Anaplastic Lymphoma Kinase-Negative Anaplastic Large Cell Lymphoma Manifesting as a Scalp Hematoma After an Acute Head Injury-a Case Report and Literature Review.

Abstract:

BACKGROUND:Anaplastic large cell lymphoma (ALCL) is a malignant non-Hodgkin lymphoma, typically associated with anaplastic lymphoma kinase (ALK) expression. In some cases, lack of ALK translocation correlated with a more unfavorable prognosis. CASE DESCRIPTION:We describe a case of ALK(-) ALCL that manifested as a progressive, enlarged, swollen mass on the scalp after an acute head injury in an 84-year-old man. Neither palpable lymph nodes nor any B symptoms were noted on admission. Brain computed tomography showed a hematoma in the right posterior occipital region of the scalp as the only remarkable finding. Débridement and biopsy were performed. Histologic and immunohistochemical analysis of the specimen revealed an ALK(-) ALCL of the scalp. The lymphoma was resistant to bendamustine-containing chemotherapies, ultimately leading to the patient's death within 2 months. CONCLUSIONS:This case report highlights the importance of recognizing the possibility of an ALCL manifesting as a focal inflammatory swelling mass on the scalp.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Yeung CY,Hong KT,Chiang CP,Chen YH,Ma HI,Tsai TH

doi

10.1016/j.wneu.2015.11.020

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

688.e13-688.e16

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(15)01540-5

journal_volume

88

pub_type

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