Self-assembly of t-butyloxycarbonyl protected dipeptide methyl esters composed of leucine, isoleucine, and valine into highly organized structures from alcohol and aqueous alcohol mixtures.

abstract：:Combinatorial library composed of rigid rod-like peptides with a triple-helical scaffold was constructed. The component peptides were designed to have various combinations of basic and neutral (or hydrophobic) amino acid residues based on collagen-like (Gly-Pro-Yaa)-repeating sequences, inspired from the basic and amp...

journal_title：Biopolymers

authors： Masuda R,Kudo M,Dazai Y,Mima T,Koide T

更新日期：2016-11-04 00:00:00

abstract：:Oxaliplatin (OXA) was coupled to PEGylated polyamidoamine dendrimers of fourth generation (G4-PEG@OXA) in the comparison to PEGylated ones of odd generation (G3.5-PEG@OXA). Proton nuclear magnetic resonance and Fourier-transform infrared spectroscopy were used to confirm the successful incorporation of OXA as well as ...

journal_title：Biopolymers

authors： Ho MN,Bach LG,Nguyen DH,Nguyen CH,Nguyen CK,Tran NQ,Nguyen NV,Hoang Thi TT

更新日期：2019-07-01 00:00:00

abstract：:A series of iota-carrageenans containing different amounts of nu-carrageenan (0-23 monomer %) have been prepared from neutrally extracted carrageenan of Eucheuma denticulatum. nu-Carrageenan is the biochemical precursor of iota-carrageenan. The conformational order-disorder transition and rheological properties of the...

journal_title：Biopolymers

authors： van de Velde F,Rollema HS,Grinberg NV,Burova TV,Grinberg VY,Tromp RH

更新日期：2002-11-15 00:00:00

abstract：:The enzymatic activities of native myosin light chain kinases are subject to modification by interaction with Ca2(+)-calmodulin (CaM). The interaction between myosin light chain kinase isolated from turkey gizzard (tgMLCK) and calmodulin isolated from bovine testes (CaMbt) and wheat germ (CaMwg) has been examined by m...

journal_title：Biopolymers

authors： Garone L,Albaugh S,Steiner RF

更新日期：1990-01-01 00:00:00

abstract：:The comprehensive understanding of disassembly mechanism of amyloid fibrils requires nano-scale characterization of the mechanical properties of amyloid fibrils during the disassembly process. In this work, gemini surfactant C12 C6 C12 Br2 micelles were used as a probe to disassemble Aβ(1-40) fibrils. The microstructu...

journal_title：Biopolymers

authors： Wang W,Guo Z,Sun J,Li Z

更新日期：2017-02-01 00:00:00

abstract：:Studies of catalytically active DNA sequences have expanded considerably since the first artificial deoxyribozyme was identified in 1994. Nevertheless, the field is still quite young, and advances in both fundamental understanding and practical applications of deoxyribozymes are still developing. Deoxyribozymes that e...

journal_title：Biopolymers

authors： Höbartner C,Silverman SK

更新日期：2007-12-05 00:00:00

abstract：:Protein flexibility and conformational diversity is well known to be a key characteristic of the function of many proteins. Human blood coagulation proteins have multiple substrates, and various protein-protein interactions are required for the smooth functioning of the coagulation cascade to maintain blood hemostasis...

journal_title：Biopolymers

authors： Singh N,Briggs JM

更新日期：2008-12-01 00:00:00

abstract：:Flow linear dichroism measurements extended into the vacuum uv region yield inclinations for the base normal from the helix axis of 21 degrees for dA and 40 degrees for dT in the X-form of poly(dAdT).poly(dAdT). These inclination angles are similar to the B form of the synthetic polymer, but the axes around which the ...

journal_title：Biopolymers

authors： Riazance-Lawrence JH,Kang H,Chou PJ,Johnson WC Jr,Vorlícková M

更新日期：1994-11-01 00:00:00

abstract：:The quantum yield for cyclobutyl-pyrimidine dimerization in DNA has been observed to increase approximately linearly with increasing pyrimidine tract length. A model without adjustable parameters for this yield is proposed based on energy delocalization, vibronic symmetry switching, and saturation statistics that desc...

journal_title：Biopolymers

authors： Texter J

更新日期：1992-01-01 00:00:00

abstract：:Using a variety of spectroscopic techniques, a number of molecular functionalities have been studied in relation to the adsorption process of proteins to air-water interfaces. While ellipsometry and drop tensiometry are used to derive information on adsorbed amount and exerted surface pressure, external reflection cir...

journal_title：Biopolymers

authors： de Jongh HH,Kosters HA,Kudryashova E,Meinders MB,Trofimova D,Wierenga PA

更新日期：2004-05-01 00:00:00

abstract：:Proteins and nucleic acids are able to adopt their native conformation and perform their biological role only in the presence of water with which they actively interact in a mutually modifying way. Traditionally, hydrophobic effect has been considered to be the major factor stabilizing biopolymeric structures. However...

journal_title：Biopolymers

authors： Chalikian TV

更新日期：2003-12-01 00:00:00

abstract：:Many studies have examined consensus sequences required for protein-glycosaminoglycan interactions. Through the synthesis of helical heparin binding peptides, this study probes the relationship between spatial arrangement of positive charge and heparin binding affinity. Peptides with a linear distribution of positive ...

journal_title：Biopolymers

authors： Rullo A,Nitz M

更新日期：2010-03-01 00:00:00

abstract：:The HPLC retention behavior of three complete single methionine and methionine sulfoxide replacement sets of two 18-mer model peptides and neuropeptide Y (NPY) were investigated. All peptides were prepared by multiple solid-phase peptide synthesis. Plotting the retention time differences between methionine and methion...

journal_title：Biopolymers

authors： Rothemund S,Krause E,Beyermann M,Bienert M,Sykes BD,Sönnichsen FD

更新日期：1996-08-01 00:00:00

abstract：:A suite of FORTRAN programs, PREF, is described for calculating preference functions from the data base of known protein structures and for comparing smoothed profiles of sequence-dependent preferences in proteins of unknown structure. Amino acid preferences for a secondary structure are considered as functions of a s...

journal_title：Biopolymers

authors： Juretić D,Lee B,Trinajstić N,Williams RW

更新日期：1993-02-01 00:00:00

abstract：:The ion atmosphere created by monovalent (Na(+) ) or divalent (Mg(2+) ) cations surrounding a B-form DNA duplex were examined using atomistic molecular dynamics (MD) simulations and the nonlinear Poisson-Boltzmann (PB) equation. The ion distributions predicted by the two methods were compared using plots of radial and...

journal_title：Biopolymers

authors： Robbins TJ,Ziebarth JD,Wang Y

更新日期：2014-08-01 00:00:00

abstract：:We describe here a new method for determining the conformational stability of antiparallel beta-sheets. Due to coupling between the transition dipoles, beta-sheet conformations typically exhibit a characteristic high-frequency amide I component centered at approximately 1680 cm(-1). Using one beta-sheet protein and tw...

journal_title：Biopolymers

authors： Wang T,Xu Y,Du D,Gai F

更新日期：2004-10-05 00:00:00

abstract：:The solid state conformational analysis of [Tyr4] cyclolinopeptide A has been carried out by x-ray diffraction studies. The crystal structure of the monoclinic form, grown from a dioxane-water mixture [alpha = 9.849 (5) A, b = 20.752 (4) A, c = 16.728 (5) A, beta = 98.83 (3) degrees, space group P21, Z = 2], shows the...

journal_title：Biopolymers

authors： Saviano M,Rossi F,Filizola M,Isernia C,Di Blasio B,Benedetti E,Pedone C,Siemion IZ,Pedyczak A

更新日期：1995-10-01 00:00:00

abstract：:A winter flounder antifreeze polypeptide (HPLC-6) has been studied in vacuo and in aqueous solution using molecular dynamics computer simulation techniques. The helical conformation of this polypeptide was found to be stable both in vacuum and in solution. The major stabilizing interactions were found to be the main-c...

journal_title：Biopolymers

authors： McDonald SM,Brady JW,Clancy P

更新日期：1993-10-01 00:00:00

abstract：:The conformational behavior of the synthetic peptide, Boc-Gly-Val-Gly-Gly-Leu-OMe, containing the X-Gly-Gly and Gly-Gly-X (X = Val or Leu) repeating sequences and constituting a fragment of elastin was investigated by molecular mechanics and molecular dynamics (MD) simulation. The results suggest that, irrespective of...

journal_title：Biopolymers

authors： Lelj F,Tamburro AM,Villani V,Grimaldi P,Guantieri V

更新日期：1992-02-01 00:00:00

abstract：:Inhibitor design against viral targets must take into account the peculiar characteristics of viral biology-in particular, the plasticity of their replicative machinery. This includes maturational cleavage of the polyprotein, which is mediated by virally encoded proteases. Designing against a movable target is particu...

journal_title：Biopolymers

authors： Bianchi E,Pessi A

更新日期：2002-01-01 00:00:00

abstract：:A new family of small plant peptides was recently described and found to be widespread throughout the Millereae and Heliantheae tribes of the sunflower family Asteraceae. These peptides originate from the post-translational processing of unusual seed-storage albumin genes, and have been termed PawS-derived peptides (P...

journal_title：Biopolymers

authors： Franke B,Jayasena AS,Fisher MF,Swedberg JE,Taylor NL,Mylne JS,Rosengren KJ

更新日期：2016-11-01 00:00:00

abstract：:In the first two papers of this series, the tools necessary to evaluate substrate ring deformations were developed, and then the modeling of short amylose fragments (maltotriose and maltopentaose) inside the catalytic site of barley alpha-amylase was performed. In this third paper, this docking has been extended to th...

journal_title：Biopolymers

authors： André G,Buléon A,Haser R,Tran V

更新日期：1999-12-01 00:00:00

abstract：:The pulsed-field gel electrophoresis (PFG) is a newly developing technique used in the fractionation of large DNA fragments. Advances in PFG demand a better understanding in the corresponding mechanisms of DNA dynamics in the gel network. Detailed experiments are needed to verify and to extend existing theoretical pre...

journal_title：Biopolymers

authors： Chu B,Wang ZL,Xu RL,Lalande M

更新日期：1990-03-01 00:00:00

abstract：:Bovine carbonmonoxy hemoglobin investigated with light scattering studies is found to dissociate from its native tetramer structure into dimers and monomers. The values of the hydrated tetramer radius, RT = 32.1 A, and the fractional dissociation vs pH, have been obtained at different ionic strengths from the autocorr...

journal_title：Biopolymers

authors： Lunelli L,Zuliani P,Baldini G

更新日期：1994-06-01 00:00:00

abstract：:Adrenocorticotropin (ACTH) (1-10), an adrenocorticotropin hormone fragment, has been studied by molecular dynamics (MD) simulation in an NPT ensemble in an explicit dodecylphosphocholine (DPC) micelle. Two starting configurations of the peptide/micelle system, corresponding to the insertion and surface-binding modes, ...

journal_title：Biopolymers

authors： Gao X,Wong TC

更新日期：2001-06-01 00:00:00

abstract：:Second-generation dendrimers have been prepared on solid phase by successive additions of branched polyproline building blocks starting from two different branching units anchored to the solid support. The preparation of Pro-rich building blocks was carried out by stepwise solid-phase synthesis and their iterative add...

journal_title：Biopolymers

authors： Sanclimens G,Crespo L,Giralt E,Royo M,Albericio F

更新日期：2004-01-01 00:00:00

abstract：:Dermaseptins, small polycationic peptides synthesized by amphibians, exert a lytic action on bacteria, protozoa, yeast, and filamentous fungi at micromolar concentrations, but unlike polylysines, show little hemolytic activity. Dermaseptins S are active only against bacteria and form aggregates at high peptide/lipid r...

journal_title：Biopolymers

authors： Castiglione-Morelli MA,Cristinziano P,Pepe A,Temussi PA

更新日期：2005-01-01 00:00:00

abstract：:The thermal conformational transitions of two sonicated samples of schizophyllan were studied in water-dimethylsulfoxide (DMSO) mixtures by high-sensitivity differential scanning calorimetry (DSC). Two transitions were observed over most of the range of solvent compositions. These were assigned to an internal change o...

journal_title：Biopolymers

authors： Kitamura S,Kuge T

更新日期：1989-02-01 00:00:00

abstract：:The discovery of the prototype delta opioid antagonists TIPP (H-Tyr-Tic-Phe-Phe-OH) and TIP (H-Tyr-Tic-Phe-OH) in 1992 was followed by extensive structure-activity relationship studies, leading to the development of analogues that are of interest as pharmacological tools or as potential therapeutic agents. Stable TIPP...

journal_title：Biopolymers

authors： Schiller PW,Weltrowska G,Berezowska I,Nguyen TM,Wilkes BC,Lemieux C,Chung NN

更新日期：1999-01-01 00:00:00

abstract：:The self-cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal structures, the conformation of...

journal_title：Biopolymers

authors： Sefcikova J,Krasovska MV,Spacková N,Sponer J,Walter NG

更新日期：2007-04-05 00:00:00