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Aortic involvement in relapsing polychondritis.

Abstract：

OBJECTIVE:To assess prevalence of aortic involvement in relapsing polychondritis (RP) patients; to evaluate clinical features and long-term outcome of RP patients exhibiting aortitis, aortic ectasia and/or aneurysm. METHODS:One hundred and seventy-two RP patients underwent aortic computed tomography (CT)-scan; they were seen in 3 medical centers. RESULTS:Eleven patients (6.4%) had aortic involvement, occurring within a median time of 2 years after RP diagnosis. CT-scan showed isolated aortitis (n=2); the 9 other patients exhibited: aortitis and aortic aneurysm (n=2) or ectasia (n=1), isolated aortic aneurysm (n=4) or ectasia (n=2); aortic localizations were as follows: thoracic (n=6), abdominal (n=2), thoracic and abdominal (n=4) aorta. Patients exhibited: resolution (n=3) improvement (n=3), stabilization (n=4) or deterioration (n=1) of aortic localization. Five patients experienced recurrence of aortic localization; one patient died of aortic abdominal aneurysm rupture. Predictive factors of death related to aortic complications were: aortitis on CT-scan, higher median levels of erythrocyte sedimentation rate. Predictive parameters of aortic relapses were: aortitis on CT-scan and involvement of the abdominal aorta. CONCLUSIONS:This study underlines that aortic involvement is severe in RP. Furthermore, we suggest that RP patients exhibiting poor prognostic factors, including panaortitis and higher values of ESR, may require more aggressive therapy.

journal_name

Joint Bone Spine

journal_title

Joint bone spine

authors

Le Besnerais M,Arnaud L,Boutémy J,Bienvenu B,Lévesque H,Amoura Z,Marie I

doi

10.1016/j.jbspin.2017.05.009

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

345-351

issue

3

eissn

1297-319X

issn

1778-7254

pii

S1297-319X(17)30100-8

journal_volume

85

pub_type

杂志文章,多中心研究

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