Adjuvant treatment or primary topical monotherapy for ocular surface squamous neoplasia: a systematic review.

Abstract:

:In this systematic review, we evaluated studies involving adjuvant and primary topical treatment for ocular surface squamous neoplasia (OSSN). The findings were: (i) adjuvant 5-fluorouracil (5-FU) reduces the risk of relapse after surgical excision with mild side effects [level Ib, grade of recommendation (GR) A]. (ii) Primary topical mitomycin (MMC) produces a high rate of complete response, low recurrence rate, and mild side effects (level Ib, GR A). (iii) Primary chemotherapy versus adjuvant chemotherapy produce similar rates of recurrence, with no significant difference (level IIb, GR B). (iv) Adjuvant 5-FU versus MMC showed no significant differences, with mild side effects in both groups and a better toxicity profile for MMC (level III, GR C). (v) Primary topical 5-FU versus MMC versus interferon (IFN) showed similar rates of tumor recurrence, mild side effects for all drugs, and more severe side effects in the 5-FU arm, followed successively by MMC and IFN (level III, GR C).

journal_name

Arq Bras Oftalmol

authors

Viani GA,Fendi LI

doi

10.5935/0004-2749.20170032

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

131-136

issue

2

eissn

0004-2749

issn

1678-2925

pii

S0004-27492017000200131

journal_volume

80

pub_type

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