Abstract:
BACKGROUND:The pathogenesis of breast cancer remains unclear. AIMS:To investigate the pathogenesis of breast cancer through targeted metabolomics of amino acids components in serum of patients with breast cancer. METHODS:Patients with breast cancers were enrolled in our hospital between year January 1(st), 2013 and December 31(st), 2014. Targeted analysis of amino acids was performed using ESI-QTOF-MS instrument. In vitro experiment was performed to determine the influence of tryptophan towards interleukin-10 (IL-10) secretion by CD4+ T cell. RESULTS:Targeted metabolomics of amino acids showed that the level of tryptophan significantly (p<0.05) increased in patients with breast cancer. Furthermore, the biological function of tryptophan was determined through determining the influence of tryptophan towards IL-10 secretion using in vitro method. The addition of tryptophan (100 uM) in the cell medium can significantly inhibited the secretion of IL-10 by CD4+ T cells, as indicated by the mRNA level and protein concentration. CONCLUSION:The inhibition of IL-10 secretion by CD4+ T cells is a potential pathogenesis of breast cancer.
journal_name
Afr Health Scijournal_title
African health sciencesauthors
Cao ZG,Qin XB,Liu FF,Zhou LLdoi
10.4314/ahs.v15i3.36subject
Has Abstractpub_date
2015-09-01 00:00:00pages
982-5issue
3eissn
1680-6905issn
1729-0503pii
jAFHS.v15.i3.pg982journal_volume
15pub_type
杂志文章abstract:Background:Hospital-acquired infections (HAIs), one of the leading causes of, morbidity and mortality, are common in developing countries. Methicillin-resistant staphylococcus aureus (MRSA), commonest cause of HAIs, has been isolated from the hands of more than half of health care workers. Practice of hand hygiene may ...
journal_title:African health sciences
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journal_title:African health sciences
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journal_title:African health sciences
pub_type: 杂志文章,随机对照试验
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journal_title:African health sciences
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pub_type: 杂志文章,评审
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journal_title:African health sciences
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journal_title:African health sciences
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journal_title:African health sciences
pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
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