What is special about 200 kDa hyaluronan that activates hyaluronan receptor signaling?

abstract：:Endogenous lectins can control critical biological responses, including cell communication, signaling, angiogenesis and immunity by decoding glycan-containing information on a variety of cellular receptors and the extracellular matrix. Galectin-1 (Gal-1), a prototype member of the galectin family, displays only one ca...

journal_title：Glycobiology

authors： Romero JM,Trujillo M,Estrin DA,Rabinovich GA,Di Lella S

更新日期：2016-12-01 00:00:00

abstract：:Glycoprotein oligosaccharides function as tags for protein quality control in the endoplasmic reticulum (ER). Since most of proteins are glycosylated and function only after they are properly folded, glycoprotein glycan profiles in the ER might be useful to analyze various cellular status including diseases. Here, we ...

journal_title：Glycobiology

authors： Iwamoto S,Isoyama M,Hirano M,Yamaya K,Ito Y,Matsuo I,Totani K

更新日期：2013-01-01 00:00:00

abstract：:In this work, focused on possible application of α-L-fucosidases from bacterial sources in the synthesis of α-L-fucosylated glycoconjugates, several nonpathogenic aerobic bacterial strains were screened for α-L-fucosidase activity. Among them Paenibacillus thiaminolyticus was confirmed as a potent producer of enzyme w...

journal_title：Glycobiology

authors： Benesová E,Lipovová P,Dvoráková H,Králová B

更新日期：2013-09-01 00:00:00

abstract：:In the present study, we studied anti-Alzheimer's disease (AD) activities of chondroitin sulfate (CS) oligosaccharides with different molecular weights. CS from shark cartilage was degraded by a recombinant CS endolyase, chondroitinase ABC I (CHSase ABC I), and CS disaccharide (DP2), tetrasaccharide (DP4), hexasacchar...

journal_title：Glycobiology

authors： Zhao N,Meng J,Jiang W,Xu W,Liu C,Wang F

更新日期：2020-10-09 00:00:00

abstract：:In Campylobacter jejuni, the PglB oligosaccharyltransferase catalyzes the transfer of a heptasaccharide from a lipid donor to asparagine within the D/E-X1-N-X2-S/T sequon (X1,2 ≠ P) or releases this heptasaccharide as free oligosaccharides (fOS). Using available crystal structures and sequence alignments, we identifie...

journal_title：Glycobiology

authors： Barre Y,Nothaft H,Thomas C,Liu X,Li J,Ng KKS,Szymanski CM

更新日期：2017-10-01 00:00:00

abstract：:In this report we describe a system capable of resolving all of the known unsaturated disaccharides derived from the chondroitin sulphates, dermatan sulphate and hyaluronic acid by chondroitinase digestion. This system is superior to others in that the non-sulphated and mono-, di- and tri-sulphated disaccharides can b...

journal_title：Glycobiology

authors： Zebrower M,Kieras FJ,Heaney-Kieras J

更新日期：1991-06-01 00:00:00

abstract：:At weaning, the intestinal mucosa surface glycans change from predominantly sialylated to fucosylated. Intestinal adaptation from milk to solid food is regulated by intrinsic and extrinsic factors. The contribution by glucocorticoid, an intrinsic factor, and colonization by microbiota, an extrinsic factor, was measure...

journal_title：Glycobiology

authors： Nanthakumar NN,Meng D,Newburg DS

更新日期：2013-10-01 00:00:00

abstract：:Xylosylated and core alpha1,3-fucosylated N-glycans from plants are immunogenic, and they play a still obscure role in allergy and in the field of plant-made protein pharmaceuticals. We immunized mice to generate monoclonal antibodies (mAbs) binding plant N-glycans specifically via the epitope containing either the xy...

journal_title：Glycobiology

authors： Jin C,Bencúrová M,Borth N,Ferko B,Jensen-Jarolim E,Altmann F,Hantusch B

更新日期：2006-04-01 00:00:00

abstract：:Glycation of immunoglobulin G (IgG) can result from incubation with a reducing sugar in vitro or during circulation in vivo. Upon injection of a recombinantly produced human therapeutic IgG into humans, changes in the glycation levels could be observed as a function of circulation time. Mass changes on the individual ...

journal_title：Glycobiology

authors： Goetze AM,Liu YD,Arroll T,Chu L,Flynn GC

更新日期：2012-02-01 00:00:00

abstract：:The egg jellies of sea urchins contain sulfated polysaccharides with unusual structures, composed of linear chains of l-fucose or l-galactose with well-defined repetitive units. The specific pattern of sulfation and the position of the glycosidic bond vary among sulfated polysaccharides from different species. These p...

journal_title：Glycobiology

authors： Cinelli LP,Castro MO,Santos LL,Garcia CR,Vilela-Silva AC,Mourão PA

更新日期：2007-08-01 00:00:00

abstract：:F-type lectins are fucolectins with characteristic fucose and calcium-binding sequence motifs and a unique lectin fold (the "F-type" fold). F-type lectins are phylogenetically widespread with selective distribution. Several eukaryotic F-type lectins have been biochemically and structurally characterized, and the F-typ...

journal_title：Glycobiology

authors： Bishnoi R,Khatri I,Subramanian S,Ramya TN

更新日期：2015-08-01 00:00:00

abstract：:Galectins are a sub-family of lectins, defined by their highly conserved beta-sandwich structures and ability to bind to beta-galactosides, like Gal beta1-4 Glc (lactose). Here, we used (15)N-(1)H HSQC and pulse field gradient (PFG) NMR spectroscopy to demonstrate that galectin-1 (gal-1) binds to the relatively large ...

journal_title：Glycobiology

authors： Miller MC,Klyosov A,Mayo KH

更新日期：2009-09-01 00:00:00

abstract：:We expressed recombinant Cys subdomains in COS-7 cells to examine the role of this highly conserved protein domain in mucin biosynthesis. The entire Cys1 and Cys5 and Cys1 and Cys3 subdomains in MUC5AC and MUC5B, respectively, each with six carboxyl terminal histidine residues, were pulse-labeled with [(35)S]cysteine/...

journal_title：Glycobiology

authors： Perez-Vilar J,Randell SH,Boucher RC

更新日期：2004-04-01 00:00:00

abstract：:Galbeta1-4GlcNAc is thought to be a common disaccharide unit preferentially recognized by vertebrate galectins. Eight-amino-acid residues conserved in proteins belonging to the galectin family have been suggested to be responsible for recognition. Meanwhile, we isolated and analyzed endogenous N-glycans of Caenorhabdi...

journal_title：Glycobiology

authors： Takeuchi T,Nishiyama K,Sugiura K,Takahashi M,Yamada A,Kobayashi S,Takahashi H,Natsugari H,Kasai K

更新日期：2009-12-01 00:00:00

abstract：:There is increasing evidence that secretory fluids such as tears, saliva and milk play an important role in protecting the human body from infection via a washing mechanism involving glycan-mediated adhesion of potential pathogens to secretory glycoproteins. Interaction of sweat with bacteria is well established as th...

journal_title：Glycobiology

authors： Peterson RA,Gueniche A,Adam de Beaumais S,Breton L,Dalko-Csiba M,Packer NH

更新日期：2016-03-01 00:00:00

abstract：:Different classes of glycans are implicated as mediators of apical protein sorting in the secretory pathway of epithelial cells, but recent research indicates that sorting to the apical and basolateral surfaces may occur before completion of glycan synthesis. We have previously shown that a proteoglycan (PG) core prot...

journal_title：Glycobiology

authors： Moen A,Hafte TT,Tveit H,Egge-Jacobsen W,Prydz K

更新日期：2011-11-01 00:00:00

abstract：:Sulphated N-linked carbohydrate chains isolated from recombinant human tissue plasminogen activator expressed in mouse epithelial (C127) cells were analysed as oligosaccharide alditols by methylation analysis, liquid secondary ion mass spectrometry, and one- and two-dimensional 1H-NMR spectroscopy. The results demonst...

journal_title：Glycobiology

authors： Pfeiffer G,Stirm S,Geyer R,Strube KH,Bergwerff AA,Kamerling JP,Vliegenthart JF

更新日期：1992-10-01 00:00:00

abstract：:Detailed structural and functional studies over the last decade have led to current recognition of the mycobacterial lipoarabinomannan (LAM) as a phosphatidylinositol anchored lipoglycan with diverse biological activities. Fatty acylation has been demonstrated to be essential for LAM to maintain its functional integri...

journal_title：Glycobiology

authors： Chatterjee D,Khoo KH

更新日期：1998-02-01 00:00:00

abstract：:Sequestration of Plasmodium falciparum-infected red blood cells (IRBCs) in the human placenta is mediated by chondroitin 4-sulfate (C4S). A cytoadherence assay using chondroitin sulfate proteoglycans (CSPGs) is widely used for studying C4S-IRBC interactions. Bovine tracheal chondroitin sulfate A (CSA) preparation lack...

journal_title：Glycobiology

authors： Muthusamy A,Achur RN,Valiyaveettil M,Madhunapantula SV,Kakizaki I,Bhavanandan VP,Gowda CD

更新日期：2004-07-01 00:00:00

abstract：:Phytohaemagglutinin (PHA) is the major lectin present in the seeds of the common bean, Phaseolus vulgaris, and PHA-L is the leucocyte-agglutinating form of this lectin. This tetrameric glycoprotein accumulates in the vacuoles of storage parenchyma cells. Based on amino acid sequence comparisons of legume lectins and t...

journal_title：Glycobiology

authors： Mirkov TE,Chrispeels MJ

更新日期：1993-12-01 00:00:00

abstract：:Glycosaminoglycan (GAG) assembly initiates through the formation of a linkage tetrasaccharide region serving as a primer for both chondroitin sulfate (CS) and heparan sulfate (HS) chain polymerization. A possible role for sulfation of the linkage structure and of the constitutive disaccharide unit of CS chains in the ...

journal_title：Glycobiology

authors： Gulberti S,Jacquinet JC,Chabel M,Ramalanjaona N,Magdalou J,Netter P,Coughtrie MW,Ouzzine M,Fournel-Gigleux S

更新日期：2012-04-01 00:00:00

abstract：:Shigella flexneri is a gram-negative bacterium responsible for serious enteric infections that occur mainly in the terminal ileum and colon. High interest in Shigella, as a human pathogen, is driven by its antibiotic resistance and the necessity to develop a vaccine against its infections. Vaccines of the last generat...

journal_title：Glycobiology

authors： Molinaro A,Silipo A,Castro CD,Sturiale L,Nigro G,Garozzo D,Bernardini ML,Lanzetta R,Parrilli M

更新日期：2008-03-01 00:00:00

abstract：:Mouse macrophage galactose/N-acetylgalactosamine-specific C-type lectin (MMGL) is a type II transmembrane glycoprotein belonging to the C-type lectin family. Our development of monoclonal antibodies led us to discover that a calcium-dependent conformational change is detected by an antibody (termed mAb LOM-11) and tha...

journal_title：Glycobiology

authors： Hosoi T,Imai Y,Irimura T

更新日期：1998-08-01 00:00:00

abstract：:Apicomplexan protozoa are a phylum of parasites that includes pathogens such as Plasmodium, the causative agent of the most severe form of malaria responsible for almost 1 million deaths per year and Toxoplasma gondii causing toxoplasmosis, a disease leading to cerebral meningitis in immunocompromised individuals or t...

journal_title：Glycobiology

authors： Debierre-Grockiego F,Schwarz RT

更新日期：2010-07-01 00:00:00

abstract：:The trehalose-P synthase was purified to near homogeneity from the cytoplasmic fraction of Mycobacterium smegmatis. At the final stage of purification, the enzyme preparation showed one major band of 59 kDa on SDS gels. The 59 kDa band became labeled with N3-UDP[32P]-glucose, and this labeling was inhibited in a conce...

journal_title：Glycobiology

authors： Pan YT,Drake RR,Elbein AD

更新日期：1996-06-01 00:00:00

abstract：:Ceramide is a pivotal molecule in signal transduction and an essential structural component of the epidermal permeability barrier. The epidermis is marked by a high concentration of ceramide and by a unique spectrum of ceramide species: Besides the two ceramide structures commonly found in mammalian tissue, N-acylsphi...

journal_title：Glycobiology

authors： Vielhaber G,Brade L,Lindner B,Pfeiffer S,Wepf R,Hintze U,Wittern KP,Brade H

更新日期：2001-06-01 00:00:00

abstract：:Endolysins are bacteriophage enzymes that lyse their bacterial host for phage progeny release. They commonly contain an N-terminal catalytic domain that hydrolyzes bacterial peptidoglycan (PG) and a C-terminal cell wall-binding domain (CBD) that confers enzyme localization to the PG substrate. Two endolysins, phage ly...

journal_title：Glycobiology

authors： Ganguly J,Low LY,Kamal N,Saile E,Forsberg LS,Gutierrez-Sanchez G,Hoffmaster AR,Liddington R,Quinn CP,Carlson RW,Kannenberg EL

更新日期：2013-07-01 00:00:00

abstract：:Protozoan parasites of the genus Leishmania have a glycoconjugate surface coat (the glycocalyx) that acts as the interface between the parasite and its external environment. The principal components of the glycocalyx, the lipophosphoglycans and the glycoinositolphospholipids, have a variety of functions that facilitat...

journal_title：Glycobiology

authors： Smith DF,Rangarajan D

更新日期：1995-03-01 00:00:00

abstract：:The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate-carbohydrate interactions, CCI...

journal_title：Glycobiology

authors： Sletmoen M,Gerken TA,Stokke BT,Burchell J,Brewer CF

更新日期：2018-07-01 00:00:00

abstract：:All IgG-type antibodies are N-glycosylated in their Fc part at Asn-297. Typically, a fucose residue is attached to the first N-acetylglucosamine of these complex-type N-glycans. Antibodies lacking core fucosylation show a significantly enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) and an increased effi...

journal_title：Glycobiology

authors： von Horsten HH,Ogorek C,Blanchard V,Demmler C,Giese C,Winkler K,Kaup M,Berger M,Jordan I,Sandig V

更新日期：2010-12-01 00:00:00