The role of Listeria monocytogenes cell wall surface anchor protein LapB in virulence, adherence, and intracellular replication.

Abstract:

:Lmof2365_2117 is a Listeria monocytogenes putative cell wall surface anchor protein with a conserved domain found in collagen binding proteins. We constructed a deletion mutation in lmof2365_2117 in serotype 4b strain F2365, evaluated its virulence, and determined its ability to adhere and invade colonic epithelial cells and macrophages. In A/J mice, colonization of liver was significantly higher for F2365 than for F2365Δ2117. The ability of F2365Δ2117 to adhere to Caco-2 cells was significantly lower than F2365. The mutant also showed impaired ability to replicate in intestinal epithelial cell and murine macrophages relative to wild type F2365. Lmof2365_2117 contributed to L. monocytogenes attachment to catfish fillets. Because of its role in adherence to Caco-2 cells, we designated Lmof2365_2117 Listeria adhesion protein B (LapB). The carboxy terminus of LapB is similar to a domain in collagen binding proteins, but our results show that L. monocytogenes does not bind collagen.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Reddy S,Akgul A,Karsi A,Abdelhamed H,Wills RW,Lawrence ML

doi

10.1016/j.micpath.2015.12.012

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

19-25

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(15)30086-3

journal_volume

92

pub_type

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