Young adults HIV-1 infected by vertical transmission in southern Brazil - Clinical, demographic, and virological features.

Abstract:

:Combination antiretroviral therapy promotes longer life expectancy, making it possible for perinatally HIV-infected patients to achieve adulthood. Past therapy was not always optimized, suggesting that virological and host features may also play a role in survival. The aim of this study is to describe characteristics of HIV disease progression associated with virological features in adolescents perinatally that were HIV infected. A case series was conducted including 81 patients that were in follow-up at Hospital de Clínicas/Universidade Federal do Paraná, Curitiba, Brazil. Venous blood was collected to conduct tropism and viral subtype assays. The median age was 19 years old (interquartile range 18-21), and a majority of patients were female (54.3%). Viral subtype was obtained for 66 (82%) patients, and subtypes B and C were found in 34% and 59%, respectively. Tropism assay was conducted in 55 (67%) patients: 71% were R5 and 29% X4. Distribution of viral tropism and subtype shows a significant association of subtype C with R5 tropism. Subtype C is more prevalent in southern Brazil and also in the population infected with HIV by vertical transmission. Both R5 tropism and subtype C are associated with slower progression to AIDS. The survival of these patients may be related to virological features present in a benign pattern of disease progression.

journal_name

Int J STD AIDS

authors

Martin BM,Santos JS,Scapinello FV,Ribeiro CE,Gomes-da-Silva MM,Raboni SM

doi

10.1177/0956462417712880

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

1419-1425

issue

14

eissn

0956-4624

issn

1758-1052

journal_volume

28

pub_type

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