Six-Minute Walk Test as a Measure of Walking Capacity in Ambulatory Individuals With Amyotrophic Lateral Sclerosis.

Abstract:

OBJECTIVE:To determine the validity of the 6-minute walk test (6MWT) as an outcome measure to evaluate walking capacity in ambulatory patients with amyotrophic lateral sclerosis (ALS). DESIGN:Observational study. SETTING:Multidisciplinary ALS clinic at an academic medical center. PARTICIPANTS:Patients with ALS (N=186) who ambulate without (stage I) or with (stage II) an assistive device. INTERVENTIONS:Not applicable. MAIN OUTCOME MEASURE:Walking distance obtained from the 6MWT. RESULTS:Participants performed the 6MWT, 25-foot walk test (25FWT), Timed Up and Go (TUG) test, lower extremity maximum voluntary isometric contraction (MVIC), ALS Functional Rating Scale-Revised (ALSFRS-R), and forced vital capacity (FVC). Walking capacity was reduced to 66% predicted of healthy subjects (75.2%±22% in stage I; 42.6%±22% in stage II). The 6MWT correlated with all other outcome measures in ambulatory patients with ALS (25FWT: r=-.74, P≤.0001; TUG test: r=-.80, P≤.0001; MVIC: r=.64, P≤.0001; percent predicted FVC: r=.25, P≤.0007; ALSFRS-R: r=.52, P≤.0001; ALSFRS-R gross motor subscore: r=.71, P≤.0001). When ambulatory patients with ALS were stratified by stage of ambulation, the 6MWT was associated with all other outcome measures in stage I (25FWT: r=-.56, P≤.0001; TUG test: r=-.66, P≤.0001; MVIC: r=.51, P≤.0001; percent predicted FVC: r=.40, P≤.02; ALSFRS-R: r=.52, P≤.0001; ALSFRS-R gross motor subscore: r=.61, P≤.0001). In stage II, the 6MWT correlated with the 25FWT (r=-.83, P≤.0001), TUG test (r=-.77, P≤.0001), MVIC (r=.47, P≤.0001), and ALSFRS gross motor subscore (r=.61, P≤.0001), but not with percent predicted FVC (r=.09, P≤.513) or ALSFRS-R (r=.21, P≤.141). CONCLUSIONS:The 6MWT is a valid measure of walking capacity of ambulatory patients with ALS that is associated with measures of lower extremity muscle strength and function in both stages of ambulation. The discordance between the 6MWT with the ALSFRS-R and percent predicted FVC in stage II ambulatory patients with ALS indicates that the 6MWT is an independent measure of ambulatory function in both stages of ambulation. The 6MWT may provide a quantitative, simple, and inexpensive outcome measure of walking capacity for early stage clinical trials in ambulatory patients with ALS.

journal_name

Arch Phys Med Rehabil

authors

Sanjak M,Langford V,Holsten S,Rozario N,Patterson CGM,Bravver E,Bockenek WL,Brooks BR

doi

10.1016/j.apmr.2017.04.004

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

2301-2307

issue

11

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(17)30266-6

journal_volume

98

pub_type

杂志文章
  • Incomplete bladder emptying in patients with stroke: is detrusor external sphincter dyssynergia a potential cause?

    abstract:OBJECTIVES:To delineate the frequency, clinical risk factors, and urodynamic mechanisms of incomplete bladder emptying (IBE) among patients with recent stroke. DESIGN:Retrospective study. SETTING:Inpatient setting in the rehabilitation ward of a university hospital. PARTICIPANTS:All patients with acute stroke admitt...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2010.03.017

    authors: Meng NH,Lo SF,Chou LW,Yang PY,Chang CH,Chou EC

    更新日期:2010-07-01 00:00:00

  • Inpatient cancer rehabilitation: a retrospective comparison of transfer back to acute care between patients with neoplasm and other rehabilitation patients.

    abstract:OBJECTIVE:To determine whether patients with diagnoses of neoplasm undergoing acute rehabilitation differ from other patients in frequency of acute care transfer and type of medical complications. DESIGN:Retrospective cohort analysis. SETTING:Acute rehabilitation hospital located within an academic medical center. P...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2008.01.014

    authors: Alam E,Wilson RD,Vargo MM

    更新日期:2008-07-01 00:00:00

  • Etiology and incidence of rehospitalization after traumatic spinal cord injury: a multicenter analysis.

    abstract:OBJECTIVES:To examine the frequency and reasons for rehospitalization in persons with acute traumatic spinal cord injury (SCI) during follow-up years and to examine the association between rehospitalization and demographics, neurologic category, payer sources, length of stay (LOS), discharge motor FIM instrument score,...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2004.03.016

    authors: Cardenas DD,Hoffman JM,Kirshblum S,McKinley W

    更新日期:2004-11-01 00:00:00

  • Chronic pain: its treatment in geriatric and younger patients.

    abstract::The response of geriatric patients to a multidisciplinary chronic pain rehabilitation program was measured by comparing outcome data on 17 older patients (55 to 78 years) to data on 20 younger patients (29 to 48 years) treated in the same program. Pretreatment data were obtained at an initial evaluation, and posttreat...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:

    authors: Middaugh SJ,Levin RB,Kee WG,Barchiesi FD,Roberts JM

    更新日期:1988-12-01 00:00:00

  • Treatment of pressure ulcers by serial casting in patients with severe spasticity of cerebral origin.

    abstract:OBJECTIVE:To assess the effectiveness of serial casting in the treatment of pressure ulcers caused by severe spasticity. DESIGN:Case series. SETTING:A clinic for the rehabilitation of persons with neurologic disorders. PATIENTS:Nine patients with 11 pressure ulcers resulting from severe cerebral spasticity, the ulce...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1053/apmr.2002.27474

    authors: Pohl M,Rückriem S,Strik H,Hörtinger B,Meissner D,Mehrholz J,Pause M

    更新日期:2002-01-01 00:00:00

  • Effects of functional knee bracing on muscle-firing patterns about the chronic anterior cruciate ligament-deficient knee.

    abstract:OBJECTIVE:To examine the effects of functional knee bracing on the muscle-firing patterns about the chronic anterior cruciate ligament (ACL)-deficient knee in successful brace users. DESIGN:Cross-sectional comparative clinical trial. SETTING:Motion analysis laboratory. PARTICIPANTS:Ten active individuals with unilat...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1053/s0003-9993(03)00280-6

    authors: Smith J,Malanga GA,Yu B,An KN

    更新日期:2003-11-01 00:00:00

  • Are tender points associated with cervical radiculopathy?

    abstract:OBJECTIVE:To determine if there is an association between cervical radiculopathy and tender spots in the neck and upper extremity on the side of radiculopathy. DESIGN:Prospective cross-sectional study. SETTING:Outpatient spine clinic within an academic institution. PARTICIPANTS:Convenience sample of 16 subjects with...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2004.11.023

    authors: Letchuman R,Gay RE,Shelerud RA,VanOstrand LA

    更新日期:2005-07-01 00:00:00

  • Instrumental straight-leg raising: results in patients.

    abstract::Straight-leg raising is used as a diagnostic test for both elastogenic (passive muscle stretch test) and nonelastogenic (Lasègue's test) pathology in patients unable to bend forward from the standing position while holding the knees in extension. The test assessment is based on the range of the leg excursion and the t...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 临床试验,杂志文章

    doi:10.1016/0003-9993(94)90174-0

    authors: Göeken LN,Hof AL

    更新日期:1994-04-01 00:00:00

  • Graded exercise testing of mentally retarded adults: a study of feasibility.

    abstract::There is a striking absence of data on the cardiovascular fitness of mentally retarded adults and what limited data are reported reflect field or submaximal laboratory tests. This study sought to develop a protocol that would allow maximal aerobic testing (VO2max) of mentally retarded adults in the laboratory. Of 21 s...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:

    authors: Fernhall B,Tymeson G

    更新日期:1987-06-01 00:00:00

  • Ground reaction forces during ambulation in parkinsonism: pilot study.

    abstract::Gait abnormality in parkinsonism is unique and easily recognizable. A pilot study was designed at our Human Gait Laboratory to learn how this gait abnormality is reflected in ground reaction forces of patients with parkinsonism. The system permitted the collection of kinematic and force data from a subject in real tim...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:

    authors: Koozekanani SH,Balmaseda MT Jr,Fatehi MT,Lowney ED

    更新日期:1987-01-01 00:00:00

  • Failure to complete a functional restoration program for chronic musculoskeletal disorders: a prospective 1-year outcome study.

    abstract:OBJECTIVE:To compare comprehensively the likelihood of various socioeconomically relevant outcomes between functional restoration completers and noncompleters, while simultaneously identifying risk factors for noncompletion. DESIGN:A prospective cohort study of patients with chronic disabling occupational musculoskele...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2005.02.010

    authors: Proctor TJ,Mayer TG,Theodore B,Gatchel RJ

    更新日期:2005-08-01 00:00:00

  • Poor agreement on health-related quality of life between children with congenital hand differences and their parents.

    abstract:OBJECTIVES:To determine agreement between children with congenital hand differences (CHDs) and their parents on health-related quality of life (HRQOL) and to explore whether characteristic variables were associated with this agreement on different domains of HRQOL. DESIGN:Survey. SETTING:University hospital, outpatie...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2011.11.023

    authors: Ardon MS,Selles RW,Roebroeck ME,Hovius SE,Stam HJ,Janssen WG

    更新日期:2012-04-01 00:00:00

  • Clenbuterol in the prevention of muscle atrophy: a study of hindlimb-unweighted rats.

    abstract:OBJECTIVE:To determine whether the administration of clenbuterol, a beta2-adrenergic agonist, prevents loss of muscle mass during a period of imposed inactivity. DESIGN:Randomized trial. SETTING:Basic laboratory research. ANIMALS:Thirty Fischer 344 Brown Norway F1 Hybrid rats, 12 and 30 months of age. INTERVENTIONS...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1053/apmr.2001.23756

    authors: Herrera NM Jr,Zimmerman AN,Dykstra DD,Thompson LV

    更新日期:2001-07-01 00:00:00

  • Rehabilitation of orthopedic and rheumatologic disorders. 1. Osteoporosis assessment, treatment, and rehabilitation.

    abstract:UNLABELLED:This self-directed learning module highlights a clinical vignette of a female patient with osteoporosis and addresses the clinical presentation, assessment, medical management, and rehabilitation approaches to a patient with an acute vertebral fracture. It is part of the study guide on osteoporosis in the Se...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2004.12.009

    authors: Kaplan RJ,Vo AN,Stitik TP,Kamen LB,Bitar AA,Shih VC

    更新日期:2005-03-01 00:00:00

  • High-voltage galvanic stimulation on wound healing in guinea pigs: longer-term effects.

    abstract::The purpose of this investigation was to determine the effects of high-voltage stimulation (HVS) on wound tensile strength properties and wound closure (histology). Eighteen mature guinea pigs with full-thickness incisions were treated with HVS for 45 minutes daily for 2 weeks; 9 animals were studied after the 14 days...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/s0003-9993(95)80122-7

    authors: Brown M,Gogia PP,Sinacore DR,Menton DN

    更新日期:1995-12-01 00:00:00

  • The premotor potential.

    abstract::A small waveform precedes the compound muscle action potential evoked from the thenar eminence with median nerve stimulation with high amplifier gains. This potential is believed to emanate from fibers destined to innervate the volar aspect of the first digit. It has been suggested recently that the source of the prem...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:

    authors: Dumitru D,Walsh NE,Ramamurthy S

    更新日期:1989-07-01 00:00:00

  • Preinjury predictors of life satisfaction at 1 year after traumatic brain injury.

    abstract:OBJECTIVE:To investigate the predictive value of preinjury factors for satisfaction with life (SWL) at 1-year posttraumatic brain injury (TBI). DESIGN:Secondary analysis of prospective, longitudinal registry using data collected during inpatient rehabilitation and at 1-year post-TBI. SETTING:Fifteen specialized brain...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2012.02.036

    authors: Davis LC,Sherer M,Sander AM,Bogner JA,Corrigan JD,Dijkers MP,Hanks RA,Bergquist TF,Seel RT

    更新日期:2012-08-01 00:00:00

  • Wheelchair cushion modification and its effect on pressure.

    abstract::Prevention of pressure sores is a major objective in the rehabilitation of individuals with paraplegia and quadriplegia. Wheelchair cushions made of polyurethane foam are frequently prescribed to relieve pressure and reduce the risk of ulceration for persons seated in wheelchairs. Because no cushion uniformly distribu...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:

    authors: Garber SL,Krouskop TA

    更新日期:1984-10-01 00:00:00

  • A 2-item screen for depression in rehabilitation inpatients.

    abstract:OBJECTIVE:To generate a brief screening measure to assist frontline rehabilitation health care workers to rapidly and validly screen patients for depressive symptoms. DESIGN:Case series. SETTING:Inpatient rehabilitation unit. PARTICIPANTS:Five hundred patients (age, >/=60y) cognitively able to complete the outcome m...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2004.04.042

    authors: Cully JA,Graham DP,Kramer JR

    更新日期:2005-03-01 00:00:00

  • Priorities for Closing the Evidence-Practice Gaps in Poststroke Aphasia Rehabilitation: A Scoping Review.

    abstract:OBJECTIVE:To identify implementation priorities for poststroke aphasia management relevant to the Australian health care context. DATA SOURCES:Using systematized searches of databases (CINAHL and MEDLINE), guideline and stroke websites, and other sources, evidence was identified and extracted for 7 implementation crit...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2017.08.474

    authors: Shrubsole K,Worrall L,Power E,O'Connor DA

    更新日期:2018-07-01 00:00:00

  • Acquired limb deficiencies. 1. Acquired limb deficiencies in children and young adults.

    abstract:UNLABELLED:This self-directed learning module highlights prosthetic treatment considerations and challenges in children and young adults. It is part of the chapter on acquired limb deficiencies in the Self-Directed Physiatric Education Program for practitioners and trainees in physical medicine and rehabilitation. This...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章,评审

    doi:

    authors: Bryant PR,Pandian G

    更新日期:2001-03-01 00:00:00

  • Qualitative Development of a Discrete Choice Experiment for Physical Activity Interventions to Improve Knee Osteoarthritis.

    abstract:OBJECTIVE:To describe the qualitative process used to develop attributes and attribute levels for inclusion in a discrete choice experiments (DCE) for older adult physical activity interventions. DESIGN:Five focus groups (n=41) were conducted, grounded in the Health Action Process Approach framework. Discussion emphas...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2016.11.024

    authors: Pinto D,Danilovich MK,Hansen P,Finn DJ,Chang RW,Holl JL,Heinemann AW,Bockenholt U

    更新日期:2017-06-01 00:00:00

  • Use of Sinemet in locked-in syndrome: a report of two cases.

    abstract::Locked-in syndrome describes a neurological condition usually associated with infarction of the ventral pons. Such patients are diagnosed with quadriplegia, lower cranial nerve paralysis, and mutism. The patient is alert but communication is severely limited and usually is accomplished by blinking or using vertical ey...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/s0003-9993(95)80554-0

    authors: Ockey RR,Mowry D,Varghese G

    更新日期:1995-09-01 00:00:00

  • Using gabapentin to treat failed back surgery syndrome caused by epidural fibrosis: A report of 2 cases.

    abstract::Failed back surgery syndrome (FBSS) is a long-lasting, often disabling, and relatively frequent (5%-10%) complication of lumbosacral spine surgery. Epidural fibrosis is among the most common causes of FBSS, and it is often recalcitrant to treatment. Repeated surgery for fibrosis has only a 30% to 35% success rate, whe...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1053/apmr.2001.21867

    authors: Braverman DL,Slipman CW,Lenrow DA

    更新日期:2001-05-01 00:00:00

  • Absence of consistent effects of repetitive transcutaneous electrical stimulation on soleus H-reflex in normal subjects.

    abstract::Our purpose was to determine the effects of transcutaneous electrical nerve stimulation (TENS) on the soleus H-reflex amplitude in normal subjects. Eleven subjects were tested in five experimental sessions, the purpose of which was to compare the effects of 30 minutes of TENS delivered at either 50 or 99Hz (250 micros...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0003-9993(94)90090-6

    authors: Goulet C,Arsenault AB,Levin MF,Bourbonnais D,Lepage Y

    更新日期:1994-10-01 00:00:00

  • Amitriptyline in severely depressed spinal cord-injured patients: rapidity of response.

    abstract::Nine severely depressed spinal cord-injured patients, six quadriplegic and three paraplegis, required psychiatric consultations and were treated with amitriptyline, with particular attention to the speed of response. The degree of depression was rated by using an Emergency Depression Rating Scale for Plegic Patients d...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:

    authors: Kim SP,Davis SW,Sell GH

    更新日期:1977-04-01 00:00:00

  • Reliability of the assessment of lumbar range of motion and maximal isometric strength.

    abstract:OBJECTIVE:To examine the interobserver reliability and intrasubject variability of the assessment of lumbar range of motion (ROM) and maximal isometric strength in asymptomatic subjects by using commercially available equipment. DESIGN:A cross-sectional repeated-measures design. SETTING:Ambulatory care in a universit...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2006.01.007

    authors: Roussel N,Nijs J,Truijen S,Breugelmans S,Claes I,Stassijns G

    更新日期:2006-04-01 00:00:00

  • Moderate-heeled shoes and knee joint torques relevant to the development and progression of knee osteoarthritis.

    abstract:OBJECTIVE:To determine if women's dress shoes with heels of just 1.5 in (3.8 cm) in height increases knee joint torques, which are thought to be relevant to the development and/or progression of knee osteoarthritis (OA) in both the medial and patellofemoral compartments. DESIGN:Randomized controlled trial. SETTING:A ...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.apmr.2004.09.018

    authors: Kerrigan DC,Johansson JL,Bryant MG,Boxer JA,Della Croce U,Riley PO

    更新日期:2005-05-01 00:00:00

  • Effects of single-task versus dual-task training on balance performance in older adults: a double-blind, randomized controlled trial.

    abstract:OBJECTIVE:To compare the effect of 3 different approaches to balance training on dual-task balance performance in older adults with balance impairment. DESIGN:A double-blind, randomized controlled trial. SETTING:University research laboratory. PARTICIPANTS:Older adults (N=23) with balance impairment (mean age, 74.8y...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.apmr.2008.09.559

    authors: Silsupadol P,Shumway-Cook A,Lugade V,van Donkelaar P,Chou LS,Mayr U,Woollacott MH

    更新日期:2009-03-01 00:00:00

  • Plasma homocysteine level and functional outcome of patients with ischemic stroke.

    abstract:OBJECTIVE:To investigate the possible relationships between total plasma homocysteine level (tHcy) and functional outcome of stroke patients as evaluated by the FIM instrument. DESIGN:Retrospective chart analysis. SETTING:Inpatient stroke rehabilitation ward of a university-affiliated referral hospital. PARTICIPANTS...

    journal_title:Archives of physical medicine and rehabilitation

    pub_type: 杂志文章

    doi:10.1016/j.apmr.2004.01.031

    authors: Mizrahi EH,Fleissig Y,Arad M,Adunsky A

    更新日期:2005-01-01 00:00:00