Abstract:
:Dengue is a major global public health problem affecting Latin America and Mexico Prevention and control measures, focusing on epidemiological surveillance and vector control, have been partially effective and costly, thus, the development of a vaccine against dengue has created great expectations among health authorities and scientific communities worldwide. The CYD-TDV dengue vaccine produced by Sanofi-Pasteur is the only dengue vaccine evaluated in phase 3 controlled clinical trials. Notwithstanding the significant contribution to the development of a vaccine against dengue, the three phase 3 clinical studies of CYD-TDV and the meta-analysis of the long-term follow up of those studies, have provided evidence that this vaccine exhibited partial vaccine efficacy to protect against virologically confirmed dengue and lead to four considerations: a) adequate vaccine efficacy against dengue virus (DENV) infections 3 and 4, less vaccine efficacy against DENV 1 and no protection against infection by DENV 2; b) decreased vaccine efficacy in dengue seronegative individuals at the beginning of the vaccination; c) 83% and 90% protection against hospitalizations and severe forms of dengue, respectively, at 25 months follow-up; and d) increased hospitalization for dengue in the vaccinated group, in children under nine years of age at the time of vaccination, detected since the third year of follow-up. The benefit of the CYD-TDV vaccine can be summarized in the protection against infection by DENV 3 and 4, as well as protection for hospitalizations and severe cases in people over nine years, who have had previous dengue infection, working mainly as a booster. In this review we identified elements on efficacy and safety of this vaccine that must be taken into account in the licensing process and potential inclusion in the national vaccination program of Mexico. The available scientific evidence on the CYD-TDV vaccine shows merits, but also leads to relevant questions that should be answered to properly assess the safety profile of the product and the target populations of potential benefit. In this regard we consider it would be informative to complete the 6-year follow-up after starting vaccination, according to the company's own study protocol recommended by the World Health Organization. As with any new vaccine, the potential licensing and implementation of the CYD-TDV as part of Mexico's vaccination program, requires a clear definition of the balance between the expected benefits and risks. Particularly with a vaccine with variable efficacy and some signs of risk, in the probable case of licensing, the post-licensed period must involve the development of detailed protocols to immediately identify risks or any health event associated with vaccination.
journal_name
Salud Publica Mexjournal_title
Salud publica de Mexicoauthors
Hernández-Ávila M,Lazcano-Ponce E,Hernández-Ávila JE,Alpuche-Aranda CM,Rodríguez-López MH,García-García L,Madrid-Marina V,López Gatell-Ramírez H,Lanz-Mendoza H,Martínez-Barnetche J,Díaz-Ortega JL,Ángeles-Llerenas A,Barrientos-Gutsubject
Has Abstractpub_date
2016-01-01 00:00:00pages
71-83issue
1eissn
0036-3634issn
1606-7916pii
S0036-36342016000100014journal_volume
58pub_type
杂志文章,评审abstract:OBJECTIVE:To determine the willingness to pay of parents of teenage daughters for a vaccine against human papillomavirus in the Maule Region, Chile. MATERIALS AND METHODS:A sample of 386 parents with daughters between 12 and 18 years old, representing the five largest cities of the Region of Maule, socioeconomically s...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To contribute to the knowledge on the impact of human productive activities on the environment, human health, and the survival of animal species. MATERIAL AND METHODS:A study case of water bodies in the south of Sonora was conducted in 1996. The software Decision Support System for Industrial Pollution Contr...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To determine the number of micronuclei and nuclear anomalies in Mexico's indigenous population. MATERIALS AND METHODS:One hundred twenty indigenous individuals were evaluated, including thirty from the ethnicities Cora, Huichol, Tarahumara and Tepehuano. The number of micronuclei (MN) and any nuclear abnorma...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:10.21149/8318
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:To evaluate equity in access by comparing geographic, economic, and organizational barriers as well as authorization obstacles that women encounter depending on their affiliation with the social security health system. MATERIAL AND METHODS:A retrospective survey was conducted among women undergoing breast c...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:10.1590/s0036-36342009000800015
更新日期:2009-01-01 00:00:00
abstract::Four experiences in health education in communities located in the state of Lara in Venezuela were analyzed from a sociopsychological perspective. Under a qualitative approach, the information was obtained from three sources: documentary analysis of didactic material; participant observation in workshops, and intervie...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::Quantitative ultrasound (QUS) appears to be developing into an acceptable, low-cost and readily-accessible alternative to dual X-ray absorptiometry (DXA) measurements of bone mineral density (BMD) in the detection and management of osteoporosis. Perhaps the major difficulty with their widespread use is that many diffe...
journal_title:Salud publica de Mexico
pub_type: 杂志文章,评审
doi:10.1590/s0036-36342009000700006
更新日期:2009-01-01 00:00:00
abstract::The conceptual and methodological basis of the National Health Survey II (NHS-II) are described and recent advances in multidisciplinary public health research in Mexico, both conceptual and methodological, are synthesized. The design of the NHS-II concentrated on the study of the access, quality of care and health at...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Intoxication produced by Karwinskia humboldtiana presents a neurological picture similar to that of poliomyelitis, Guillain-Barré syndrome or other polyradiculoneuritis with which it is frequently confused. The purpose of this paper is to report the frequency of this intoxication, by means of the antecedent of ingesti...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Chagas disease in the state of Jalisco, Mexico was described for the first time in 1967; however, knowledge on the disease remains in a slow process. Between 1967 and 2006, the disease was described in its acute and chronic forms. The vector species have been identified, and the parasite Trypanosoma cruzi has been iso...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:10.1590/s0036-36342008000600012
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:Pyrodinium bahamense monitoring in water and their toxins in rock oyster Striostrea prismatica in Santiago Astata and Puerto Escondido Oaxaca was performed from September 2009 to July 2010. MATERIALS AND METHODS:Pyrodinium bahamense abundance in water, and concentration and toxic profile of paralytic shellfi...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To determine the relative risk (RR) of non-fatal unintentional and violence-related injury associated with alcohol consumption in three emergency departments in Latin America (2001-2002). MATERIAL AND METHODS:Pair-matched case-crossover was used to obtain RR estimates for alcohol in non-fatal injuries among ...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:10.1590/s0036-36342008000700003
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To compare the clinical and epidemiological characteristics of cholera patients and patients with diarrhea of different etiology (controls), treated at Mexican Institute of Social Security medical units in northeast Mexico City, from 1995 to 1998. MATERIAL AND METHODS:Cross-sectional analytical study design....
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract::The objective of this article is to review the decentralization process that took place in the 1980s. First, some principles in relation to this topic are presented. Next, the legal foundations and the agreements which were established for Federation-states coordination are outlined, as well as basic points related to...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:Understand what Mexican key stakeholders think about the judicialization of the right to health in Mexico. MATERIALS AND METHODS:30 semi-structured interviews were conducted at different settings in Mexico City with representatives of the judiciary, legislative power, Health Sector (HS), pharmaceutical indus...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:10.21149/10491
更新日期:2020-09-23 00:00:00
abstract::This article is the first of two parts of a research report on the evolution and magnitude of poverty in Mexico. Herein are presented the methodologies used in both parts and the evolution of poverty. The Poverty Line methodology (PL), in its Standard Basket of Essential Satisfiers version, is succinctly explained. Tw...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::This article analyzes 33 risk indicators about problematic drugs use, based in epidemiological studies in representative student samples, carried out in Mexico since 1975. The indicators are distributed among the variation sources proposed by the classic epidemiological model (environment-agent-host), and are aimed to...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::The National Seroepidemiologic survey was carried out by the General Directorate of Epidemiology of the Ministry of Health from March 1987 to May 1988. One of the objectives of this survey was to know the mean cholesterol levels in the whole country and in each of the different states of the Mexican Republic by sex an...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVE:To introduce the Hospital Standardized Mortality Ratio (HSMR) as an alternative to assess the quality of hospital care in Mexico. MATERIAL AND METHODS:Data-sets of public hospital discharges were used as source of information. The analyses were based in a logistic model to estimate the risk of hospital death...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:To describe knowledge,attitudes and practices in oral health of parents and caregivers. MATERIAL AND METHODS:A total of 333 parents and eight caregivers in children's homes in Colombia in 2010 completed questionnaires and participated in focus group interviews.The data was analyzed for frequency using the χ...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:10.1590/s0036-36342011000300009
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To offer current evidence about age at sexual initiation and contraceptive use among adolescent and adult women of different age groups, places of residence, and marital status in Mexico. MATERIALS AND METHODS:Data were analyzed from ENSANUT 2006 and 2012 surveys on knowledge and use of contraceptives. RESU...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To assess the effects of maternal overweight and obesity as risk factors for overweight and obesity in Mexican school-age children (5 to 11 years old) who participated in the National Nutrition Survey 1999 (NNS-99). MATERIAL AND METHODS:Information obtained by the NNS-99 was used to evaluate the relationship...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:10.1590/s0036-36342005000600009
更新日期:2005-11-01 00:00:00
abstract::Escherichia coli colonizes the human intestinal tract within hours of birth and is considered a non-pathogenic member of the normal intestinal flora. However, there are six pathogenic groups that may produce diarrhea: enterotoxigenic (ETEC), enterohemorrhagic (EHEC), enteroinvasive (EIEC), enteropathogenic (EPEC), ent...
journal_title:Salud publica de Mexico
pub_type: 杂志文章,评审
doi:
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVES:To assess the economic impact of a 100% smoke-free law on bars and restaurants in an Argentinean province. MATERIALS AND METHODS:We conducted a time series analysis of restaurant and bar revenues in the province of Santa Fe 31 months before and 29 months after the implementation of the 100% smoke-free envir...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:10.1590/s0036-36342012000300004
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To analyze the current knowledge of pathogen-insect interactions amenable for the design of molecular-based control strategies of vector-borne diseases. MATERIALS AND METHODS:We examined malaria, dengue, and Chagas disease pathogens and insect molecules that participate in interactions during their vectors i...
journal_title:Salud publica de Mexico
pub_type: 杂志文章,评审
doi:10.21149/8140
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To assess the risk for alcohol abuse among individuals with a positive family history of alcohol abuse (FH+). MATERIAL AND METHODS:The study population was a sample (n = 8,890) drawn from a 1988 national survey on addictions in Mexico City's urban population. Data analysis consisted of frequency and associat...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To describe the external causes of death and mortality trends due to injuries and poisoning in Mexican adolescents, from 1979 to 1997. MATERIAL AND METHODS:This is a descriptive study of deaths occurring in Mexico from 1979 to 1997. Data were abstracted, coded, and entered in electronic format, by Instituto ...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::The Global Smokefree Partnership has recently prepared a map of smokefree campaigns and policies around the world. It focuses primarily on countries that are parties to the WHO Framework Convention on Tobacco Control, but other countries were included. The smokefree status of 172 countries was mapped. Of these countri...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:10.1590/s0036-36342008000900006
更新日期:2008-01-01 00:00:00
abstract::The activities concerning mental health care of psychiatric disorders during more than 50 years of service (1966-2016) at the Children's Psychiatric Hospital "Dr. Juan N. Navarro" (HPI), as well as the progressive development of teaching and research, have contributed to its positioning as a leading institution in med...
journal_title:Salud publica de Mexico
pub_type: 历史文章,杂志文章
doi:10.21149/8514
更新日期:2017-07-01 00:00:00
abstract::Non-communicable diseases are at the center of international consultation and there's a general agreement on saying that several issues need to be solved before implementing prevention strategies and intervention programs. A sound knowledge of all the factors involved in the epidemic spread of a disease is the first t...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:10.21149/spm.v56s2.5182
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To establish the frequency of compliance to pharmacological therapy, and to identify non-compliance factors, in relation to metabolic control on patients with type-II diabetes mellitus. MATERIAL AND METHODS:A comparative cross-sectional study was conducted between 1997 and 1998, among 150 type-II diabetic pa...
journal_title:Salud publica de Mexico
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00