Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury.

Abstract:

:Ischemia/reperfusion (I/R) injury remains a major complication of liver resection, transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic I/R are complex and diverse involving the interaction of cell injury in hepatocytes, immune cells, and endothelium, mitochondrial dysfunction is a cardinal event culminating in hepatic reperfusion injury. Mitochondrial autophagy, so-called mitophagy, is a key cellular process that regulates mitochondrial homeostasis and eliminates damaged mitochondria in a timely manner. Growing evidence accumulates that I/R injury is attributed to defective mitophagy. This review aims to summarize the current understanding of autophagy and its role in hepatic I/R injury and highlight the various therapeutic approaches that have been studied to ameliorate injury.

journal_name

Biomed Res Int

authors

Go KL,Lee S,Zendejas I,Behrns KE,Kim JS

doi

10.1155/2015/183469

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

183469

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

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