Abstract:
:Glaucoma is one of the leading causes of visual impairment worldwide. Classically, clinicians have evaluated patients through a full ophthalmological examination including gonioscopy, measurement of intraocular pressure (IOP), and assessment of the optic nerve. New imaging modalities have further enhanced our ability to evaluate glaucoma; however, our treatments have not evolved as much. Whether one uses medical treatment with topical ocular antihypertensives, laser trabeculoplasty, or filtering surgery, the mainstay of treatment is to lower IOP. However, as our understanding of the disease evolves, mechanisms other than elevated IOP have been implicated in glaucoma pathogenesis. Recent animal model studies have shown a possible role of the immune system in the pathophysiology of glaucoma. This article explores the current understanding of immune reactions in glaucoma, which could lead to a new paradigm of treatment for human disease.
journal_name
Semin Ophthalmoljournal_title
Seminars in ophthalmologyauthors
Kamat SS,Gregory MS,Pasquale LRdoi
10.3109/08820538.2015.1114858subject
Has Abstractpub_date
2016-01-01 00:00:00pages
147-54issue
1-2eissn
0882-0538issn
1744-5205journal_volume
31pub_type
杂志文章,评审abstract:PURPOSE:We aimed to measure peripapillary retinal nerve fiber layer (RNFL) thickness in children with thalassemia major (tha-major), children with iron deficiency anemia (IDA), and children in a healthy control group. MATERIALS AND METHODS:A total of 47 children with tha-major and 22 children with IDA were selected fr...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2013.839811
更新日期:2014-01-01 00:00:00
abstract::Secondary causes of ocular surface disease are-to a large extent-due to disorders of the ocular adnexae. The main pathomechanisms involved include exposure, abrasion and malnutrition, resulting from a multitude of disorders such as ec- or entropion (e.g. in cicatrizing conjunctivitis), lid retraction and severe aqueou...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820530590931377
更新日期:2005-04-01 00:00:00
abstract::The management of a patient with a suspected posterior communicating artery aneurysm is discussed with emphasis on neuroimaging including magnetic resonance angiography (MRA), computed tomography angiography (CTA) and intra-arterial digital subtraction angiography (DSA). This paper underscores the advantages and disad...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820530801978534
更新日期:2008-05-01 00:00:00
abstract::Purpose: To compare the success rates and safety of transscleral cyclophotocoagulation (TSCPC) for the treatment of refractory glaucoma using the slow coagulation technique and the conventional technique. Methods: A retrospective, interventional case series of 44 patients (44 eyes) who underwent TSCPC using the slow c...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2019.1638946
更新日期:2019-01-01 00:00:00
abstract::Purpose: To evaluate detailed corneal parameters of inflammatory bowel disease (IBD) patients, including Crohn's disease (CD) and ulcerative colitis (UC) patients, and to assess associations between anterior segment values and other clinical variables.Methods: This prospective cross-sectional case-control study at a t...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2019.1684525
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Investigate risk factors for unplanned return to the operating room after resident-performed cataract surgery. DESIGN:Retrospective case-control study. SETTING:Institutional. METHODS:Study population: All patients with reoperation within 90 days of resident-performed phacoemulsification were matched to fou...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2016.1208760
更新日期:2018-01-01 00:00:00
abstract::Acute acquired comitant esotropia (AACE) is characterized by a sudden-onset eye misalignment with an equal angle of deviation in all fields of gaze. This form of esotropia is distinct from common forms of childhood esotropia, such as infantile esotropia and accommodative esotropia, in the rapid tempo and typically lat...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820538.2016.1228398
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To estimate the prevalence and risk factors for polypoidal choroidal vasculopathy (PCV) in a general Japanese population. METHODS:This population-based, cross-sectional study was conducted in 2007 with subjects from the Hisayama Study. Of the 3,648 residents in Hisayama, Japan, 2,663 who were ≥ 50 years old we...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1080/08820538.2018.1506483
更新日期:2018-01-01 00:00:00
abstract::Laser photocoagulation of the entire area of the neovascular lesion is the only proven treatment for subfoveal choroidal neovascularization secondary to age-related macular degeneration with a poor natural history. However, there are some limiting factors such as patient eligibility, a significant decline in visual ac...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539809066080
更新日期:1998-03-01 00:00:00
abstract::Conventional suprathreshold retinal photocoagulation is a destructive procedure, but chorioretinal damage can be decreased by changing laser parameters and clinical endpoints. Laser effects can be localized by decreasing laser wavelength, spot size, and exposure duration, as well as by adopting threshold or subthresho...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539909069538
更新日期:1999-12-01 00:00:00
abstract:PURPOSE:To present a case of unilateral development of severe corneal vascularization in the eye of a keratoconic patient implanted with Intacs microthin prescription inserts and concurrent bilateral use of rigid gas permeable (RGP) contact lenses. METHODS:A 20-year-old male underwent unilateral implantation of Intacs...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2011.588646
更新日期:2012-01-01 00:00:00
abstract::We describe a report of a child with a horner's syndrome and sixth nerve paresis secondary to a petrous internal carotid artery (ICA) aneurysm. Management of this condition involved coiling of the aneurysm and the use of botulinum toxin to manage his strabismus and associated symptoms. ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2010.541321
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To identify the patterns of ocular injury and to determine ocular morbidity resulting from the use of firecrackers. METHODS:A prospective observational study of all patients presenting with ocular trauma consequent to fireworks usage in a tertiary eye care center in South India over a one-month period around t...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2014.962157
更新日期:2016-01-01 00:00:00
abstract::Corneal neovascularization causes deterioration of visual acuity and increases surface irregularities. Various techniques have been employed to help control the progression of corneal neovascularization; bevacizumab is a medication that targets the specific pathway of corneal neovascularization. The Boston Ocular Surf...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820530902802013
更新日期:2009-05-01 00:00:00
abstract::Vogt-Koyanagi-Harada syndrome is a bilateral, chronic, diffuse granulomatous panuveitis associated with poliosis, vitiligo, and central nervous system and auditory signs. Increasing reports have been published to describe the clinical features of Vogt-Koyanagi-Harada syndrome. These manifestations are variable. This a...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2011.588654
更新日期:2011-07-01 00:00:00
abstract::The current management of acute post-operative endophthalmitis relies on microbial confirmation, intravitreal antibiotics, and vitrectomy. The endophthalmitis vitrectomy study (EVS) demonstrated that systemic antibiotics are not necessary in post-cataract/secondary intraocular lens (IOL) acute bacterial endophthalmiti...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1076/soph.18.3.109.29804
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:To report a case of fungal corneal ulcer and bacterial orbital cellulitis as complications of bacterial endophthalmitis following cataract surgery. METHODS:A 51-year-old man underwent anterior chamber irrigation and aspiration in the left eye one day after cataract surgery because of bacterial endophthalmitis....
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2012.760613
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:To describe a case of hypertension and retinitis pigmentosa presenting with a unilateral macular star. METHODS:Case report. RESULTS:A 17-year-old female with chronic kidney disease and hypertension presented with a mild blurring of vision in the left eye. There was a history of night blindness. Both eyes had ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2015.1132331
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:We hypothesized that the ongoing neurotrophic effects of electroconvulsive therapy (ECT) might be detected in the retinal nerve fiber layer (RNFL) using optical coherence tomography (OCT). METHODS:This study was conducted using a prospective design. The RNFL thickness alterations of 18 psychiatric patients ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2018.1538419
更新日期:2018-01-01 00:00:00
abstract::Many ocular diseases, such as retinitis pigmentosa and age-related macular degeneration, reflect damage to specific cells that are not normally repaired or replaced. Preliminary results of animal studies suggest that these degenerative diseases may be treatable by transplantation of healthy fetal cells. However, obtai...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820530590921846
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To evaluate the safety, efficacy, and outcomes of early bicanalicular silicone intubation in the treatment of acute purulent dacryocystitis. METHODS:This prospective interventional case series focused on acute purulent dacryocystitis from February 2010 to March 2014. Of the 21 cases, 16 cases were treated at t...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2016.1139737
更新日期:2017-01-01 00:00:00
abstract::Ophthalmology, like any other clinical science, is constantly evolving. As our knowledge in this field expands, we enumerate and describe classical triads of symptoms or signs with relevance to ophthalmology in this article. Characteristic clinical triads for certain systemic conditions with ocular implications are al...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2015.1045150
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To evaluate the characteristics of macular edema (ME) before and after radial optic neurotomy (RON) detected by optical coherence tomography (OCT), in patients with central retinal vein occlusion (CRVO). DESIGN:Interventional case series. METHODS:Five eyes of 5 patients affected by CRVO underwent RON. Complet...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820530490519961
更新日期:2004-03-01 00:00:00
abstract::This review summarizes the advantages of Small-incision lenticule extraction (SMILE), including improved patient intraoperative experience, improved postoperative ocular surface, low incidence of regression, low re-treatment rates, and advantageous biomechanical corneal stability. Visual and refractive outcomes are si...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2020.1807028
更新日期:2020-05-18 00:00:00
abstract:PURPOSE:To report anterior segment features in unclassified anterior segment dysgenesis with overlapping features of Axenfeld-Rieger syndrome and other developmental anomalies. METHODS:This retrospective study included those with atypical or overlapping features in one or both eyes, which were identified as unclassifi...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.1080/08820538.2016.1208767
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To employ optical coherence tomography (OCT) to examine the relationship of changes in the retinal nerve fiber layer (RNFL) and macular thickness as well as ganglion cell (GC) parameters with the stage of keratoconus (KC), and to compare these changes with a control group. METHODS:A total of 84 eyes of 68 pati...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2016.1169302
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To evaluate vision-related quality of life in patients with chronic central serous chorioretinopathy (CSCR). DESIGN:Prospective, cross-sectional study. METHODS:The interviewer-administered National Eye Institute visual function questionnaire (NEI-VFQ-25) was used in 30 adult consecutive patients with chronic ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.3109/08820538.2013.839818
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION:The purpose of this paper is to perform a systematic review of the published literature on complications of intra-arterial chemothrapy (IAC) for the treatment of retinoblastoma. MATERIALS AND METHODS:A literature search was performed using the Pubmed database using the terms. Complications were divided in...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820538.2014.959188
更新日期:2014-09-01 00:00:00
abstract::Several new aqueous inflow inhibitors have been introduced over the past few years. These new agents include two alpha agonists, two topical carbonic anhydrase inhibitors, and a novel combination agent. All of these agent compare favorably with timolol in terms of aqueous suppression, though each has its own relative ...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章,评审
doi:10.3109/08820539909061469
更新日期:1999-09-01 00:00:00
abstract::Purpose: To investigate the clinical characteristics of perifoveal exudative vascular anomalous complex (PEVAC) in Korean patients. Methods: This retrospective study included 8 eyes (8 patients) diagnosed with PEVAC. Demographic characteristics of the patients, fundus photography, optical coherence tomography (OCT), f...
journal_title:Seminars in ophthalmology
pub_type: 杂志文章
doi:10.1080/08820538.2019.1626450
更新日期:2019-01-01 00:00:00