Pharmacological intervention of MKL/SRF signaling by CCG-1423 impedes endothelial cell migration and angiogenesis.

abstract：:During embryonic development, the lymphatic system emerges by transdifferentiation from the cardinal vein. Although lymphatic and blood vasculature share a close molecular and developmental relationship, they display distinct features and functions. However, even after terminal differentiation, transitions between blo...

journal_title：Angiogenesis

authors： Brönneke S,Brückner B,Peters N,Bosch TC,Stäb F,Wenck H,Hagemann S,Winnefeld M

更新日期：2012-06-01 00:00:00

abstract：:Anti-VEGF (vascular endothelial growth factor) therapy with the monoclonal antibody bevacizumab can cause gastrointestinal (GI) perforations. In recent years it became apparent that GI perforations also occur during treatment with antiangiogenic tyrosine kinase inhibitors (TKIs). It is of clinical importance to consid...

journal_title：Angiogenesis

authors： Walraven M,Witteveen PO,Lolkema MP,van Hillegersberg R,Voest EE,Verheul HM

更新日期：2011-05-01 00:00:00

abstract：:Kaposi's sarcoma (KS) is a vascular neoplasm caused by infection of endothelial or endothelial precursor cells with the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8). Research efforts have focused on defining the molecular events explaining how KSHV promotes pathological angiogenesis and KS tumor formation. mTOR...

journal_title：Angiogenesis

authors： Ma T,Patel H,Babapoor-Farrokhran S,Franklin R,Semenza GL,Sodhi A,Montaner S

更新日期：2015-10-01 00:00:00

abstract：:The fusion protein tTF-NGR consists of the extracellular domain of the thrombogenic human tissue factor (truncated tissue factor, tTF) and the peptide GNGRAHA (NGR), a ligand of the surface protein CD13 (aminopeptidase N), upregulated on endothelial cells of tumor vessels. tTF-NGR preferentially activates blood coagul...

journal_title：Angiogenesis

authors： Persigehl T,Ring J,Bremer C,Heindel W,Holtmeier R,Stypmann J,Claesener M,Hermann S,Schäfers M,Zerbst C,Schliemann C,Mesters RM,Berdel WE,Schwöppe C

更新日期：2014-01-01 00:00:00

abstract：:In the adult, new vessels and red blood cells form in response to hypoxia. Here, the oxygen-sensing system (PHD-HIF) has recently been put into focus, since the prolyl-hydroxylase domain proteins (PHD) and hypoxia-inducible factors (HIF) are considered as potential therapeutic targets to treat ischemia, cancers or age...

journal_title：Angiogenesis

authors： Metikala S,Neuhaus H,Hollemann T

更新日期：2016-04-01 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases (VEGFRs). The extracellular domain of VEGFRs consists of seven Ig-homology domains, of which D2-3 form the ligand-binding site, while the membrane proximal domains D4-7 are involve...

journal_title：Angiogenesis

authors： Thieltges KM,Avramovic D,Piscitelli CL,Markovic-Mueller S,Binz HK,Ballmer-Hofer K

更新日期：2018-08-01 00:00:00

abstract：:Vascular endothelial (VE) cadherin is a key component of endothelial adherens junctions (AJs) and plays an important role in maintaining vascular integrity. Endocytosis of VE-cadherin regulates junctional strength and a decrease of surface VE-cadherin reduces vascular stability. However, disruption of AJs is also a re...

journal_title：Angiogenesis

authors： Chrifi I,Louzao-Martinez L,Brandt MM,van Dijk CGM,Bürgisser PE,Zhu C,Kros JM,Verhaar MC,Duncker DJ,Cheng C

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:There are currently no validated biomarkers predicting bevacizumab treatment outcome or toxicity. We combined biomarker data from six phase III trials of bevacizumab to assess whether genetic variation in vascular endothelial growth factor-A (VEGF-A) pathway or hypertension-related genes are associated with bev...

journal_title：Angiogenesis

authors： Lambrechts D,Moisse M,Delmar P,Miles DW,Leighl N,Escudier B,Van Cutsem E,Bansal AT,Carmeliet P,Scherer SJ,de Haas S,Pallaud C

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:EPLIN (epithelial protein lost in neoplasm) is a cytoskeletal associated protein involved in the regulation of actin dynamics and subsequently in cell motility. EPLIN expression is frequently reduced in a variety of cancer cells and tissues and this loss may account for increased invasive traits in cancer ce...

journal_title：Angiogenesis

authors： Sanders AJ,Ye L,Mason MD,Jiang WG

更新日期：2010-12-01 00:00:00

abstract：:Ovarian cancer (OC) is associated with poor survival because there are a limited number of effective therapies. Two processes key to OC progression, angiogenesis and immune evasion, act synergistically to promote tumor progression. Tumor-associated angiogenesis promotes immune evasion, and tumor-related immune respons...

journal_title：Angiogenesis

authors： García-Martínez E,Redondo A,Piulats JM,Rodríguez A,Casado A

更新日期：2020-11-01 00:00:00

abstract：:Due to their involvement in many physiologic and pathologic processes, there is a great interest in identifying new molecular pathways that mediate the formation and function of blood and lymphatic vessels. Vascular research increasingly involves the image-based analysis and quantification of vessel networks in tissue...

journal_title：Angiogenesis

authors： Montoya-Zegarra JA,Russo E,Runge P,Jadhav M,Willrodt AH,Stoma S,Nørrelykke SF,Detmar M,Halin C

更新日期：2019-05-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) play a critical role in the repair of damaged blood vessels and/or in the growth of new ones in ischemic tissues. Elevated levels of oxygen radicals, which accumulate in the ischemic tissue, could compromise the angiogenic potential of EPCs. To determine if oxidative stress alters t...

journal_title：Angiogenesis

authors： Curatola AM,Xu J,Hendricks-Munoz KD

更新日期：2011-09-01 00:00:00

abstract：:The establishment of a vascular network within tumours is a key step in the progression towards an aggressive, metastatic state, with poor prognosis. We have developed a novel in vitro model to specifically capture the interaction between endothelial cells and solid tumours. Micro-vascularised in vitro tumour construc...

journal_title：Angiogenesis

authors： Timmins NE,Dietmair S,Nielsen LK

更新日期：2004-01-01 00:00:00

abstract：:Early pregnancy is characterized by decidual adaption to the developing embryo involving angiogenesis and vascular growth. Failure of decidual vascular expansion is linked to diseases of pregnancy. Dendritic cells (DC) have been associated with vascular growth during early gestation, though it is unknown whether their...

journal_title：Angiogenesis

authors： Barrientos G,Tirado-González I,Freitag N,Kobelt P,Moschansky P,Klapp BF,Thijssen VL,Blois SM

更新日期：2013-04-01 00:00:00

abstract：:VEGF-A is a crucial growth factor for blood vessel homeostasis and pathological angiogenesis. Due to alternative splicing of its pre-mRNA, VEGF-A is produced under several isoforms characterized by the combination of their C-terminal domains, which determines their respective structure, availability and affinity for c...

journal_title：Angiogenesis

authors： Delcombel R,Janssen L,Vassy R,Gammons M,Haddad O,Richard B,Letourneur D,Bates D,Hendricks C,Waltenberger J,Starzec A,Sounni NE,Noël A,Deroanne C,Lambert C,Colige A

更新日期：2013-04-01 00:00:00

abstract：:Cancer cells have diverse mechanisms for utilizing the vasculature; they can initiate the formation of new blood vessels from preexisting ones (sprouting angiogenesis) or they can form cohesive interactions with the abluminal surface of preexisting vasculature in the absence of sprouting (co-option). The later process...

journal_title：Angiogenesis

authors： Zhang Y,Wang S,Dudley AC

更新日期：2020-02-01 00:00:00

abstract：:Therapeutic angiogenesis is a promising strategy to promote the formation of new or collateral vessels for tissue regeneration and repair. Since changes in tissue oxygen concentrations are known to stimulate numerous cell functions, these studies have focused on the oxygen microenvironment and its role on the angiogen...

journal_title：Angiogenesis

authors： Decaris ML,Lee CI,Yoder MC,Tarantal AF,Leach JK

更新日期：2009-01-01 00:00:00

abstract：:CM101, an anti-pathoangiogenic polysaccharide derived from group B streptococcus, has been shown to inhibit inflammatory angiogenesis and accelerate wound healing in a mouse model and minimize scarring/gliosis following spinal cord injury. To evaluate the in vivo effects of CM101 on cutaneous wound healing in the pig,...

journal_title：Angiogenesis

authors： Nanney LB,Wamil BD,Whitsitt J,Cardwell NL,Davidson JM,Yan HP,Hellerqvist CG

更新日期：2001-01-01 00:00:00

abstract：:Prothrombin, a protein involved in blood coagulation, is a plasma glycoprotein composed of the Gla domain, two adjacent kringle domains, and a serine protease domain. Kringles are triple-disulfide-loop folding domains, which are found in several other blood proteins. In this study, we showed that recombinant human pro...

journal_title：Angiogenesis

authors： Kim TH,Kim E,Yoon D,Kim J,Rhim TY,Kim SS

更新日期：2002-01-01 00:00:00

abstract：:Technology has caught up with retinal diseases of neovasculature. Work with anti-cancer, anti-angiogenic agents has fueled the way for ocular therapeutics. The market size for age-related macular degeneration and diabetic retinopathy is huge. Fifteen million people in the United States alone have age-related macular d...

journal_title：Angiogenesis

authors： Sherris D

更新日期：2007-01-01 00:00:00

abstract：:Pericytes are essential mural cells distinguished by their association with small caliber blood vessels and the presence of a basement membrane shared with endothelial cells. Pericyte interaction with the endothelium plays an important role in angiogenesis; however, very few tools are currently available that allow fo...

journal_title：Angiogenesis

authors： Cuervo H,Pereira B,Nadeem T,Lin M,Lee F,Kitajewski J,Lin CS

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Endoglin (ENG) forms a receptor complex with ALK1 in endothelial cells (ECs) to promote BMP9/10 signalling. Loss of function mutations in either ENG or ALK1 genes lead to the inherited vascular disorder hereditary haemorrhagic telangiectasia (HHT), characterised by arteriovenous malformations (AVMs). Howev...

journal_title：Angiogenesis

authors： Singh E,Redgrave RE,Phillips HM,Arthur HM

更新日期：2020-11-01 00:00:00

abstract：:Matrix Gla protein (MGP) is an antagonist of bone morphogenetic proteins and expressed in vascular endothelial cells. Lack of MGP causes vascular abnormalities in multiple organs in mice. The objective of this study is to define the role of MGP in early endothelial differentiation. We find that expression of endotheli...

journal_title：Angiogenesis

authors： Yao J,Guihard PJ,Blazquez-Medela AM,Guo Y,Liu T,Boström KI,Yao Y

更新日期：2016-01-01 00:00:00

abstract：:Immunostaining with endothelial and pericyte markers was used to evaluate the cellular composition of angiogenic sprouts in several types of tumors and in the developing retina. Confocal microscopy revealed that, in addition to conventional endothelial tubes heavily invested by pericytes, all tissues contained small p...

journal_title：Angiogenesis

authors： Ozerdem U,Stallcup WB

更新日期：2003-01-01 00:00:00

abstract：:Human pancreatic tumors often overexpress the angiogenesis-promoting factor Interleukin 8 (IL-8), in part due to overexpression of NF-kappaB, a frequent occurrence in pancreatic adenocarcinoma. In this study, we demonstrate that reducing c-Src kinase activity, through either pharmacologic inhibition or small interferi...

journal_title：Angiogenesis

authors： Trevino JG,Gray MJ,Nawrocki ST,Summy JM,Lesslie DP,Evans DB,Sawyer TK,Shakespeare WC,Watowich SS,Chiao PJ,McConkey DJ,Gallick GE

更新日期：2006-01-01 00:00:00

abstract：:Inhibition of angiogenesis has become a major target in experimental cancer therapies. Vascular endothelial growth factor (VEGF) and its receptors are essential for breast cancer progression and relevant targets in experimental anti-angiogenesis. VEGF, produced by carcinoma cells, acts in a paracrine fashion on endoth...

journal_title：Angiogenesis

authors： Weigand M,Hantel P,Kreienberg R,Waltenberger J

更新日期：2005-01-01 00:00:00

abstract：:Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two isoforms in vertebrates: RCAN1.1 is constitutively expressed in most tissues, whereas transcription of RCAN1.4 is induced by several stimuli that activate the calcineurin-NFAT pathway. RCAN1.4 is h...

journal_title：Angiogenesis

authors： Alghanem AF,Wilkinson EL,Emmett MS,Aljasir MA,Holmes K,Rothermel BA,Simms VA,Heath VL,Cross MJ

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:Dysregulation of the phosphatidylinositol-3-kinase (PI3K) signaling pathway is a hallmark of human cancer, occurring in a majority of tumors. Activation of this pathway is critical for transformation and also for the angiogenic switch, which is a key step for tumor progression. The objective of this study was...

journal_title：Angiogenesis

authors： Harfouche R,Basu S,Soni S,Hentschel DM,Mashelkar RA,Sengupta S

更新日期：2009-01-01 00:00:00

abstract：:Human ribonuclease inhibitor (hRI) can inhibit angiogenesis by reversibly binding angiogenin, a member of the RNaseA superfamily, and by suppressing the expression of basic fibroblast growth factor (bFGF). Angiogenesis is necessary for the growth and metastasis of tumors. To study the links between hRI, angiogenesis, ...

journal_title：Angiogenesis

authors： Wang T,Yang M,Chen J,Watkins T,Xiuyun C

更新日期：2005-01-01 00:00:00

abstract：:Inhibiting pathologic angiogenesis can halt disease progression, but such inhibition may offer only a temporary benefit, followed by tissue revascularization after treatment stoppage. This revascularization, however, occurs by largely unknown phenotypic changes in pathologic vessels. To investigate the dynamics of ves...

journal_title：Angiogenesis

authors： Mukwaya A,Mirabelli P,Lennikov A,Thangavelu M,Ntzouni M,Jensen L,Peebo B,Lagali N

更新日期：2019-11-01 00:00:00