Abstract:
BACKGROUND:Limited evidence exists on the association between exposure to Helicobacter pylori infection early in life, including fetal life, and neurodevelopment in childhood. METHODS:We used prospective data on 352 mother-child pairs and cross-sectional data on 674 children to assess the association of maternal and child's H. pylori seropositivity correspondingly on child's neurodevelopment at age four in the Rhea birth cohort in Crete, Greece. Blood levels of immunoglobulin G antibodies to 12 H. pylori proteins were measured using multiplex serology. Child's neurodevelopment at age four was assessed using the McCarthy Scales of Children's Abilities. Linear regression models were used to explore the associations after adjusting for potential confounders. RESULTS:Helicobacter pylori seroprevalence (95% CI) in cord blood, representing maternal status, was 41.5% (36.3%, 46.8%) and in 4 years old children was 6.5% (95% CI 4.8%, 8.7%). Children of H. pylori seropositive mothers had lower score in the general cognitive (-3.87, 95% CI -7.02, -0.72), verbal (-2.96, 95% CI -6.08, 0.15), perceptual performance (-3.37, 95% CI -6.60, -0.15), quantitative (-2.85, 95% CI -6.28, 0.58), and memory scale (-3.37, 95% CI -6.67, -0.07) compared to those of seronegative mothers. Seropositivity in cord blood specifically to GroEl and NapA - two of the 12 H. pylori proteins investigated - was associated with lower scores in almost all scales. At age four, H. pylori seropositive children performed worst in neurodevelopment assessment compared to their seronegative counterparts although no association reached statistically significant level. CONCLUSIONS:Helicobacter pylori infection in early life may be an important but preventable risk factor for poor neurodevelopment.
journal_name
Paediatr Perinat Epidemioljournal_title
Paediatric and perinatal epidemiologyauthors
Karachaliou M,Chatzi L,Michel A,Kyriklaki A,Kampouri M,Koutra K,Roumeliotaki T,Chalkiadaki G,Stiakaki E,Pawlita M,Waterboer T,Kogevinas M,de Sanjose Sdoi
10.1111/ppe.12374subject
Has Abstractpub_date
2017-07-01 00:00:00pages
374-384issue
4eissn
0269-5022issn
1365-3016journal_volume
31pub_type
杂志文章abstract::The caesarean delivery rate has become a commonly used measure intended to reflect the quality of obstetric care. At least 25% of all primary caesarean deliveries occur electively, i.e. to women who are not in labour. This study is intended to validate a previously published model designed to use ICD-9-CM codes to ide...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2003.00540.x
更新日期:2004-03-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2008.00970.x
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pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1046/j.1365-3016.2000.00242.x
更新日期:2000-04-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2005.00634.x
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2007.00863.x
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12399
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2010.01136.x
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
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journal_title:Paediatric and perinatal epidemiology
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1046/j.1365-3016.2003.00476.x
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1990.tb00628.x
更新日期:1990-04-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,多中心研究
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更新日期:2007-03-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1995.tb00148.x
更新日期:1995-07-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12152
更新日期:2014-11-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12023
更新日期:2013-01-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1046/j.1365-3016.2001.00361.x
更新日期:2001-07-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12731
更新日期:2020-10-30 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12120
更新日期:2014-05-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1995.tb00168.x
更新日期:1995-10-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2007.00830.x
更新日期:2007-07-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,随机对照试验
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更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:A few studies have indicated an increased risk of epilepsy in children conceived by fertility treatment possibly due to characteristics of the infertile couple rather than the treatment. We therefore aimed to investigate the association between parental infertility, fertility treatment, and epilepsy in the o...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12301
更新日期:2016-09-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2004.00625.x
更新日期:2005-01-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12471
更新日期:2018-07-01 00:00:00
abstract::Age at menarche is correlated within families, but estimates of the heritability of menarcheal age have a wide range (0.45-0.95). We examined the familial resemblance for age at menarche and the extent to which this is due to genetic and shared environmental factors. Between 2003 and 2010 data were retrospectively col...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2010.01183.x
更新日期:2011-05-01 00:00:00