Enhancing linalool production by engineering oleaginous yeast Yarrowia lipolytica.

Abstract:

:In this study, stepwise increases in linalool production were obtained by combining metabolic engineering and process optimization of an unconventional oleaginous yeast Yarrowia lipolytica. The linalool synthetic pathway was successfully constructed by heterologously expressing a codon-optimized linalool synthase gene from Actinidia arguta in Y. lipolytica. To enhance linalool productivity, key genes involved in the mevalonate pathway were overexpressed in different combinations. Moreover, the overexpression of mutant ERG20F88W-N119W gene resulted in further linalool production. A maximum linalool titre of 6.96±0.29mg/L was achieved in shake flasks, which was the highest level ever reported in yeasts.

journal_name

Bioresour Technol

journal_title

Bioresource technology

authors

Cao X,Wei LJ,Lin JY,Hua Q

doi

10.1016/j.biortech.2017.06.105

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

1641-1644

issue

Pt B

eissn

0960-8524

issn

1873-2976

pii

S0960-8524(17)31009-X

journal_volume

245

pub_type

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