Abstract:
OBJECTIVE:The objective of this research was to identify and replicate the participation of KLK4 gene polymorphisms in the susceptibility to dental decay. METHODS:A total of 200 patients were recruited using ICDAS criteria - 100 of them with dental caries and 100 with no history of the disease. Buccal cells were collected and the DNA was extracted and amplified using PCR. RESULTS:During the descriptive analysis, the variables ethnicity, biofilm, and gingivitis and the markers rs2242670 and rs2978642 were statistically significant. In the multivariate analysis, the marker rs2242670 and the variable biofilm maintained statistical significance. CONCLUSION:Genetic variations in the KLK4 gene may contribute to dental decay.
journal_name
Caries Resjournal_title
Caries researchauthors
Cavallari T,Tetu Moyses S,Moyses SJ,Iani Werneck Rdoi
10.1159/000464450subject
Has Abstractpub_date
2017-01-01 00:00:00pages
240-243issue
3eissn
0008-6568issn
1421-976Xpii
000464450journal_volume
51pub_type
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