Beyond fibrosis: stellate cells as liver stem cells.

Abstract:

:The high regenerative potential of the liver is driven by parenchymal and non-parenchymal cells, which restore the original liver mass after injury by cell proliferation. The contribution of stem- and progenitor cells to liver regeneration is mainly observed when hepatocyte proliferation is impaired. However, the origin of stem/progenitor cells and their effectivity to restore injured liver is currently discussed controversially. Hepatic stellate cells, which are mainly known for their contribution to fibrosis in chronic liver diseases, were recently identified as mesenchymal stem cells (MSC) of the liver. Stellate cells are also involved in liver regeneration and fulfill a dual function by supporting neighboring cells and developing into liver epithelial cells. This demonstrates that stellate cells not only exhibit the same expression profile and differentiation potential but also functional similarities to MSC of other organs, which are at present intensively studied by many groups for their therapeutic use in liver diseases.

journal_name

Z Gastroenterol

authors

Kordes C,Sawitza I,Götze S,Schumacher E,Häussinger D

doi

10.1055/s-0035-1566895

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

1425-31

issue

12

eissn

0044-2771

issn

1439-7803

journal_volume

53

pub_type

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