Abstract：
:The abnormal aggregation of amyloid β-peptide (Aβ) is central to the pathogenesis of Alzheimer's disease, the major form of dementia. Aromatic π-π interactions have been suggested to play a crucial role in the aggregation of not only Aβ, but also other amyloidogenic proteins. In this study, each or all phenylalanine (Phe) residues at the 4th, 19th, and 20th positions of Aβ-(1-40) were substituted by hydrophobic cyclohexylalanine (Cha), which is sterically similar to Phe, but lacks π-electrons, to reveal effects of interactions involving π-electrons on the aggregation of Aβ both in aqueous solution and GM1-containing membranes. We found that each Cha substitution significantly inhibited fibril formation by Aβ, indicating a pivotal role of aromatic interactions. Furthermore, the Aβ analog with three Cha residues effectively retarded the fibrillation of the wild-type Aβ.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Genji M,Yano Y,Hoshino M,Matsuzaki Kdoi
10.1248/cpb.c17-00203subject
Has Abstractpub_date
2017-01-01 00:00:00pages
668-673issue
7eissn
0009-2363issn
1347-5223journal_volume
65pub_type
杂志文章abstract：:Three new acylated flavonol glycosides, cypellogins A (1), B (2) and C (3), along with eight known phenolic compounds, were isolated from the dried leaves of Eucalyptus cypellocarpa, and their structures were elucidated using spectroscopic methods, including 2D NMR experiments and chemical evidence. ...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.53.1345
更新日期：2005-10-01 00:00:00
abstract：:Six new compounds, diospyrolide (1), diospyrolidone (2), diethyl (2R)-malate (3), 3-(E)-coumaroylbetulin-28-yl ethyl nonanedioate (4), 3-(E)-coumaroylbetulin-28-yl ethyl succinate (5), and 3-(E)-coumaroylbetulin-28-yl ethyl (2R)-2-hydroxysuccinate (6), have been isolated from the heartwood of Diospyros maritima. Compo...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.48.1211
更新日期：2000-08-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.55.44
更新日期：2007-01-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.c12-00785
更新日期：2012-01-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.39.930
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.52.861
更新日期：2004-07-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.46.482
更新日期：1998-03-01 00:00:00
abstract：:Three new natural sesquiterpene coumarins, isofeterin (1), lehmannolol (3), sinkianone (4), and one known compound, lehmannolone (2), were isolated from the roots of Ferula teterrima and Ferula sinkiangensis. Their chemical structures were established on the basis of spectroscopic analysis, including X-ray crystallogr...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.54.1595
更新日期：2006-11-01 00:00:00
abstract：:An efficient one-pot step by step t-BuOK-mediated procedure for the synthesis of N-arylindoles has been developed in moderate to good yields. The protocol involves the consecutive deprotection of N-arylsulfonylindoles as latent indoles and subsequent S(N)Ar reactions with activated aryl halides. This tandem reaction a...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.57.321
更新日期：2009-03-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.37.2322
更新日期：1989-09-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.42.167
更新日期：1994-01-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.49.629
更新日期：2001-05-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.54.230
更新日期：2006-02-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.47.1436
更新日期：1999-10-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.48.283
更新日期：2000-02-01 00:00:00
abstract：:Phthalimidoacetyl isothiocyanate underwent addition-cyclization reactions with some nitrogen and carbon nucleophilic reagents. Simultaneous or subsequent cyclization of the obtained adducts gave target heterocyclic systems such as 1,2,4-triazoles, 1,3-diazines, 1,3-oxazines and thiourea attached to a phthalimido moiet...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.c16-00099
更新日期：2016-01-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.46.1820
更新日期：1998-11-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.48.2003
更新日期：2000-12-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.38.538
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.43.359
更新日期：1995-02-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.39.154
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abstract：:N-Nitrosodialkylamines are alkylating carcinogens which are metabolically activated to alpha-hydroxy nitrosamines through oxidative dealkylation by cytochrome P450. In this study, the dealkylation step in the activation of N-nitrosodibenzylamine (NDBz) was investigated with metalloporphyrin/oxidant model systems under...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.43.2173
更新日期：1995-12-01 00:00:00
abstract：:A series of benzo[b]furan derivatives having a five-membered heterocyclic substituent at the 2-position were prepared from 2-(1-chloro-2-formylvinyl)benzo[b]furans (2) and 2-(4-alkylcarbamoylbuta-1,3-dienyl)benzo[b]furans. These 2-heterocyclic benzo[b]furans were evaluated for their cysteinyl leukotriene receptor (cys...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.c12-00560
更新日期：2012-01-01 00:00:00
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journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.c16-00318
更新日期：2016-10-01 00:00:00
abstract：:Chalcone (3) has been synthesized as a new chalcone derivative bearing benzofuran moiety at 1 position. Such chalcone was used as a model dielectrophile applied to react with some nucleophiles such as 5-amino pyrazoles, 5-amino-1,2,4-triazole, 2-aminobenzimidazole, and 6-uraciles under Michael reaction conditions and ...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.c15-00922
更新日期：2016-01-01 00:00:00
abstract：:Three new naphthoquinone derivatives, 6-(1-ethoxyethyl)plumbagin (16), ethylidene-3,3'-biplumbagin (17), and ethylidene-3,6'-biplumbagin (18), were isolated, in addition to six known naphthoquinones, isozeylanone (10), 3,3'-biplumbagin (11), chitranone (12), methylene-3,3'-biplumbagin (13), 2,3-epoxyplumbagin (14), an...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.50.590
更新日期：2002-05-01 00:00:00
abstract：:In addition to 19-dydroxybaccatin III, 1beta-hydroxy-5 alpha-deacetylbaccatin I, taxayuntin G and 13-O-deacetyltaxumairol Z (4), three new taxane diterpenoids, taxumairols X (1), Y (2), Z (3) have been isolated from extracts of the Formosan Taxus mairei (LEMEE & LEVL.) S. Y. HU. Compounds 1-2 belong to the 11(15-->1)-...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.50.1561
更新日期：2002-12-01 00:00:00
abstract：:The synthesis and structure-activity relationships of a series of new azabicycloalkanes as 5-HT3 (serotonin-3) receptor antagonists are described. Our study on the azabicycloalkaneacetamide derivatives showed that 2,3-dihydroindole as the aromatic ring moiety afforded potent 5-HT3 receptor antagonist activity, as judg...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.43.1351
更新日期：1995-08-01 00:00:00
abstract：:The reaction of the N-furfuryloxamic acid sodium salt (12) with 1,1'-oxalyldiimidazole (ODI) yielded the imidazolide (13) as an intermediate, and this directly reacted with 2-aminothiazole derivatives (14) or 2-aminobenzothiazole derivatives (15) under essentially neutral conditions to afford the N'-12-(substituted th...
journal_title：Chemical & pharmaceutical bulletin
pub_type： 杂志文章
doi：10.1248/cpb.48.1363
更新日期：2000-09-01 00:00:00
