examinations of homosexual men attending a genitourinary medicine clinic. Data were extrapolated to populations i...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.74.5.345

    authors: Robinson PG,Challacombe SJ,Sheiham A

    更新日期:1998-10-01 00:00:00

  • A new multiplex real-time PCR test for HSV1/2 and syphilis: an evaluation of its impact in the laboratory and clinical setting.

    abstract:OBJECTIVES:To develop, evaluate and implement a new multiplex real-time PCR test for the detection of herpes simplex virus (HSV)1, HSV2 and syphilis in a single sample using a single test. METHODS:A multiplex real-time PCR test detecting HSV1, HSV2 and Treponema pallidum was designed, validated and evaluated for a per...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2009.040451

    authors: Scott LJ,Gunson RN,Carman WF,Winter AJ

    更新日期:2010-12-01 00:00:00

  • Hopes interrupted: accessing and experiences of antiretroviral therapy in South Africa.

    abstract:OBJECTIVES:Using the example of South Africa, this study aimed to examine and obtain a better understanding of the experiences and challenges of urban and rural patients on antiretroviral therapy (ART) in accessing this complex treatment in a resource-limited setting. METHODS:Following a narrative approach, in-depth i...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2011-050140

    authors: Fried J,Harris B,Eyles J

    更新日期:2012-03-01 00:00:00

  • Understanding trends in genital Chlamydia trachomatis can benefit from enhanced surveillance: findings from Australia.

    abstract:OBJECTIVES:To determine trends and correlates of chlamydia positivity among young heterosexuals attending Australian sexual health services and to compare these with population-based notification data. METHODS:Data from 18 sexual health services and the national notification scheme were analysed. A χ2 test assessed tr...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2011-050423

    authors: Ali H,Guy RJ,Fairley CK,Wand H,Chen MY,Dickson B,O'Connor CC,Marshall L,Grulich AE,Kaldor JM,Hellard ME,Donovan B,ACCESS Collaboration.

    更新日期:2012-11-01 00:00:00

  • An introduction to mathematical models in sexually transmitted disease epidemiology.

    abstract::Mathematical models serve a number of roles in understanding sexually transmitted infection epidemiology and control. This article seeks to provide the non-mathematician with a description of their construction and use and presents illustrative examples from sexually transmitted infection epidemiology. ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.78.1.7

    authors: Garnett GP

    更新日期:2002-02-01 00:00:00

  • High yield of reinfections by home-based automatic rescreening of Chlamydia positives in a large-scale register-based screening programme and determinants of repeat infections.

    abstract:INTRODUCTION:In a systematic internet-based Chlamydia Screening Implementation Programme in The Netherlands, all chlamydia-positive participants automatically received a testkit after 6 months to facilitate early detection of repeat infections. The authors describe participation in repeat testing and prevalence and det...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2011-050455

    authors: Götz HM,van den Broek IV,Hoebe CJ,Brouwers EE,Pars LL,Fennema JS,Koekenbier RH,van Ravesteijn S,Op de Coul EL,van Bergen J

    更新日期:2013-02-01 00:00:00

  • Risk attitudes, risky sexual behaviours and willingness to test negative for syphilis using lottery-based financial incentives among Chinese men who have sex with men.

    abstract:BACKGROUND:Individuals with risk-loving attitudes may be more likely to participate in high-risk sex and gambling. We investigated whether a lottery-based financial incentive to have a negative syphilis test may attract Chinese men who have sex with men (MSM) who practised risky sexual behaviours. METHODS:In July 2018...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2019-054072

    authors: Ong JJ,Li CC,Fu H,Nie J,Tang W,Chang W,Smith MK,Marks M,Yang B,Wang C,Tucker J

    更新日期:2020-08-01 00:00:00

  • 'Side effects' are 'central effects' that challenge retention in HIV treatment programmes in six sub-Saharan African countries: a multicountry qualitative study.

    abstract:OBJECTIVES:To explore the bodily and relational experience of taking antiretroviral therapy (ART) and the subsequent effect on retention in HIV care in six sub-Saharan African countries. METHODS:In-depth interviews were conducted with 130 people living with HIV (PLHIV) who had initiated ART, 38 PLHIV who were lost to ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sextrans-2016-052971

    authors: Renju J,Moshabela M,McLean E,Ddaaki W,Skovdal M,Odongo F,Bukenya D,Wamoyi J,Bonnington O,Seeley J,Zaba B,Wringe A

    更新日期:2017-07-01 00:00:00

  • Who is being tested for genital chlamydia in primary care?

    abstract:OBJECTIVES:To explore current patterns of testing for genital chlamydial infection in primary care, and to identify practice characteristics influencing testing rates. METHOD:Aggregate numbers of chlamydia tests and results for each practice in Nottingham Health District were matched to practice characteristics. Age s...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.79.3.234

    authors: Kufeji O,Slack R,Cassell JA,Pugh S,Hayward A

    更新日期:2003-06-01 00:00:00

  • Illicit drug use in sexual settings ('chemsex') and HIV/STI transmission risk behaviour among gay men in South London: findings from a qualitative study.

    abstract:BACKGROUND:'Chemsex' is a colloquial term used in the UK that describes sex under the influence of psychoactive substances (typically crystal methamphetamine, mephedrone and gamma-hydroxybutyric acid (GHB)/gamma-butyrolactone (GBL)). Recently, concern has been raised as to the impact of such behaviour on HIV/sexually t...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sextrans-2015-052052

    authors: Bourne A,Reid D,Hickson F,Torres-Rueda S,Weatherburn P

    更新日期:2015-12-01 00:00:00

  • Comparison of urine, first and second endourethral swabs for PCR based detection of genital Chlamydia trachomatis infection in male patients.

    abstract:OBJECTIVES:To compare endourethral swabs and urine as diagnostic specimens for the detection of genital Chlamydia trachomatis infection using the polymerase chain reaction (PCR), in male patients attending a genitourinary clinic and to assess whether the first endourethral swab used solely for diagnosing gonococcal inf...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.77.6.423

    authors: Sugunendran H,Birley HD,Mallinson H,Abbott M,Tong CY

    更新日期:2001-12-01 00:00:00

  • Evaluation and enumeration of online test providers for sexually transmitted infections, specifically chlamydia, in the Netherlands.

    abstract:OBJECTIVES:Online testing for STIs might complement regular care provided by general practitioners or STI clinics. Two types of online testing can be distinguished, self-testing and self-sampling (sending sample to a laboratory for diagnosis). Online testing can occur without consultation with a healthcare professional...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2018-053771

    authors: den Daas C,Sukel B,Bos H,van den Broek I 1st

    更新日期:2019-08-01 00:00:00

  • An immunofiltration device for the simultaneous detection of non-treponemal and treponemal antibodies in patients with syphilis.

    abstract:OBJECTIVE:The development of a rapid immunofiltration (flow-through) test for the simultaneous detection of non-treponemal and treponemal antibodies in the serum of patients with syphilis. METHODS:The assay is rapid, inexpensive, and requires limited expertise in interpreting the results. The test is based on the prin...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2010.042937

    authors: Castro AR,Mody HC,Parab SY,Patel MT,Kikkert SE,Park MM,Ballard RC

    更新日期:2010-12-01 00:00:00

  • Inequalities in access to genitourinary medicine clinics in the UK: results from a mystery shopper survey.

    abstract:STUDY DESIGN:This study investigated whether access to genitourinary medicine (GUM) clinics meets UK-recommended standards. METHODS:In January 2014 and 2015, postal questionnaires about appointment and service characteristics were sent to lead clinicians of UK GUM clinics. In February 2014 and 2015, researchers posing...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2016-052882

    authors: Foley E,Furegato M,Hughes G,Board C,Hayden V,Prescott T,Shone E,Patel R

    更新日期:2017-11-01 00:00:00

  • Formative design and evaluation of patient-delivered partner therapy informational materials and packaging.

    abstract:OBJECTIVE:To develop and evaluate instructional and packaging materials for patient-delivered partner therapy (PDPT). METHODS:64 patients participated from an urban US sexually transmitted infection (STI) clinic. The research comprised three phases: individual interviews to elicit attitudes and beliefs regarding PDPT ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2008.033746

    authors: McBride K,Goldsworthy RC,Fortenberry JD

    更新日期:2009-04-01 00:00:00

  • Risky sexual behaviour in context: qualitative results from an investigation into risk factors for seroconversion among gay men who test for HIV.

    abstract:OBJECTIVES:The INSIGHT case-control study confirmed that HIV serodiscordant unprotected anal intercourse (SdUAI) remains the primary risk factor for HIV infection in gay men in England. This paper uses qualitative follow-up data to examine the contexts of SdUAI and other risk factors among the case-control study partic...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2008.031468

    authors: Elam G,Macdonald N,Hickson FC,Imrie J,Power R,McGarrigle CA,Fenton KA,Gilbart VL,Ward H,Evans BG,INSIGHT Collaborative Research Team.

    更新日期:2008-11-01 00:00:00

  • Injection drug use, sexual risk, violence and STI/HIV among Moscow female sex workers.

    abstract:BACKGROUND/OBJECTIVES:The HIV prevalence in Eastern Europe and Central Asia continues to increase. While injection drug use (IDU) is leading factor, heterosexual transmission is on the rise. Little is known about female sex workers (FSWs) in the region despite the central role of commercial sex in heterosexual sexually...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2011-050171

    authors: Decker MR,Wirtz AL,Baral SD,Peryshkina A,Mogilnyi V,Weber RA,Stachowiak J,Go V,Beyrer C

    更新日期:2012-06-01 00:00:00

  • Evaluation of an enzymatic Chlamydia trachomatis point-of-care rapid assay in Rwanda: the BioChekSwab Rapid Test.

    abstract:OBJECTIVES:We evaluated the performance of an enzymatic point-of-care rapid test for Chlamydia trachomatis (CT) (the BioChekSwab CT Rapid Test, EnZtek Diagnostics, Rio Vista, California, USA), which detects CT's Peptidase 123CBV enzyme and provides a result 15 min after specimen collection. METHODS:Two endocervical sw...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052202

    authors: De Baetselier I,Mwambarangwe L,Cuylaerts V,Musengamana V,Agaba S,Kestelyn E,van de Wijgert J,Crucitti T

    更新日期:2016-09-01 00:00:00