Abstract:
:The FNR protein of Escherichia coli is a regulatory protein that activates the transcription of its target genes in response to oxygen limitation. Site-directed mutagenesis was used to show that a 28-residue N-terminal segment containing three cysteines is essential for normal FNR function. The cysteine residue which is centrally located in the three-cysteine cluster (Cys-Ala-Ile-His-Cys-Gln-Asp-Cys) was also shown to be essential for FNR activity. Possible mechanisms by which this cysteine residue might function in the response of FNR to anaerobiosis are discussed.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Spiro S,Guest JRdoi
10.1111/j.1365-2958.1988.tb00080.xsubject
Has Abstractpub_date
1988-11-01 00:00:00pages
701-7issue
6eissn
0950-382Xissn
1365-2958journal_volume
2pub_type
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更新日期:2020-04-01 00:00:00
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更新日期:2008-08-01 00:00:00
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