Tryptophan-induced pathogenesis of breast cancer.

Abstract:

BACKGROUND:The pathogenesis of breast cancer remains unclear. AIMS:To investigate the pathogenesis of breast cancer through targeted metabolomics of amino acids components in serum of patients with breast cancer. METHODS:Patients with breast cancers were enrolled in our hospital between year January 1(st), 2013 and December 31(st), 2014. Targeted analysis of amino acids was performed using ESI-QTOF-MS instrument. In vitro experiment was performed to determine the influence of tryptophan towards interleukin-10 (IL-10) secretion by CD4+ T cell. RESULTS:Targeted metabolomics of amino acids showed that the level of tryptophan significantly (p<0.05) increased in patients with breast cancer. Furthermore, the biological function of tryptophan was determined through determining the influence of tryptophan towards IL-10 secretion using in vitro method. The addition of tryptophan (100 uM) in the cell medium can significantly inhibited the secretion of IL-10 by CD4+ T cells, as indicated by the mRNA level and protein concentration. CONCLUSION:The inhibition of IL-10 secretion by CD4+ T cells is a potential pathogenesis of breast cancer.

journal_name

Afr Health Sci

journal_title

African health sciences

authors

Cao ZG,Qin XB,Liu FF,Zhou LL

doi

10.4314/ahs.v15i3.36

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

982-5

issue

3

eissn

1680-6905

issn

1729-0503

pii

jAFHS.v15.i3.pg982

journal_volume

15

pub_type

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